Insulin bolus recommendation system

• US 20060047192A1
• Filed: 08/26/2004
• Published: 03/02/2006
• Est. Priority Date: 08/26/2004
• Status: Active Grant

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Inventors: Weinert, Stefan, Hellwig, Robert
• Granted Patent: US 7,291,107 B2
• Time in Patent Office: Days
• US Class Current: 600/365
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 20/17 delivered via infusion or injection

Abstract

A system for recommending insulin bolus quantities to an insulin user includes a display unit and memory unit coupled to a control circuit with a user blood glucose target stored in the memory unit. The control circuit is programmed to receive the user'"'"'s current blood glucose value, to determine and display via the display unit a recommended correction insulin bolus quantity if the current blood glucose value exceeds the blood glucose target, to compute a difference value as the current blood glucose value less the blood glucose target, and to produce a modified blood glucose target as a sum of the blood glucose target and the difference value for a lock-out time period if the difference value is positive. Additional correction insulin bolus quantities may be recommended during the lock-out time period if the user'"'"'s current blood glucose value exceeds the modified blood glucose target.

Claims

1. A method for recommending insulin bolus quantities to an insulin user, the method comprising the steps of:

establishing a blood glucose target for the user,

receiving a current blood glucose value of the user,

determining a recommended insulin bolus quantity if the current blood glucose value exceeds the blood glucose target,

computing a difference value as the current blood glucose value less the blood glucose target, and

increasing the blood glucose target by the difference value for a lock-out time period if the difference value is positive.

2. The method of claim 1 further including the step of repeating the receiving, determining, computing and increasing steps.

3. The method of claim 1 wherein the determining step includes computing the recommended insulin bolus quantity as a ratio of the blood glucose increase value and an insulin sensitivity value.

4. The method of claim 1 further including the step of producing a high blood glucose warning if the current blood glucose value is greater than a high blood glucose warning value.

5. The method of claim 1 further including the step of producing low blood glucose warning if the current blood glucose value is less than a low blood glucose warning value.

6. The method of claim 1 further including the step of producing a low blood glucose alert warning if the current blood glucose value is less than a low blood glucose alert value.

7. A method for recommending insulin bolus quantities to an insulin user, the method comprising the steps of:

establishing an initial blood glucose target for the user,

receiving a current blood glucose value of the user at a first time instant,

determining a first recommended insulin bolus quantity if the current blood glucose value taken at the first time instant exceeds the initial blood glucose target,

computing a first difference value as a the current blood glucose value of the user at the first time instant less the initial blood glucose target,

computing a first modified blood glucose target as a sum of the initial blood glucose target and the first difference value if the first difference value is positive,

receiving a current blood glucose value from the user at a second time instant after the first time instant and after the first recommended insulin bolus quantity is administered to the user but before expiration of a first lock-out time period since the first time instant, and

determining a second recommended insulin bolus quantity for the user if the current blood glucose value at the second time instant exceeds the first modified blood glucose target.

8. The method of claim 7 further including the steps of:

computing a second difference value as the current blood glucose value of the user at the second time instant less the first modified blood glucose target, and

computing a second modified blood glucose target as a sum of the first modified blood glucose target and the second difference value if the second difference value is positive.

9. The method of claim 8 further including the steps of:

receiving a current blood glucose value from the user at a third time instant after the second time instant and after the second recommended insulin bolus quantity is administered to the user but before expiration of the first lock-out time period since the first time instant and before expiration of a second lock-out time period since the second time instant, and

determining a third recommended insulin bolus quantity for the user if the current blood glucose value at the third time instant exceeds the second modified blood glucose target.

10. The method of claim 9 further including the steps of:

computing a third difference value as the current blood glucose value of the user at the third time instant less the second modified blood glucose target, and

computing a third modified blood glucose target as a sum of the second modified blood glucose target and the third difference value if the third difference value is positive.

11. The method of claim 8 further including the steps of:

receiving a current blood glucose value from the user at a third time instant after the second time instant, after the second recommended insulin bolus quantity is administered to the user and after expiration of the first lock-out time period since the first time instant, but before expiration of a second lock-out time period since the second time instant,

computing a third modified blood glucose target as the second modified blood glucose target less the first difference value, and

determining a third recommended insulin bolus quantity for the user if the current blood glucose value at the third time instant exceeds the third modified blood glucose target.

12. The method of claim 11 further including the steps of:

computing a third difference value as the current blood glucose value at the third time instant less the third modified blood glucose target, and

computing a fourth modified blood glucose target as a sum of the third modified blood glucose target and the third difference value if the third difference value is positive.

13. The method of claim 7 further including the step of producing a high blood glucose warning if the current blood glucose value received at either of the first and second time instants is greater than a high blood glucose warning value.

