Push-pull operated pump for a microfluidic system

• US 20060051218A1
• Filed: 09/06/2005
• Published: 03/09/2006
• Est. Priority Date: 09/06/2004
• Status: Abandoned Application

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Inventors: Harttig, Herbert
• Application Number:
  US11/220,293
• Publication Number:
  US 20060051218A1
• Time in Patent Office: Days
• US Class Current: 417/412
• CPC Class Codes: A61M 2205/0244 Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
• CPC Class Codes: A61M 5/14228 with linear peristaltic action, i.e. comprising at least three pressurising members or a helical member
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2400/0481 squeezing of channels or chambers
• CPC Class Codes: B01L 3/50273 characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043
• CPC Class Codes: F04B 19/006 Micropumps F04B43/043 and F04B43/095 take precedence
• CPC Class Codes: G01N 2035/1034 Transferring microquantities of liquid

Abstract

The present invention generally relates to a micropump for the conveyance of fluidic media at low flow rates. The micropump comprises at least one flow duct. The flow duct also has at least three pinch areas. The micropump also includes at least three actuators for the pumping of fluidic media. The actuators are configured and arranged in such a way that a force can be exerted on the flow duct by at least one of the actuators in each of the three pinch regions. This results in the flow duct being narrowed or completely closed at the pinched points and the fluid which is located in this region is completely or partially displaced from this pinched region.

Claims

1. A micropump for pumping of a fluidic media, the micropump comprising:

at least one flow duct having at least one wall body;

at least one pinch region in the at least one flow duct; and

at least one actuator, wherein the at least one actuator is capable of exerting force in the at least one pinch region such that a cross-sectional area of the at least one flow duct being capable of being varied in the at least one pinch regions by the force exerted by the at least one actuator.

2. The micropump according to claim 1, further comprising at least one casing, wherein the at least one casing completely or partially surrounds the at least one flow duct.

3. The micropump according to claim 1, wherein the at least one flow duct has a round or elliptical or lenticular cross-sectional area, such that a radius or lengths of a semi-axes of the cross-sectional area is in a range of between 10 micrometers and 1000 micrometers.

4. The micropump according to claim 1, wherein the number of at least one actuators corresponds to the number of at least one pinch region.

5. The micropump according to claim 1, wherein when the force is exerted on the at least one flow duct in at least one pinch region, a fluid located in the at least one flow duct is displaced completely or partially out of the at least one pinch region.

6. The micropump according to claim 1, wherein the at least one wall body comprises completely or partially an elastomer material.

7. The micropump according to claim 1, wherein the at least one wall body comprises completely or partially a silicone.

8. The micropump according to claim 7, wherein the silicone is a cold-curable dimethylsiloxane.

9. The micropump according to claim 1, wherein the at least one pinch region is arranged along a longitudinal axis of the at least one flow duct.

10. The micropump according to claim 1, further comprising at least three pinch regions and at least three actuators.

11. The micropump according to claim 10, wherein the force exerted by the at least three actuator in the at least three pinch regions takes place periodically at an actuator frequency which is identical for all the actuators.

12. The micropump according to claim 1, wherein the at least one flow duct has at least two connection regions, wherein the at least two connection regions are for connecting the at least one flow duct to a supply system and a discharge system for the fluidic media.

13. The micropump according to claim 1, having a volumetric flow rate of between 0 to 1000 nl/min.

14. The micropump according to claim 1, wherein at least one actuator is a bimetal actuator.

15. The micropump according to claim 14, wherein the shape of the bimetal actuator can be varied as a result of the application of an electric voltage and/or the conduction of an electrical current such that the magnitude of the force exerted on the at least one flow duct is set by means of the intensity of the electrical voltage and/or of the electrical current.

16. The micropump according to claim 14, wherein the bimetal actuator has a tongue shape.

17. The micropump according to claim 1, wherein at least one actuator is a thermal actuator.

18. The micropump according to claim 17, wherein the thermal actuator comprises at least one heat source and a homogeneous expansion region of the at least one wall body, wherein the at least one heat source is capable of locally raising the temperature of the homogeneous expansion region, such that density of the homogeneous expansion region of the at least one wall body being locally reduced that results in narrowing the cross-sectional area of the at least one flow duct in the at least one pinch region.

19. The micropump according to claim 18, wherein the at least one heat source is an electrically heatable resistor, wherein a temperature of the electrically heatable resistor is capable of being set as a result of an application of an electrical voltage and/or the conduction of an electrical current such that the degree of narrowing of the cross-sectional area of the at least one flow duct is set by the intensity of the electrical voltage and/or of the electrical current.

20. The micropump according to claim 17, wherein the thermal actuator has an SMD resistor.

21. The micropump according to claim 17, having a double-walled theremally insulating casing such that the thermally insulating casing completely or partially surrounds the at least one pinch region and the thermal actuator.

22. The micropump according to claim 17, wherein the at least one wall body has a material which has a linear coefficient of thermal expansion of between 0.01 and 0.09%/K.

23. The micropump according to claim 1, wherein the at least one actuator is a magnetic actuator.

24. The micropump according to claim 23, wherein the magnetic actuator comprises:

at least one force transmission element integrated into the at least one wall body such that at least one force transmission element being configured in such a way that a force can be exerted on the force transmission element as a result of the action of a magnetic field;

at least one magnetic-field generation element, wherein the at least one magnetic-field generation element generating a magnetic field of variable intensity; and

wherein the magnetic field being capable of acting on the at least one force transmission element.

25. The micropump according to claim 24, wherein the force transmission element has a ferromagnetic material.

26. The micropump according to claim 24, wherein the force transmission element has a ferromagnetic powder, the ferromagnetic powder being embedded into the at least one wall body.

