Esters of hydroxyl-substituted nitrogen heterocycles, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions

• US 20060058344A1
• Filed: 11/09/2005
• Published: 03/16/2006
• Est. Priority Date: 04/13/2002
• Status: Active Grant

• Current Assignee: Boehringer Ingelheim Pharma GmbH & Company Kg (C.H. Boehringer Sohn AG & Co. KG)
• Original Assignee: Boehringer Ingelheim Pharma GmbH & Company Kg (C.H. Boehringer Sohn AG & Co. KG)
• Inventors: Pieper, Michael P., Grauert, Matthias, Breitfelder, Steffen, Speck, Georg, Pohl, Gerald
• Granted Patent: US 7,429,601 B2
• Time in Patent Office: Days
• US Class Current: 514/304
• CPC Class Codes: A61K 31/46 8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: C07D 451/02 containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Abstract

The present invention relates to new compounds of general formula 1
wherein X⁻ and the groups A, B, R, R¹, R², R³, R^3′, R⁴, R^4′, R^x and R^x′ may have the meanings given in the claims and in the specification, processes for preparing them and their use as pharmaceutical compositions.

Claims

1-10. -10. (canceled)

11. Tropan-6exo-yl benzilate methobromide or a physiologically acceptable salt thereof.

12. Tropan-6exo-yl 9-hydroxy-fluorene-9-carboxilate methobromide or a physiologically acceptable salt thereof.

13. Tropan-6exo-yl 2-hydroxy-2,2-dithiophene-acetate methobromide or a physiologically acceptable salt thereof.

14. Tropan-6exo-yl 9-hydroxy-xanthene-9-carboxilate methobromide or a physiologically acceptable salt thereof.

15. Tropan-6endo-yl benzilate methobromide or a physiologically acceptable salt thereof.

16. Tropan-6endo-yl 9-hydroxy-fluorene-9-carboxylate methobromide or a physiologically acceptable salt thereof.

17. Tropan-6endo-yl 9-hydroxy-xanthene-9-carboxilate methobromide or a physiologically acceptable salt thereof.

18. Tropan-6endo-yl 2-hydroxy-2,2-dithiophene-acetate methobromide or a physiologically acceptable salt thereof.