Controlled and directed local delivery of anti-inflammatory compositions
First Claim
1. A method for reducing pain, the method comprising administering to a target site in a subject in need of treatment an effective amount of a pharmaceutical composition comprising one or more biological response modifiers, wherein the one or more biological response modifiers are administered by controlled administration system.
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Abstract
The invention provides a method for alleviating pain associated with neuromuscular or skeletal injury or inflammation by controlled and directed delivery of one or more biological response modifiers to inhibit the inflammatory response which ultimately causes acute or chronic pain. Controlled and directed delivery can be provided by implantable or infusion pumps, implantable controlled release devices, or by sustained release compositions comprising biological response modifiers.
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Citations
57 Claims
- 1. A method for reducing pain, the method comprising administering to a target site in a subject in need of treatment an effective amount of a pharmaceutical composition comprising one or more biological response modifiers, wherein the one or more biological response modifiers are administered by controlled administration system.
- 22. An implant comprising a pharmaceutical composition comprising one or more biopolymers and at least one biological response modifier.
- 29. A method for treating osteolysis comprising administering to an osteolytic site in a subject in need of treatment an effective amount of a pharmaceutical composition comprising one or more biological response modifiers, wherein administration of the pharmaceutical composition is localized and sustained.
- 32. A method for alleviating pain associated with bone tumors, the method comprising administering to a tumor site in a subject in need of treatment an effective amount of a composition comprising one or more biological response modifiers, wherein administration of the composition is localized and sustained.
- 35. A system for providing pain relief medication in a mammalian subject, the system comprising controlled administration system for providing controlled and directed delivery of at least one biological response modifier to a target site in a subject in need thereof comprising an effective amount of a composition comprising at least one biological response modifier which decreases inflammation at the target site.
- 50. The use of a composition comprising one or more biological response modifiers which decrease inflammation at a target site for the manufacture of a pharmaceutical for reducing pain, wherein administration of an effective amount of the composition to a target site in a subject in need of treatment is localized and controlled.
- 51. The use of a composition comprising one or more biological response modifiers for the manufacture of a pharmaceutical for reducing pain, wherein administration of the composition to a target site in a subject in need of treatment is localized and controlled.
- 52. The use of a composition comprising one or more biological response modifiers which decrease inflammation at a target site for the manufacture of a controlled administration system for alleviating pain and limiting bone loss associated with osteolysis, wherein administration of the composition to an osteolytic site in a subject in need of treatment is localized and controlled.
- 53. The use of a composition comprising one or more biological response modifiers which decrease inflammation at a target site for the manufacture of a pharmaceutical for alleviating pain associated with bone tumors, wherein administration of the composition to a tumor site in a subject in need of treatment is localized and controlled.
Specification