Metallic structures incorporating bioactive materials and methods for creating the same
First Claim
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1. A method comprising:
- providing a first bath comprising metal ions and at least one bioactive material wherein said metal ions and said at least one bioactive material in said first bath are provided at a first ratio;
contacting a substrate with said first bath;
forming a bioactive composite structure with a first concentration of metal ions and said at least one bioactive material on said substrate using an electrochemical process;
altering said first ratio between said metal ions and said at least one bioactive material to form a second ratio;
continuing to form said bioactive composite structure on said substrate using an electrochemical process but with a second concentration of metal ions and said at least one bioactive material.
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Abstract
Disclosed herein are methods to create medical devices and medical devices including bioactive composite structures. The methods include using electroless and electrophoretic deposition and codeposition methods for providing implantable medical devices coated with bioactive composite structures. In one use, the implantable medical devices of the present invention include stents with bioactive composite structures.
100 Citations
22 Claims
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1. A method comprising:
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providing a first bath comprising metal ions and at least one bioactive material wherein said metal ions and said at least one bioactive material in said first bath are provided at a first ratio;
contacting a substrate with said first bath;
forming a bioactive composite structure with a first concentration of metal ions and said at least one bioactive material on said substrate using an electrochemical process;
altering said first ratio between said metal ions and said at least one bioactive material to form a second ratio;
continuing to form said bioactive composite structure on said substrate using an electrochemical process but with a second concentration of metal ions and said at least one bioactive material. - View Dependent Claims (2, 3, 4)
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5. A method comprising:
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providing a first bath comprising metal ions and at least one bioactive material at a first ratio wherein said metal ions and said at least one bioactive material comprise a positive charge;
contacting a substrate with said first bath;
applying a negative charge to said substrate;
forming a bioactive composite structure on said substrate using an electrochemical process. - View Dependent Claims (6, 7, 8, 9, 10, 11)
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12. A medical device formed by a method comprising:
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providing a first bath comprising metal ions and at least one bioactive material wherein said metal ions and said at least one bioactive material in said first bath are provided at a first ratio;
contacting a substrate with said first bath;
forming a portion of a bioactive composite structure with a first concentration of metal ions and said at least one bioactive material on said substrate using an electrochemical process;
altering said first ratio between said metal ions and said at least one bioactive material to form a second ratio; and
continuing to form said bioactive composite structure on said substrate using an electrochemical process but with a second concentration of metal ions and said at least one bioactive material. - View Dependent Claims (13, 14, 15)
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16. A medical device formed by a method comprising:
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providing a first bath comprising metal ions and at least one bioactive material at a first ratio wherein said metal ions and said at least one bioactive material comprise a positive charge;
contacting a substrate with said first bath;
applying a negative charge to said substrate;
forming a bioactive composite structure on said substrate using an electrochemical process. - View Dependent Claims (17, 18, 19, 20, 21, 22)
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Specification