27. The micropump according to claim 24, wherein the magnetic-field generation element further comprises:

at least one pumping magnet, wherein the at least one pumping magnet is capable of being variable in its spatial position and/or its orientation;

at least one pumping magnet generating a magnetic field which acts on the at least one force transmission element, wherein the magnetic field generated by the at least one pumping magnet at the location of the at least one force transmission element being dependent on the position and/or orientation of the at least one pumping magnet; and

at least one control magnet, that is capable of setting the spatial position and/or the orientation of the at least one pumping magnet.

28. The micropump according to claim 27, wherein the at least one pumping magnet has at least one permanent magnet.

29. The micropump according to claim 28, wherein all the permanent magnets have a common magnetic orientation.

30. The micropump according to claim 27, wherein the at least one pumping magnet has at least two different positions or orientations, such that the at least one pumping magnet acting mechanically on at least one wall body in such a way that, in at least one of the at least two positions or orientations of the at least one pumping magnet in at least one pinch region, the at least one flow duct has a cross-sectional area other than in the at least one other position or orientation of the at least one pumping magnet.

31. The micropump according to claim 27, wherein the at least one control magnet comprises:

at least one spatially moveable device, and

at least three magnetic elements connected to the spatially moveable device.

32. The micropump according to claim 31, wherein the spatially moveable device has a rotor disc such that the magnetic elements are arranged on the rotor disc along a circular path.

33. The micropump according to claim 30, wherein the at least three magnetic elements have a common preferred axis and are divided into groups with identical magnetic polarization such that the number of magnetic elements in each group does not overshoot the number of pumping magnets, reduced by one.

49. The micropump according to claim 1, wherein the actuator is a magnetic actuator.

34. A micropump for pumping of a fluidic media, the micropump comprising:

a flow duct having a wall body;

a pinch region in the flow duct;

an actuator, wherein the actuator is capable of exerting force in the pinch region such that a cross-sectional area of the flow duct being capable of being varied in the pinch regions by the force; and

an electronic control for activating the actuator.

35. The micropump according to claim 34, further comprising a casing, the casing completely or partially surrounds flow duct.

36. The micropump according to claim 34, wherein the flow duct has a round or elliptical or lenticular cross-sectional area, such that a radius or lengths of a semi-axes of the cross-sectional area is in a range of between 10 micrometers and 1000 micrometers.

37. The micropump according to claim 34, wherein the number actuators corresponds to the number of the pinch region.

38. The micropump according to claim 34, wherein when the force is exerted on the flow duct in the pinch region, a fluid located in the flow duct is displaced completely or partially out of the pinch region.

39. The micropump according to claim 34, wherein the wall body comprises completely or partially of an elastomer material.

40. The micropump according to claim 34, wherein the wall body comprises completely or partially a silicone.

41. The micropump according to claim 40, wherein the silicone is a cold-curable dimethylsiloxane.

42. The micropump according to claim 34, wherein the pinch region is arranged along a longitudinal axis of the flow duct.

43. The micropump according to claim 34, further comprising at least three pinch regions and at least three actuators.

44. The micropump according to claim 34, having a volumetric flow rate of between 0 to 1000 nl/min.

45. The micropump according to claim 34, wherein the actuator is a bimetal actuator.

46. The micropump according to claim 45, wherein the bimetal actuator has a tongue shape.

47. The micropump according to claim 34, wherein the actuator is a thermal actuator.

48. The micropump according to claim 34, wherein the wall body has a material which has a linear coefficient of thermal expansion of between 0.01 and 0.09%/K.

50. A micropump for pumping of a fluidic media, the micropump comprising:

a flow duct having a wall body;

more than one pinch region in the flow duct; and

more than one actuator, wherein the actuator is capable of exerting force in the pinch region such that a cross-sectional area of the flow duct being capable of being varied in the pinch regions by the force exerted by the actuator.

51. The micropump according to claim 50, wherein:

a number of N pinch regions are distributed along the longitudinal axis of the flow duct;

a flow path of length X_i-j occurring between the i'"'"'th and the j'"'"'th pinch region, with the relation i<

j, and i, jε

{I, . . . , N}, to apply, and i and j are to be integers;

the phase angle φ

_i-j of the phase shift of the force action between the i'"'"'th and the j'"'"'th pinch region being proportional to the length X_i-j with a proportionality factor k_i-j, and

the proportionality factor k_i-j being identical for all i, jε

{I, . . . , N}.

52. The micropump according to claim 50, wherein at each time point, the flow duct is closed in at least one pinch region.

53. The micropump according to claim 50, wherein the pinch regions are distributed equidistantly along the longitudinal axis, and the phase angle of the phase shift of the force action between two adjacent pinch regions amounts to 360°

divided by the number of pinch regions.

54. The micropump according to claim 50, wherein the number of actuators correspond to the number of the pinch region.

55. A method for production of a micropump for the pumping of fluidic media, the method comprising:

producing a casing using the a microinjection-moulding method;

introducing at least one actuator into the casing;

introducing at one flow-duct master moulding into the casing;

filling the casing with an elastic material; and

removing the at least one flow-duct master moulding from the casing.

56. The method according to claim 55, further comprising the step of coating at least one surface of the at least one casing and/or of the at least one actuator with an adhesion promoter layer.

57. The method according to claim 55, further comprising the step of coating at least one surface of the at least one flow-duct master moulding with an anti-adhesion layer.

58. The method according to claim 55, wherein he elastic material is silicone.

59. The method according to claim 58, wherein the silicone is cold-curable dimethylsiloxane.

60. The method according to claim 55, wherein the actuators introduced into the casing is a selected from a group consisting of a bimetal actuator, a thermal actuator or a magnetic actuator.