Homogeneous solid granules containing carotenoids

• US 20060051479A1
• Filed: 12/08/2003
• Published: 03/09/2006
• Est. Priority Date: 12/26/2002
• Status: Abandoned Application

• Current Assignee: Adisseo France S.A.S. (China National Chemical Corporation)
• Original Assignee: Adisseo France S.A.S. (China National Chemical Corporation)
• Inventors: Chiavazza, Veronique, Dollat, Jean-Marie, Fayard, Sylvie
• Application Number:
  US10/536,182
• Publication Number:
  US 20060051479A1
• Time in Patent Office: Days
• US Class Current: 426/541
• CPC Class Codes: A23L 29/284 Gelatin; Collagen
• CPC Class Codes: A23L 33/105 Plant extracts, their artificial duplicates or their derivatives
• CPC Class Codes: A23L 5/44 using carotenoids or xanthophylls
• CPC Class Codes: A23P 10/30 Encapsulation of particles, e.g. foodstuff additives
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/224 Encapsulating agent
• CPC Class Codes: A23V 2250/1628 Silicium
• CPC Class Codes: A23V 2250/1886 Stearic acid
• CPC Class Codes: A23V 2250/21 Plant extracts
• CPC Class Codes: A23V 2250/211 Carotene, carotenoids
• CPC Class Codes: A23V 2250/5432 Gelatine
• CPC Class Codes: A23V 2250/61 Glucose, Dextrose
• CPC Class Codes: A23V 2250/612 Lactose
• CPC Class Codes: A61K 9/1623 Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
• CPC Class Codes: A61K 9/1658 Proteins, e.g. albumin, gelatin
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals

Abstract

The homogeneous solid granules of the invention comprise at least 5% (w/w) of carotenoid, gelatine and a sugar, they have a size distribution of from 100 μm to 2000 gm and are solvent-free. The process for producing such granules comprises the following steps: (a) preparing an aqueous solution of at least gelatine and a sugar, (b) adding at least said carotenoid in said aqueous solution, (c) adding the preparation obtained in (b) to an oil to obtain an emulsion of granules, (d) cooling said emulsion to solidify the granules, and (e) recovering and drying the granules.

Claims

1-38. -38. (canceled)

39. Homogeneous solid solvent-free granules having a size distribution of from 100 μ

m to 2000 μ

m comprising at least 5% (w/w) of carotenoid, gelatine and a sugar.

40. The granules of claim 39, wherein said carotenoid is selected from the group consisting of lutein, zeaxanthin and their mixtures, in their free form and/or their esterified form.

41. The granules of claim 39, wherein said carotenoid is an oleoresin comprising at least esterified lutein and esterified zeaxanthin.

42. The granules of claim 40, wherein said carotenoid is a saponified oleoresin comprising at least free lutein and free zeaxanthin.

43. The granules of claim 40, wherein said carotenoid is purified crystallized lutein.

44. The granules of claim 39, wherein the amount of carotenoid varies between 5 to 30% (w/w).

45. The granules of claim 44, wherein the amount of carotenoid varies from 10 to 20% (w/w).

46. The granules of claim 39, wherein the amount of gelatine varies from 15 to 50% (w/w).

47. The granules of claim 39, wherein the amount of sugar varies from 10 to 50% (w/w).

48. The granules of claim 39, further comprising at least a fatty material selected from the group consisting of fatty acids, fatty esters, derivatives thereof and waxes.

49. The granules of claim 39, further comprising at least one antioxidant.

50. The granules of claim 49, wherein said antioxidant is selected from the group consisting of rosemary extracts, wine polyphenols extracts, ascorbic acid, sodium ascorbate, ascorbyl palmitate, tocopherols, derivatives of tocopherols, vitamin C, 3-tertiary butyl-4-hydroxyanisole (BHA), 3,5-di-tertiary-4-hydroxytoluene (BHT), 6-ethoxy-1,2-dihydroxy-2,2,4-trimethylquinoline (ethoxyquine).

