Method and device for the delivery of a substance including a covering

• US 20060047242A1
• Filed: 08/25/2004
• Published: 03/02/2006
• Est. Priority Date: 08/25/2004
• Status: Active Grant

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Alarcon, Jason B., Mikszta, John A., Laurent, Phillipe
• Granted Patent: US 7,316,665 B2
• Time in Patent Office: Days
• US Class Current: 604/46
• CPC Class Codes: A61B 17/205 Vaccinating by means of needles or other puncturing devices
• CPC Class Codes: A61K 9/7023 Transdermal patches and similar drug-containing composite devices, e.g. cataplasms galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

An abrasion device and method for delivery of substances into the skin using a microabrader for delivering a substance into the skin are disclosed. An abrasion device with a cover is also disclosed. Such devices and methods can be effectively used to deliver bioactive substances into skin.

Claims

1. A method for delivering a substance into skin comprising the steps of:

applying a skin template onto the skin which corresponds to a predetermined abrasion area,

moving an abrader across said skin to produce an abraded area within the bounds of said predetermined abrasion area, wherein said abrader comprises an abrading surface, and;

applying said substance to the abraded area.

2. The method of claim 1 further comprising covering said abrasion area with a cover after said abrader is moved across said skin.

3. The method of claim 1 wherein said abrading surface comprises frustoconical or frustopyramidal microprotrusions that comprise at least one scraping edge projecting from said abrading surface.

4. The method of claim 1 wherein said substance is applied prior to abrasion.

5. The method of claim 1 wherein said substance is applied during abrasion.

6. The method of claim 1 wherein said substance is applied following abrasion.

7. The method of claim 1 wherein said microprotrusions are at least partially coated with said substance to be delivered.

8. The method of claim 1 wherein said skin template further comprises an opening.

9. The method of claim 2 wherein said cover is coated with a drug.

10. The method of claim 2 wherein said cover is coated with a vaccine.

11. A system for delivering a substance into skin comprising:

a skin template, which is applied to the skin, which corresponds to a predetermined abrasion area,

an abrader across said skin to produce an abraded area within the bounds of said predetermined abrasion area, wherein said abrader comprises an abrading surface.

12. The system of claim 11 further comprising a cover wherein said cover contacts at least a portion of said abrasion area.

13. The system of claim 11 wherein said abrading surface comprises frustoconical or frustopyramidal microprotrusions that comprise at least one scraping edge projecting from said abrading surface.

14. The system of claim 11 wherein said substance is applied to the predetermined abrasion area.

15. The system of claim 14 wherein said substance is applied prior to abrasion.

16. The system of claim 14 wherein said substance is applied during abrasion.

17. The system of claim 14 wherein said substance is applied following abrasion.

18. The system of claim 14 wherein said microprotrusions are at least partially coated with said substance to be delivered.

19. The system of claim 11 wherein said skin template further comprises an opening.

20. The system of claim 12 wherein said cover is coated a substance selected from the group consisting of drug, vaccine, and bioactive substance.

21. The system of claim 12 wherein said cover is coated with a releasable retention means for retaining a substance selected from the group consisting of drug, vaccine, and bioactive substance.

22. A device for introducing a substance into skin of a patient through an abraded area, said device comprising:

a skin dressing having a central depression;

a substance selected from the group consisting of drug, vaccine, and bioactive substance;

a dome coupled to said skin dressing and overlying said abraded area and being spaced from said closure to define a cavity therebetween, and a piercing member; and

,

a reservoir adapted for containing at least one swellable material and being positioned in said cavity and adapted for containing said substance, said reservoir being pierceable by said piercing member and deformable by swelling of said swellable material wherein expansion of said swellable material dispenses said substance into said skin through said abraded area.

23. The device of claim 22 further comprising skin piercing members, wherein said skin piercing members are contained within said reservoir and are adapted to penetrate the skin by swelling of said swellable material.

24. The device of claim 23 wherein said skin piercing members are at least partially coated with said substance to be delivered.