Biological interface systems with wireless connection and related methods

• US 20060058627A1
• Filed: 08/11/2005
• Published: 03/16/2006
• Est. Priority Date: 08/13/2004
• Status: Abandoned Application

• Current Assignee: Cyberkinetics Neurotechnology Systems, Inc.
• Original Assignee: Cyberkinetics Neurotechnology Systems, Inc.
• Inventors: Flaherty, J. Christopher, Donoghue, John P.
• Application Number:
  US11/201,283
• Publication Number:
  US 20060058627A1
• Time in Patent Office: Days
• US Class Current: 600/409
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 2560/0271 using a remote monitoring unit
• CPC Class Codes: A61B 5/0017 transmitting optical signals transmission by light H04B10/00
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/398 Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
• CPC Class Codes: A61N 1/36003 of motor muscles, e.g. for walking assistance
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/361 Phantom sensations, e.g. tinnitus
• CPC Class Codes: G09B 21/00 Teaching, or communicating with, the blind, deaf or mute audible presentation of material to be studied G09B5/04; devices or methods for replacing direct visual or auditory perception by another kind of perception A61F9/08, A61F11/04; audible indication of meter readings or of colour G01D7/12; watches for blind persons G04B25/02; speech analysis, speech recognition G10L; sound-recording or reproducing, per se G11B
• CPC Class Codes: G16H 40/40 for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
• CPC Class Codes: G16H 40/63 for local operation

Abstract

Various embodiments of a biological interface system and their related methods are disclosed. A biological interface system may include a sensor including a plurality of electrodes configured to detect multicellular signals emanating from one or more living cells of a patient and a processing unit configured to receive the multicellular signals from the sensor, to process the multicellular signals to produce processed signals, and to transmit the processed signals. The system may also include a controlled device configured to receive the processed signals from the processing unit. The processing unit may include a processing unit first portion and a processing unit second portion, where the processing unit first portion is implanted under the scalp on the skull of the patient, and the processing unit second portion is placed above the scalp of the patient at a location proximal to the processing unit first portion.

Claims

1. A biological interface system comprising:

a sensor comprising a plurality of electrodes configured to detect multicellular signals emanating from one or more living cells of a patient, the sensor being implanted within the skull of the patient;

a processing unit configured to receive the multicellular signals from the sensor, to process the multicellular signals to produce processed signals, and to transmit the processed signals; and

a controlled device configured to receive the processed signals from the processing unit;

wherein the processing unit comprises a processing unit first portion and a processing unit second portion, and

wherein the processing unit first portion is implanted under the scalp on the skull of the patient, and the processing unit second portion is placed above the scalp of the patient at a location proximal to the processing unit first portion.

2. The system of claim 1, wherein the processing unit first portion is connected to the sensor with a bundle of electrically conductive wires.

3. The system of claim 2, wherein the wire bundle comprises a separate wire attached to each electrode.

4. The system of claim 1, wherein the processing unit first portion lacks an integrated supply of power.

5. The system of claim 1, wherein the processing unit first portion comprises an inductive coil.

6. The system of claim 5, wherein the inductive coil is configured to convert received electromagnetic signals to power.

7. The system of claim 5, wherein the inductive coil is configured to convert received electromagnetic signals to data.

8. The system of claim 1, wherein the processing unit first portion is configured to transmit information via an infrared communication element.

9. The system of claim 8, wherein the infrared communication element comprises an infrared light emitting diode.

10. The system of claim 9, wherein the processing unit first portion comprises one or more optical components to focus the emitted infrared light.

11. The system of claim 1, wherein the processing unit first portion comprises a signal processing circuitry.

12. The system of claim 11, wherein the signal processing circuitry is configured to perform one or more of:

amplification;

filtering;

sorting;

conditioning;

translating;

interpreting;

encoding;

decoding;

combining;

extracting;

sampling;

multiplexing;

analog to digital converting;

digital to analog converting;

mathematically transforming; and

processing cellular signals to generate a control signal for transmission to a controllable device.