14. The method of claim 7 further including the step of producing low blood glucose warning if the current blood glucose value received at either of the first and second time instants is less than a low blood glucose warning value.

15. The method of claim 7 further including the step of producing a low blood glucose alert warning if the current blood glucose value received at either of the first and second time instants is less than a low blood glucose alert value.

17. The system of claim 10 wherein the control circuit is configured to repeatedly receive a current blood glucose value of the user from information provided by the user via the data input device, determine a recommended insulin bolus quantity if the current blood glucose value exceeds the blood glucose target, compute a difference value as the current blood glucose value less the blood glucose target, increase the blood glucose target by the difference value for a lock-out time period if the difference value is positive, and control the display to display the recommended insulin bolus quantity to the user.

16. A system for recommending insulin bolus quantities to an insulin user, the system comprising:

a data input device for providing information from the user,

a display for displaying information to the user, and

a control circuit including a memory having a blood glucose target for the user stored therein, the control circuit receiving a current blood glucose value of the user from information provided by the user via the data input device, the control circuit determining a recommended insulin bolus quantity if the current blood glucose value exceeds the blood glucose target, computing a difference value as the current blood glucose value less the blood glucose target, and increasing the blood glucose target by the difference value for a lock-out time period if the difference value is positive, the control circuit controlling the display to display the recommended insulin bolus quantity to the user.

18. The system of claim 16 wherein the control circuit is configured to control the display to display a high blood glucose warning if the current blood glucose value is greater than a high blood glucose warning value.

19. The system of claim 16 wherein the control circuit is configured to control the display to display a low blood glucose warning if the current blood glucose value is less than a low blood glucose warning value.

20. The system of claim 16 wherein the control circuit is configured to control the display to display a low blood glucose alert if the current blood glucose value is less than a low blood glucose alert value.

21. A method for recommending insulin bolus quantities to an insulin user, the method comprising the steps of:

establishing a blood glucose target for the user,

receiving a carbohydrate value indicative of a quantity of carbohydrates that will be subsequently ingested by the user,

determining a recommended compensation insulin bolus quantity as a function of the carbohydrate value, and

increasing the blood glucose target by a post-prandial increase value to produce a first modified blood glucose target for a post-prandial lock-out time period if the carbohydrate value exceeds a threshold value.

22. The method of claim 21 further including the steps of:

receiving a first current blood glucose value of the user after administering the recommended compensation insulin bolus to the user but before expiration of the post-prandial lock-out time period,

determining a first recommended correction insulin bolus quantity if the first current blood glucose value exceeds the first modified blood glucose target,

computing a first difference value as the first current blood glucose value less the first modified blood glucose target, and

increasing the modified blood glucose target by the first difference value to produce a second modified blood glucose target for a first correction lock-out time period if the first difference value is positive.

23. The method of claim 22 further including the steps of:

receiving a second current blood glucose value of the user after administering the recommended compensation insulin bolus to the user, after administering the first recommended correction insulin bolus to the user, and after expiration of the post-prandial lock-out time period, but before expiration of the first correction lock-out time period,

reducing the second modified blood glucose target by the post-prandial increase value to produce a third modified blood glucose target,

determining a second recommended correction insulin bolus quantity if the second current blood glucose value exceeds the third,

computing a second difference value as the second current blood glucose value less the third modified blood glucose target, and

increasing the third modified blood glucose target by the second difference value to produce a fourth modified blood glucose target for a second correction lock-out time period if the second difference value is positive.

24. The method of claim 23 further including the step of producing a high blood glucose warning if any of the first, second and third current blood glucose values are greater than a high blood glucose warning value.

25. The method of claim 23 further including the step of producing low blood glucose warning if any of the first, second and third current blood glucose values are less than a low blood glucose warning value.

26. The method of claim 23 further including the step of producing a low blood glucose alert warning if any of the first, second and third blood glucose values are less than a low blood glucose alert value.

27. A system for recommending insulin bolus quantities to an insulin user, the system comprising:

a data input device for providing information from the user,

a display for displaying information to the user, and

a control circuit including a memory having a blood glucose target for the user stored therein, the control circuit receiving a carbohydrate value from information provided by the user via the data input device, the carbohydrate value indicative of a quantity of carbohydrates that will be subsequently ingested by the user, the control circuit determining a recommended compensation insulin bolus quantity as a function of the carbohydrate value and increasing the blood glucose target by a post-prandial increase value to produce a first modified blood glucose target for a post-prandial lock-out time period if the carbohydrate value exceeds a threshold value, the control circuit controlling the display to display the recommended compensation insulin bolus quantity to the user.

