Liver stromal cells for prevention and treatment of immune responses in transplantation
First Claim
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1. A method of treating a transplant recipient to reduce in said recipient an immune response of effector cells against an alloantigen to the effector cells, the method comprising;
- administering to a transplant recipient liver stromal cells in an amount effective to reduce an immune response of effector cells against an alloantigen to the effector cells, whereby in the transplant recipient the effector cells have a reduced immune response against the alloantigen.
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Abstract
The present invention encompasses methods and compositions for reducing an immune response to a transplant in a recipient by treating said recipient with an amount of liver stromal cells effective to reduce or inhibit host rejection of the transplant. Also disclosed is a method of inducing a reduced immune response against a host by foreign tissue, i.e., graft versus host disease, by treatment with liver stromal cells.
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Citations
26 Claims
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1. A method of treating a transplant recipient to reduce in said recipient an immune response of effector cells against an alloantigen to the effector cells, the method comprising;
administering to a transplant recipient liver stromal cells in an amount effective to reduce an immune response of effector cells against an alloantigen to the effector cells, whereby in the transplant recipient the effector cells have a reduced immune response against the alloantigen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method for treating a transplant recipient to reduce in said recipient an immune response of effector cells against an alloantigen to the effector cells, the method comprising:
transplanting to a transplant recipient a transplant treated with liver stromal cells in an amount effective to reduce an immune response of effector cells against an alloantigen to the effector cells, whereby in the transplant recipient the effector cells have a reduced immune response against the alloantigen. - View Dependent Claims (24)
- 25. A method of reducing an immune response of effector cells against allogeneic cells, the method comprising treating the effector cells with liver stromal cells.
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