Low-obscuration image transmitting particulate ocular therapeutic formulations

• US 20060057216A1
• Filed: 09/15/2004
• Published: 03/16/2006
• Est. Priority Date: 09/15/2004
• Status: Abandoned Application

• Current Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Inventors: Salamone, Joseph C., Raiche, Adrian T.
• Application Number:
  US10/941,389
• Publication Number:
  US 20060057216A1
• Time in Patent Office: Days
• US Class Current: 424/489
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61K 9/5146 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
• CPC Class Codes: A61K 9/5153 Polyesters, e.g. poly(lactide-co-glycolide)

Abstract

Low-obscuration image transmitting particulate ocular therapeutic formulations are described. Additionally, methods are described for producing and for using such low-obscuration image transmitting particulate ocular therapeutic formulations.

Claims

1. A low-obscuration image transmitting ocular composition comprising:

particulates of about 0.10 to about 500 nm diameter at a concentration of about 0.01 to about 500 mg/ml for ocular therapeutic use.

6. The composition of claim 1, 2, 3, 4 or 5 further comprising a secondary material to alter said particulates for ocular use.

7. The composition of claim 1, 2 or 5 further comprising a secondary material to alter imaginary refractive index of said particulates for ocular use.

9. The composition of claim 1, 3 or 4 further comprising a secondary material to alter real refractive index of said particulates for ocular therapeutic use.

11. The composition of claim 1, 2 or 3 further comprising a secondary material to achieve said diameter of said particulates for ocular therapeutic use.

15. The composition of claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 further comprising a therapeutically active agent.

16. The composition of claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 wherein said particulates include a therapeutically active agent.

17. A method of using the composition of claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 or 16 comprising:

administering topically said composition to tissue.

18. A method of using the composition of claim 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 or 16 comprising:

administering parenterally said composition to tissue.

2. A low-obscuration image transmitting ocular composition comprising:

particulates of about 0.10 to about 500 nm diameter having a real refractive index of about 1.0 to about 1.8 at a concentration of about 0.01 to about 500 mg/ml for ocular use.

10. The composition of claim 2 or 5 further comprising a secondary material to achieve said real refractive index of said particulates.

13. The composition of claim 6, 7, 8, 9, 10, 11 or 12 wherein said one or more secondary materials are selected from the group consisting of polyolefins, polyethers, polyesters, polyanhydrides, polyamides, polyorthoesters, polyacrylates, polysulfones, polysiloxanes, polysaccharides, polyvinylpyrrolidone, polyols, alcohols, water, and inorganic compounds.

3. A low-obscuration image transmitting ocular composition comprising:

particulates of about 0.10 to about 500 nm diameter having an imaginary refractive index of less than about 0.20 or greater than about 0.30 at a concentration of about 0.01 to about 500 mg/ml for ocular use.

8. The composition of claim 3 or 4 further comprising a secondary material to achieve said imaginary refractive index of said particulates.

4. A low-obscuration image transmitting ocular composition comprising:

particulates of less than about 0.20 or greater than about 0.30 imaginary refractive index at a concentration of about 0.01 to about 500 mg/ml for ocular use.

12. The composition of claim 4 or 5 further comprising a secondary material to alter diameters of said particulates for ocular therapeutic use.

5. A low-obscuration image transmitting ocular composition comprising:

particulates of about 1.0 to about 1.8 real refractive index at a concentration of about 0.01 to about 500 mg/ml for ocular use.

14. An ocular composition comprising:

particulates of 10 mg/ml concentration having, while in an eye or surrounding tissues, less than 1 dB variation due to light scattering over 0.050 in the eye.