Intra-arterial catheter for drug delivery
First Claim
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1. A steerable device comprising or which comprises a proximal double-lumen assembly and a balloon, wherein the first lumen of the double-lumen assembly is a micro-catheter and the second lumen of the double-lumen assembly is a larger lumen for inflating and deflating the balloon, and wherein the balloon can be rapidly inflated and deflated.
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Abstract
The present invention provides a catheter, a drug delivery system and methods for the localized delivery of therapeutic or diagnostic agent to a target location in a subject and methods for the treatment of a pathological disorder in a subject using the same.
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Citations
103 Claims
- 1. A steerable device comprising or which comprises a proximal double-lumen assembly and a balloon, wherein the first lumen of the double-lumen assembly is a micro-catheter and the second lumen of the double-lumen assembly is a larger lumen for inflating and deflating the balloon, and wherein the balloon can be rapidly inflated and deflated.
- 13. A drug delivery system comprising a steerable device and a balloon drive, wherein the steerable device comprises a proximal double-lumen assembly and a balloon, wherein the first lumen of the double-lumen assembly is a micro-catheter and the second lumen of the double-lumen assembly is a larger lumen for inflating and deflating the balloon, and wherein the balloon can be rapidly inflated and deflated.
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30. A method for the localized delivery of at least one agent to a target location within a subject, comprising the steps of:
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(1) partially or completely arresting blood flow to the target location for a short period of time;
(2) delivering the at least one agent in bolus to the target location; and
(3) partially or completely restoring blood flow to the target tissue, (4) wherein the blood flow is arrested by occluding the artery to the target tissue. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
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46. A method for the localized delivery of at least one agent to a target location within a subject, comprising the steps of:
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(1) providing a drug delivery system comprises a steerable device and a balloon drive, wherein the catheter comprises a proximal double-lumen assembly and a balloon, wherein the first lumen of the double-lumen assembly is a micro-catheter and the second lumen of the double-lumen assembly is a larger lumen for inflating and deflating the balloon, and wherein the balloon can be rapidly inflated and deflated;
(2) incorporating the at least one agent into the drug delivery system; and
(3) delivering the at least one agent to the target location. - View Dependent Claims (47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67)
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68. A method for the localized delivery of an agent to a target location within a subject, comprising the steps of:
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(1) providing a drug delivery system comprises a catheter and a balloon drive, wherein the catheter comprises a proximal double-lumen assembly and a balloon, wherein the first lumen of the double-lumen assembly is a micro-catheter and the second lumen of the double-lumen assembly is a larger lumen for inflating and deflating the balloon, and wherein the balloon can be rapidly inflated and deflated;
(2) incorporating the agent into the drug delivery system;
(3) occluding blood flow to the target location by inflating the balloon;
(4) delivering the agent in bolus to the target location; and
(5) deflating the balloon after a short period of time.
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69. A method for the treatment of a pathological disorder in a subject, comprising the steps of:
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(1) partially or completely arresting blood flow to a target tissue for a short period of time;
(2) delivering at least one therapeutic agent in bolus; and
(3) partially or completely restoring blood flow to the target tissue, wherein the target tissue has a pathological condition and the blood flow is arrested by occluding the artery to the target tissue, and wherein the at least one therapeutic agent is delivered into the target tissue or a location within the artery which is close to the target tissue. - View Dependent Claims (70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81)
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82. A method for the treatment of a pathological disorder in a subject, comprising the steps of:
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(1) providing a drug delivery system comprises a steerable device and a balloon drive, wherein the steerable device comprises a proximal double-lumen assembly and a balloon, wherein the first lumen of the double-lumen assembly is a micro-catheter and the second lumen of the double-lumen assembly is a larger lumen for inflating and deflating the balloon, and wherein the balloon can be rapidly inflated and deflated;
(2) incorporating at least one therapeutic agent into the drug delivery system; and
(3) delivering the at least one therapeutic agent to a target location, wherein the target location is in or close to a target tissue in the subject, wherein the target tissue has a pathological condition. - View Dependent Claims (83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101)
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102. A method for the treatment of a pathological disorder in a subject, comprising the steps of:
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(1) providing a drug delivery system comprises a catheter and a balloon drive, wherein the catheter comprises a proximal double-lumen assembly and a balloon, wherein the first lumen of the double-lumen assembly is a micro-catheter and the second lumen of the double-lumen assembly is a larger lumen for inflating and deflating the balloon, and wherein the balloon can be rapidly inflated and deflated;
(2) incorporating at least one therapeutic agent into the drug delivery system;
(3) occluding blood flow to the target location by inflating the balloon;
(4) delivering the at least one therapeutic agent to the target location; and
(5) deflating the balloon after a short period of time. - View Dependent Claims (103)
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Specification