28. The system of claim 27 wherein the control circuit receives a current blood glucose value of the user from information provided by the user via the data input device after the recommended compensation insulin bolus quantity is administered to the user, the control circuit determining a recommended correction insulin bolus quantity if the current blood glucose value exceeds the first modified blood glucose target, computing a difference value as the current blood glucose value less the first modified blood glucose target, and increasing the first modified blood glucose target by the difference value to produce a second modified blood glucose target for a correction lock-out time period if the difference value is positive, the control circuit controlling the display to display the recommended correction insulin bolus quantity to the user.

29. The system of claim 28 wherein the control circuit is configured to control the display to display a high blood glucose warning if the current blood glucose value is greater than a high blood glucose warning value.

30. The system of claim 28 wherein the control circuit is configured to control the display to display a low blood glucose warning if the current blood glucose value is less than a low blood glucose warning value.

31. The system of claim 28 wherein the control circuit is configured to control the display to display a low blood glucose alert if the current blood glucose value is less than a low blood glucose alert value.

32. A method for recommending insulin bolus quantities to an insulin user, the method comprising the steps of:

establishing a blood glucose target for the user,

receiving a first current blood glucose value of the user and a carbohydrate value indicative of a quantity of carbohydrates that will be subsequently ingested by the user,

determining a recommended compensation insulin bolus quantity as a function of the carbohydrate value,

determining a first recommended correction insulin bolus quantity if the first current blood glucose value exceeds the blood glucose target,

increasing the blood glucose target by a post-prandial increase value for a post-prandial lock-out time period if the carbohydrate value exceeds a threshold value, and

increasing the blood glucose target by a first difference value computed as the first current blood glucose value less the blood glucose target for a first correction lock-out time period if the first difference value is positive,

wherein the blood glucose target increased by either of the post-prandial increase value and the first difference value corresponds to a first modified blood glucose target.

33. The method of claim 32 further including the steps of:

receiving a second current blood glucose value of the user after administering the recommended compensation insulin bolus quantity and the recommended first correction insulin bolus quantity to the user, but before expiration of the post-prandial lock-out time period and before expiration of the first correction lock-out time period,

determining a second recommended correction insulin bolus quantity if the second current blood glucose value exceeds the blood glucose target, and

computing a second difference value as the second current blood glucose value less the first modified blood glucose target, and

increasing the first modified blood glucose target by the second difference value to produce a second modified blood glucose target for a second correction lock-out time period if the second difference value is positive.

34. The method of claim 32 further including the steps of:

receiving a second current blood glucose value of the user after administering the recommended compensation insulin bolus quantity and the recommended first correction insulin bolus quantity to the user, and after expiration of the post-prandial lock-out time period, but before expiration of the first correction lock-out time period,

decreasing the first modified blood glucose target by the post-prandial increase value to produce a second modified blood glucose target,

determining a second recommended correction insulin bolus quantity if the second current blood glucose value exceeds the second modified blood glucose target, and

computing a second difference value as the second current blood glucose value less the second modified blood glucose target, and

increasing the second modified blood glucose target by the second difference value to produce a third modified blood glucose target for a second correction lock-out time period if the second difference value is positive.

35. The method of claim 34 further including the step of producing a high blood glucose warning if either of the first and second current blood glucose values are greater than a high blood glucose warning value.

36. The method of claim 34 further including the step of producing low blood glucose warning if either of the first and second current blood glucose values are less than a low blood glucose warning value.

37. The method of claim 34 further including the step of producing a low blood glucose alert warning if any of the first and second blood glucose values are less than a low blood glucose alert value.

38. A system for recommending insulin bolus quantities to an insulin user, the system comprising:

a data input device for providing information from the user,

a display for displaying information to the user, and

a control circuit including a memory having a blood glucose target for the user stored therein, the control circuit receiving a current user blood glucose value and a carbohydrate value from information provided by the user via the data input device, the carbohydrate value indicative of a quantity of carbohydrates that will be subsequently ingested by establishing a blood glucose target for the user, the control circuit determining a recommended compensation insulin bolus quantity as a function of the carbohydrate value, and determining a recommended correction insulin bolus quantity if the current blood glucose value exceeds the blood glucose target, the control circuit increasing the blood glucose target by a post-prandial increase value for a post-prandial lock-out time period if the carbohydrate value exceeds a threshold value and increasing the blood glucose target by a difference value, corresponding to the current blood glucose value less the blood glucose target, for a correction lock-out time period if the difference value is positive, the control circuit controlling the display to display the recommended compensation and correction insulin bolus quantities to the user.

39. The system of claim 38 wherein the control circuit is configured to control the display to display a high blood glucose warning if the current blood glucose value is greater than a high blood glucose warning value.

40. The system of claim 38 wherein the control circuit is configured to control the display to display a low blood glucose warning if the current blood glucose value is less than a low blood glucose warning value.

41. The system of claim 38 wherein the control circuit is configured to control the display to display a low blood glucose alert if the current blood glucose value is less than a low blood glucose alert value.