Sample collecting device and mass spectrometry of device
First Claim
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1. Sample collection device comprising an inert collection matrix capable of adsorbing or absorbing a fluid sample, and a solid support, wherein the inert matrix is affixed to an area of the solid support.
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Abstract
A sample collection device comprising a support bearing an inert absorbing matrix for a fluid sample is described. The device may or may not have a lancet. Also described for a sample device is a method of using a mass spectrometer in a laboratory where the sample in its matrix is ionised and the plurality of elements is detected. The results may or may not be quantised in relation to the original sample and an internal ionised reference sample may also be used.
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Citations
37 Claims
- 1. Sample collection device comprising an inert collection matrix capable of adsorbing or absorbing a fluid sample, and a solid support, wherein the inert matrix is affixed to an area of the solid support.
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14. A sample collection device having multi-layer construction wherein the collection matrix layer is sandwiched between two supporting layers, one of said supporting layers having an opening, which exposes an area of the collection matrix.
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17. Method of detecting simultaneously a plurality of elements in a fluid sample adsorbed onto or into an inert collection matrix, comprising:
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(i) exposing the sample to high energy radiation capable of ionising at least a portion of the sample, and (ii) detecting plurality of elements in the ionised portion of the sample by mass spectrometry. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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18. Method of quantifying simultaneously a plurality of elements in a fluid sample adsorbed onto or into an inert collection matrix, comprising:
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(i) exposing the sample to high energy radiation capable of ionising at least a portion of the sample;
(ii) measuring quantity of a plurality of elements in the ionised portion of the sample by mass spectrometry;
(iii) measuring quantity of ionised portion of sample, and (iv) determining quantity of the plurality of elements in the sample with reference to the quantity of ionised portion of the sample.
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19. Method of quantifying simultaneously a plurality of elements in a fluid sample adsorbed onto or into an inert collection matrix having an internal standard applied thereto, comprising:
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(i) exposing the sample to high energy radiation capable of ionising at least a portion of the sample and a portion of said internal standard;
(ii) measuring quantity of a plurality of elements in the ionised portion of the sample by mass spectrometry;
(iii) measuring quantity of ionised internal standard in the ionised portion of the sample by mass spectrometry, and (iv) determining quantity of the plurality of elements in the sample with reference to quantity of ionised internal standard. - View Dependent Claims (23, 24)
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20. Method of quantifying simultaneously a plurality of elements in a fluid sample adsorbed onto an inert collection matrix, comprising:
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(i) introducing into the fluid sample a known quantity of a measurable internal standard (ii) exposing the sample to high energy radiation capable of ionising at least a portion of the sample and the internal standard;
(iii) measuring quantity of a plurality of elements in the ionised portion of the sample by mass spectrometry;
(iv) measuring quantity of ionised internal standard in the ionised portion of the sample by mass spectrometry, and (v) determining quantity of the plurality of elements in the sample with reference to quantity of ionised internal standard.
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21. Method of quantifying simultaneously a plurality of elements in a fluid sample adsorbed/absorbed onto or into an inert collection matrix comprising:
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(i) exposing the sample to high energy radiation capable of ionising at least a portion of the sample;
(ii) measuring quantity of a plurality of elements in the ionised portion of the sample by mass spectrometry;
(iii) exposing a matrix-matched Certified Reference Material (CRM) to high energy radiation capable of ionising at least a portion of the CRM;
(iv) measuring quantity of ionised CRM in the ionised portion of the sample by mass spectrometry, and (v) determining quantity of the plurality of elements in the sample with reference to the CRM. - View Dependent Claims (25)
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22. Method of quantifying simultaneously a plurality of elements in a fluid sample supported on an impermeable substrate, comprising:
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(i) exposing the sample to high energy radiation capable of ionising at least a portion of the sample;
(ii) measuring quantity of a plurality of elements in the ionised portion of the sample by mass spectrometry;
(iii) exposing a matrix-matched Certified Reference Material (CRM) to high energy radiation capable of ionising at least a portion of the CRM;
(iv) measuring quantity of ionised CRM in the ionised portion of the sample by mass spectrometry, and (v) determining quantity of the plurality of elements in the sample with reference to the CRM.
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37. A method of collecting a fluid sample for mass spectrometry analysis of multiple element content comprising the application of the sample to an inert matrix having a low background element content, wherein the matrix is selected from the group consisting of aragonite, aluminium hydroxide, titania, glucose, Starch “
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, Starch “
B”
, glucodin, cellulose powder/granules, fibrous cellulose, hydroxy butyl methyl cellulose, vegetable flour or mixtures thereof.
- A”
Specification