Antibodies directed against amyloid-beta peptide and methods using same
First Claim
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1. A method for treating a disease characterized by aberrant deposition of β
- -amyloid in a subject, comprising administering to the subject an effective amount of an antibody that specifically binds to a β
-amyloid peptide or an aggregated form of a β
-amyloid peptide, wherein the antibody comprises an Fc region having impaired effector function.
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Abstract
Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer'"'"'s disease and Aβ peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer'"'"'s disease and Aβ peptide associated diseases are also described.
144 Citations
76 Claims
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1. A method for treating a disease characterized by aberrant deposition of β
- -amyloid in a subject, comprising administering to the subject an effective amount of an antibody that specifically binds to a β
-amyloid peptide or an aggregated form of a β
-amyloid peptide, wherein the antibody comprises an Fc region having impaired effector function. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
- -amyloid in a subject, comprising administering to the subject an effective amount of an antibody that specifically binds to a β
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26. A method for treating a disease associated with aberrant deposition of β
- -amyloid in a subject, comprising administering to the subject an effective amount of an antibody that specifically binds to a β
-amyloid peptide or an aggregated form of a β
-amyloid peptide, wherein the antibody comprises an Fc region with a variation from a naturally occurring Fc region, wherein the variation results in impaired effector function. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
- -amyloid in a subject, comprising administering to the subject an effective amount of an antibody that specifically binds to a β
-
49. An antibody comprising a heavy chain variable region comprising:
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(a) a CDR1 region shown in SEQ ID NO;
3;
(b) a CDR2 region shown in SEQ ID NO;
4; and
(c) a CDR3 region shown in SEQ ID NO;
5, wherein L1 is L, V, or I;
wherein Y2 is Y or W;
wherein S3 is S, T, or G;
wherein L4 is L, R, A, V, S, T, Q, or E;
wherein V6 is V, I, T, P, C, Q, S, N, or F; and
wherein Y7 is Y, H, F, W, S, I, V, or A.wherein the antibody specifically binds to an Aβ
peptide. - View Dependent Claims (50, 51, 52, 62, 63, 64, 65, 70, 71, 72, 73, 74, 75, 76)
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53. An antibody comprising a light chain variable region comprising:
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(a) a CDR1 region shown in SEQ ID NO;
6, wherein Y8 is Y, A, or H;
wherein A11 is A or S; and
wherein K12 is K or A;
(b) a CDR2 region shown in SEQ ID NO;
7; and
(c) a CDR3 region shown in SEQ ID NO;
8, wherein L1 is L, M, N, C, F, V, K, S, Q, G, S;
wherein G3 is G, S, or T;
wherein T4 is T or S;
wherein H5 is H or L;
wherein Y6 is Y, P, A, W, Q, M, S, or E;
wherein V8 is V, L, K, H, T, A, E, or M; and
wherein L9 is L, I, T, S, or V;
wherein the antibody specifically binds to an Aβ
peptide. - View Dependent Claims (54, 55, 56, 57, 58, 59, 60, 61, 66, 67, 68, 69)
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Specification