13. The system of claim 1, wherein the processing unit first portion comprises an integrated power supply.

14. The system of claim 1, wherein the processing unit first portion comprises one or more of:

a temperature sensor;

a pressure sensor;

a strain gauge;

an accelerometer;

a volume sensor;

an electrode;

an array of electrodes;

an audio transducer;

a mechanical vibrator;

a drug delivery device;

a magnetic field generator;

a photo detector element;

a visualization apparatus;

a wireless communication element;

a light producing element;

an electrical stimulator;

a physiologic sensor;

a heating element; and

a cooling element.

15. The system of claim 1, wherein the processing unit first portion is configured to transmit information to the processing unit second portion with a wireless information transfer member.

16. The system of claim 15, wherein the processing unit second portion is external to the patient.

17. The system of claim 1, wherein the processing unit first portion is placed on the skull in close proximity to the ear of the patient.

18. The system of claim 1, wherein the processing unit first portion is placed in a recess surgically created on the top of the skull of the patient.

19. The system of claim 1, wherein the processing unit second portion comprises an integrated power supply.

20. The system of claim 1, wherein the processing unit second portion is configured to transmit the processed signals to the controlled device via wireless communication.

21. The system of claim 1, wherein the processing unit second portion comprises an infrared receiving element.

22. The system of claim 21, wherein the infrared receiving element comprises a photodiode.

23. The system of claim 21, wherein the infrared receiving element comprises one or more optical components used to collect the infrared light.

24. The system of claim 1, wherein the processing unit second portion comprises an inductive coil.

25. The system of claim 24, wherein the inductive coil is configured to send power to the processing unit first portion.

26. The system of claim 25, wherein the inductive coil is configured to send data to the processing unit first portion.

27. The system of claim 1, wherein the controlled device comprises a first controlled device and a second controlled device.

28. The system of claim 27, further comprising a selector module configured to select which of the first and second controlled devices is to be controlled by the processed signals.

29. The system of claim 1, wherein the system comprises a neural interface system.

30. The system of claim 1, wherein the system comprises a brain machine interface.

31. The system of claim 1, wherein the system is configured to perform a therapeutic function.

32. The system of claim 31, wherein the therapeutic function comprises a treatment of one or more of:

obesity, an eating disorder, a neurological disorder, a psychiatric disorder, a cardiovascular disorder, an endocrine disorder, sexual dysfunction, incontinence, a hearing disorder, a visual disorder, a sleeping disorder, a movement disorder, a speech disorder, physical injury, migraine headaches, and chronic pain.

33. The system of claim 1, wherein the system is configured to perform a patient diagnosis.

34. The system of claim 33, wherein the patient diagnosis comprises a diagnosis of one or more of:

obesity, an eating disorder, a neurological disorder, a psychiatric disorder, a cardiovascular disorder, an endocrine disorder, sexual dysfunction, incontinence, a hearing disorder, a visual disorder, sleeping disorder, a movement disorder, a speech disorder, physical injury, migraine headaches, and chronic pain.

35. The system of claim 1, wherein the system is configured to restore a bodily function of the patient.

36. The system of claim 35, wherein the bodily function of the patient comprises one or more of vision, hearing, speech, communication, limb motion, ambulation, reaching, grasping, standing, rolling over, bowel movement, and bladder evacuation.

37. The system of claim 1, wherein the system is configured to be turned on and off by the patient with a monitored biological signal.

38. The system of claim 37, wherein the monitored biological signal is generated by one or more of eye motion, eyelid motion, facial muscle, or other electromyographic activity.

39. The system of claim 37, wherein the monitored biological signal comprises a time code of brain activity.

40. The system of claim 1, wherein the multicellular signals emanate from the central nervous system of the patient.

41. The system of claim 1, wherein the multicellular signals emanate from a single cell of the patient.

42. The system of claim 1, wherein the multicellular signals comprise one or more of:

neuron spikes, electrocorticogram signals, local field potential signals, and electroencephalogram signals.

43. The system of claim 1, wherein the electrodes are configured to detect the multicellular signals from clusters of neurons and provide signals between single neuron and electroencephalogram recordings.

44. The system of claim 1, wherein the processing unit is configured to assign at least one cellular signal to a specific use.

