Implantable medical device with analgesic or anesthetic

• US 20060052757A1
• Filed: 09/27/2005
• Published: 03/09/2006
• Est. Priority Date: 06/04/1996
• Status: Abandoned Application

• Current Assignee: Vance Products Incorporated (Cook Group Incorporated)
• Original Assignee: Vance Products Incorporated (Cook Group Incorporated)
• Inventors: Andrews, Marvin O., Fischer, Frank J. Jr., Miller, Jessica Watts
• Application Number:
  US11/236,776
• Publication Number:
  US 20060052757A1
• Time in Patent Office: Days
• US Class Current: 604/265
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2250/0035 differing in release or diffusion time
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61K 51/1282 Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2300/45 Mixtures of two or more drugs, e.g. synergistic mixtures
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 25/0017 specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
• CPC Class Codes: A61M 25/0045 multi-layered, e.g. coated coating materials A61L29/08
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

An implantable medical device such as a catheter with a controlled-release outer layer including a pharmacologically active ingredient for helping to relieve pain associated with the implantation of the device. The device includes a base material with an outer bioactive material layer including, for example, an analgesic or a local anesthetic.

Claims

1. An implantable medical device, comprising:

a medical device for insertion into a patient;

an attachment layer on at least a portion of the medical device; and

a controlled-release outer layer on at least a portion of the attachment layer, wherein the controlled-release layer further comprises at least one analgesic compound.

2. The device of claim 1, wherein the analgesic compound is selected from the group consisting of aspirin and non-steroidal anti-inflammatory compounds.

3. The device of claim 1, wherein the controlled-release outer layer further comprises an antimicrobial compound selected from the group consisting of a penicillin, a cephalosporin, a carbepenem, a beta-lactam, an antibiotic, an aminoglycoside, a macrolide, a lincosamide, a glycopeptide, a tetracyline, a chloramphenicol, a quinolone, a fucidin, a sulfonamide, a trimethoprim, a rifamycin, an oxaline, a streptogramin, a lipopeptide, a ketolide, a polyene, an azole, and an echinocandin.

4. The device of claim 1, wherein the controlled-release outer layer further comprises an antimicrobial compound selected from the group consisting of alpha-terpineol, methylisothiazolone, cetylpyridinium chloride, chloroxyleneol, hexachlorophene, chlorhexidine and other cationic biguanides, methylene chloride, iodine and iodophores, triclosan, taurinamides, nitrofurantoin, methenamine, aldehydes, azylic acid, rifampycin, silver, benzyl peroxide, alcohols, and carboxylic acids and salts, silver sulfadiazine, an anthracycline, a fluoropyrimidine, a podophylotoxin, and an etoposide.

5. The device of claim 1, wherein the analgesic is selected from the group consisting of aspirin, naproxen, choline, diflunisal, salsalate, fenoprofen, flurbiprofen, ketoprofen, ibuprofen, oxaprozin, diclofenac, indomethacin, sulindac, acetoaminophen, tolmetin, meloxicam, piroxicam, meclofenamate, mefanimic acid, nabumetone, etodelac, keterolac, celecoxib, valdecoxib and rofecoxib, mixtures thereof, and derivatives thereof.

6. The device of claim 1, wherein the analgesic is selected from the group consisting of opioids, synthetic drugs with narcotic properties, and local anesthetics to include at least paracetamol, bupivacaine, ropivacaine, lidocaine, and novocaine.

7. The device of claim 1, wherein the medical device is selected from the group consisting of a ureteral stent, a urethral catheter, a biliary stent, a pancreatic stent, a catheter for suprapubic drainage, a catheter for nephrostomy drainage, a catheter for nasal pancreatic drainage, and a nasal biliary drainage catheter.

8. The device of claim 7, wherein walls of the medical device comprise a metallic coil or a polymer.

9. The device of claim 1, wherein the compound is released in measurable amounts over a period of at least one week.

10. The device of claim 1, wherein the controlled-release outer layer further comprises an anti-encrustation compound selected from the group consisting of heparin, covalent heparin, dexamethazone, dexamethasone sodium phosphate, dexamethasone acetate and another dexamethasone derivative.

11. The device of claim 1, wherein the controlled-release outer layer further comprises an anti-encrustation compound, an antispasmodic compound, or an antiseptic compound.

12. The device of claim 1, wherein the controlled-release outer layer further comprises an anti-encrustation compound selected from the group consisting of triclosan, silver nitrate, ofloxacin, ciproflaxin, phosphorylcholine and triemethoprim.

13. An implantable medical device, comprising:

a medical device for insertion into a patient;

an attachment layer on at least a portion of the medical device; and

a controlled-release outer layer on at least a portion of the attachment layer, wherein the controlled-release outer layer comprises an analgesic and an additional compound.

14. The implantable device of claim 13, wherein the additional compound is heparin, covalent heparin, dexamethazone, dexamethasone sodium phosphate, dexamethasone acetate or another dexamethasone derivative.

15. The implantable device of claim 13, wherein the analgesic is selected from the group consisting of non-steroidal anti-inflammatory drugs and aspirin.

16. The implantable device of claim 13, wherein the additional compound is gendine.

17. The implantable device of claim 13, wherein the additional compound is paclitaxel.

18. The implantable device of claim 13, wherein the additional compound is an anesthetic.

19. An implantable medical device, comprising:

a medical device for insertion into a patient;

an attachment layer on at least a portion of the medical device; and

a controlled-release outer layer on at least a portion of the attachment layer, wherein the controlled-release outer layer comprises an anesthetic.

20. The implantable medical device according to claim 19, wherein the anesthetic is selected from the group consisting of paracetamol, bupivacaine, ropivacaine, lidocaine, and novocaine

21. A method of treating a patient, the method comprising:

furnishing an implantable medical device with a controlled-release outer layer including an analgesic or an anesthetic; and

placing the device into the patient.

22. The method of claim 21, wherein the implantable medical device further comprises an analgesic.

23. The method of claim 21, wherein the implantable medical device further comprises a narcotic selected from the group consisting of alfentanil, buprenorphine, carfentanil, codeine, codeinone, dextropropoxyphene, dihydrocodeine, endorphin, fentanyl, hydrocodone, hydromorphone, methadone, morphine, morphinone, oxycodone, oxymorphone, pethidine, remifantanil, sulfentanil, thebaine, and tramadol, mixtures thereof, and derivatives thereof.