Methods for predicting outcome in traumatic brain injury
First Claim
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1. A method for predicting outcome for a subject suffering from traumatic brain injury (TBI) comprising the steps of;
- (a) obtaining a sample of body fluid from said subject;
(b) contacting said sample of body fluid with an antibody that specifically binds a β
subunit of S-100 protein, said antibody immobilized on a solid support; and
(c) determining binding of said antibody to said β
subunit of S-100 protein in said sample of body fluid wherein a level of said β
subunit of S-100 protein elevated above 39 pg/mL predicts outcome for a subject suffering from traumatic brain injury (TBI).
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Abstract
The invention describes methods for predicting outcome for patients suffering from traumatic brain injury (TBI) by evaluating levels of markers commonly associated with cellular damage in bodily fluids. Utilization of such methods improves diagnosis and treatment of patients suffering from traumatic brain injury, thus potentially minimizing and/or eliminating long-term adverse effects in these patients.
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Citations
9 Claims
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1. A method for predicting outcome for a subject suffering from traumatic brain injury (TBI) comprising the steps of;
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(a) obtaining a sample of body fluid from said subject;
(b) contacting said sample of body fluid with an antibody that specifically binds a β
subunit of S-100 protein, said antibody immobilized on a solid support; and
(c) determining binding of said antibody to said β
subunit of S-100 protein in said sample of body fluid wherein a level of said β
subunit of S-100 protein elevated above 39 pg/mL predicts outcome for a subject suffering from traumatic brain injury (TBI). - View Dependent Claims (2, 3, 4, 5)
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6. A method for predicting the existence of brain injury detected by a computer-assisted tomographic (CT) scan in a subject suffering from traumatic brain injury (TBI) comprising the steps of;
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(a) obtaining a sample of body fluid from said subject;
(b) contacting said sample of body fluid with an antibody that binds myelin basic protein (MBP), said antibody immobilized on a solid support; and
(c) determining binding of said antibody to said myelin basic protein (MBP) in said sample of body fluid wherein a level of said myelin basic protein (MBP) elevated above 76 pg/mL predicts the existence of brain injury detected by a computer-assisted tomographic (CT) scan in a subject suffering from traumatic brain injury. - View Dependent Claims (7, 8, 9)
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Specification