45. The system of claim 1, wherein the processing unit is configured to use at least one cellular signal generated under voluntary control of a patient.

46. The system of claim 1, wherein the patient is a human being.

47. The system of claim 1, wherein the patient is one or more of:

a quadriplegic, a paraplegic, an amputee, a spinal chord injury victim, and a physically impaired person.

48. The system of claim 1, wherein the patient is healthy, and the system is not configured to provide a therapeutic or restorative function to the patient.

49. The system of claim 48, wherein the controlled device comprises a medical equipment.

50. The system of claim 49, wherein the medical equipment is configured to perform a surgical event.

51. The system of claim 48, wherein the controlled device comprises a communication device.

52. The system of claim 51, wherein the communication device is configured to transmit different pieces of information simultaneously.

53. The system of claim 48, wherein the controlled device comprises a piece of equipment with one or more controllable moving parts.

54. The system of claim 53, wherein the equipment is used to evacuate personnel.

55. The system of claim 53, wherein the equipment is used to diffuse a bomb.

56. The system of claim 53, wherein the equipment is used to provide a military function.

57. The system of claim 53, wherein the equipment is one or more of a:

watercraft, aircraft, land vehicle, and reconnaissance robot.

58. The system of claim 1, wherein the controlled device comprises one or more of the group consisting of:

a computer, a computer display, a mouse, a cursor, a joystick, a personal data assistant, a robot or robotic component, a computer controlled device, a teleoperated device, a communication device, a vehicle, an adjustable bed, an adjustable chair, a remote controlled device, a Functional Electrical Stimulator device, a muscle stimulator, an exoskeletal robot brace, an artificial or prosthetic limb, a vision enhancing device, a vision restoring device, a hearing enhancing device, a hearing restoring device, a movement assist device, a medical therapeutic equipment, a drug delivery apparatus, a medical diagnostic equipment, a bladder control device, a bowel control device, a human enhancement device, and a closed loop medical equipment.

59. The system of claim 1, wherein the sensor comprises at least one multi-electrode array comprising the plurality of electrodes.

60. The system of claim 59, wherein the plurality electrodes are arranged in a ten by ten array.

61. The system of claim 59, wherein the plurality of electrodes are configured to penetrate into neural tissue of the brain to detect electric signals generated from neurons.

62. The system of claim 59, wherein the multi-electrode array comprises at least one of a recording electrode, a stimulating electrode, and an electrode having recording and stimulating capabilities.

63. The system of claim 59, wherein the multi-electrode array comprises multiple projections extending from a surface, and at least one of the multiple projections comprises at least one electrode along its length.

64. The system of claim 63, wherein at least one of the multiple projections includes no electrode.

65. The system of claim 63, wherein at least one of the multiple projections includes an anchoring member.

66. The system of claim 59, wherein the sensor further comprises a second multi-electrode array.

67. The system of claim 1, wherein the sensor comprises multiple wires or wire bundle electrodes.

68. The system of claim 1, wherein the plurality of electrodes of the sensor are incorporated into one or more of:

a subdural grid, a scalp electrode, a wire electrode, and a cuff electrode.

69. The system of claim 1, wherein the electrodes comprise wires, and the sensor comprises a wire bundle.

70. The system of claim 1, wherein the sensor comprises two or more discrete components.

71. The system of claim 70, wherein each of the discrete components comprises one or more electrodes.

72. The system of claim 70, wherein each of the discrete components comprises one or more of:

a multi-electrode array;

a wire or wire bundle;

a subdural grid; and

a scalp electrode.

73. The system of claim 1, wherein the electrodes are configured to detect multicellular signals for less than twenty-four hours.

74. The system of claim 1, wherein the electrodes are configured to chronically detect multicellular signals.

75. The system of claim 1, wherein the sensor further comprises a signal processing circuitry.

76. The system of claim 1, wherein the sensor transmits the multicellular signals through a wireless connection.

77. The system of claim 76, wherein the sensor transmits wirelessly to a receiver mounted on the skull of the patient.

78. The system of claim 1, wherein the sensor further comprises a coil for power transmission to the sensor.

79. The system of claim 1, wherein the plurality of electrodes are configured to record from clusters of neurons and output detected signals, the detected signals comprising multiple neuron signals.