51. The granules of claim 49, wherein the antioxidant amounts up to 10% (w/w).

52. The granules of claim 39, comprising a finite amount of water less than 10% (w/w).

53. A process for producing homogeneous solid granules as defined in claim 39, said process comprising the following steps:

(a) preparing an aqueous solution of at least gelatine and a sugar,

(b) adding at least said carotenoid in said aqueous solution,

(c) adding the preparation obtained in (b) to an oil to obtain an emulsion of granules,

(d) cooling said emulsion to solidify the granules, and

(e) recovering and drying the granules.

54. The process of claim 53, wherein said oil of step (c) is a vegetable oil selected from the group consisting of rapeseed oil, corn oil, sunflower oil, soybean oil, palm oil and any ester thereof.

55. The process of claim 53, wherein said carotenoid is selected from the group consisting of lutein, zeaxanthin and their mixtures, in their free form and/or their esterified form.

56. The process of claim 55, wherein said carotenoid is an oleoresin comprising at least esterified lutein and esterified zeaxanthin.

57. The process of claim 55, wherein said carotenoid is a saponified oleoresin comprising at least free lutein and free zeaxanthin.

58. The process of claim 56, wherein the oleoresin is obtained from Marigold flowers and tomato.

59. The process of claim 55, wherein said carotenoid is purified crystallized lutein.

60. The process of claim 55, wherein the amount of carotenoid added to the aqueous solution is such that the amount of said carotenoid in said granules is from 5 to 30% (w/w).

61. The process of claim 60, wherein said carotenoid amounts from 10 to 20% (w/w) in said granules.

62. The process of claim 53, wherein before adding the carotenoid to the aqueous solution, said carotenoid is mixed with a fatty material selected from the group consisting of fatty acids, fatty esters, derivatives thereof and waxes.

63. The process of claim 62, wherein said fatty material has a vegetable origin.

64. The process of claim 62, wherein said fatty acid is selected from the group consisting of stearic acid, and the mixtures of stearic acid and palmitic acid.

65. The process of claim 53, wherein the amount of gelatine in the in aqueous solution is such that the gelatine amounts from 15 to 50% (w/w) in said granules.

66. The process of claim 65, wherein the amount of gelatine in said granules is from 30 to 45% (w/w).

67. The process of claim 53, wherein the sugar is selected from the group consisting of polyols, monosaccharides, disaccharides, glucose syrups and maltodextrines.

68. The process of claim 67, wherein the polyols are selected from the group consisting of glycerol, sorbitol, maltitol and xylitol;

the monosaccharides are selected from the group consisting of fructose and glucose; and

the disaccharides are selected from the group consisting of lactose, maltose and sucrose.

69. The process of claim 53, wherein the amount of sugar in the aqueous solution is such that the sugar amounts from 10 to 50% (w/w) in the granules.

70. The process of claim 53, wherein the aqueous solution is prepared at a temperature from 50 to 70°

C.

71. The process of claim 55, wherein before adding the carotenoid to the aqueous solution, said carotenoid is mixed with at least one antioxidant.

72. The process of claim 71, wherein said antioxidant is miscible with oil and is selected from the group consisting of rosemary extracts, wine polyphenols extracts, ascorbic acid, sodium ascorbate, ascorbyl palmitate, tocopherols, derivatives of tocopherols, vitamin C, 3-tertiary butyl-4-hydroxyanisole (BHA), 3,5-di-tertiary-4-hydroxytoluene (BHT), 6-ethoxy-1,2-dihydroxy-2,2,4-trimethylquinoline (ethoxyquine).

73. The process of claim 72, wherein the amount of said antioxidant is such that it amounts up to 10% (w/w) in said granules.

74. The process of claim 53, wherein at step (d), the emulsion is cooled at a temperature below the glass transition temperature of the gelatine.

75. The process of claim 53, comprising a further step of adding a gelatine-crosslinking agent before step (e).

76. Nutraceutical composition comprising granules as defined in claim 39.