80. The system of claim 79, wherein the detected signals are a measure of the local field potential response from neural activity.

81. The system of claim 79, wherein the multiple neuron signals comprise one or more of:

electrocorticogram signals, local field potentials, electroencephalogram signals, and peripheral nerve signals.

82. The system of claim 1, wherein one or more of the plurality of electrodes is configured to detect a plurality of neuron signals.

83. The system of claim 1, wherein a portion of the processing unit is physically connected to the sensor.

84. The system of claim 1, wherein the processing unit comprises an integrated neuron spike sorting function.

85. The system of claim 84, wherein the neuron spike sorting function classifies spikes with a minimum amplitude threshold.

86. The system of claim 1, wherein the processing unit comprises an element to amplify the multicellular signals.

87. The system of claim 86, wherein the signals are amplified by a gain of at least eighty.

88. The system of claim 1, wherein the processing unit utilizes neural net software routines to map neural signals into the processed signals for control of the controlled device.

89. The system of claim 44, wherein the specific use is determined by the patient attempting an imagined movement or state.

90. The system of claim 1, wherein the processing unit is configured to utilize two or more cellular signals that are mathematically combined to create the processed signals.

91. The system of claim 1, wherein the processing unit is configured to use a cellular signal from a neuron whose signal is separated from other nearby neurons.

92. The system of claim 91, wherein the processing unit is configured to separate signals by one or more spike discrimination methods.

93. The system of claim 92, wherein the spike discrimination method sorts spikes by a minimum amplitude threshold.

94. The system of claim 1, wherein the processing unit is configured to convert an analog signal that represents a cellular signal to a digital signal.

95. The system of claim 94, wherein the processing unit is configured to process a monitored biological signal and produce a second processed signal.

96. The system of claim 95, wherein the second processed signal is used to control the controlled device.

97. The system of claim 95, wherein the second processed signal is used to modify one or more parameters of the system.

98. The system of claim 95, wherein the second processed signal is used to stop control of the controlled device.

99. The system of claim 95, wherein the second processed signal is used to reset the system.

100. The system of claim 94, further comprising a permission routine, wherein the permission routine requires approval of the operator, and wherein one or more integrated parameters of the system are modified.

101. The system of claim 100, wherein the permission routine limits parameter modifications to one or more specific operators.

102. The system of claim 101, wherein the permission routine comprises a list of approved operators.

103. The system of claim 101, wherein permission to modify individual integrated parameters is linked to one or more specific operators.

104. The system of claim 101, wherein a specific operator is permitted to approve modification of a parameter within a range of values.

105. The system of claim 104, wherein the range of values is controlled by a second operator.

106. The system of claim 100, wherein the permission routine comprises multiple levels including permissions for multiple operators.

107. The system of claim 106, wherein a first operator controls a first set of one or more integrated parameters, and a second operator controls a second set of one or more integrated parameters.

108. The system of claim 107, wherein the first set of parameters comprises one or more different parameters than the second set of parameters.

109. The system of claim 100, further comprising an interrogation function which interrogates the system and retrieves information stored therein.

110. The system of claim 109, wherein an analysis is performed on the retrieved information, and an output is produced, the output comprising a recommendation for modifying at least one of the integrated parameters.

111. The system of claim 100, wherein prior to implementing a modification, the permission routine checks one or more of:

username, password, and IP address.

112. The system of claim 100, wherein the permission routine comprises a confirmation of modifications prior to implementing a modification.

113. The system of claim 1, further comprising an adaptive processing routine.

114. The system of claim 113, wherein the adaptive processing routine comprises changing over time the type or combination of types of signals processed.

115. The system of claim 114, wherein the types of signals processed comprise one or more of EEG signals, ECoG signals, LFP signals, and neural spikes.

116. The system of claim 1, further comprising a configuration system for calibrating the multicellular signals.

117. The system of claim 116, wherein the configuration system is configured to be activated by a biological signal.

118. The system of claim 116, wherein the configuration system comprises a set of movements for configuration.

119. The system of claim 116, wherein the configuration system comprises a video monitor.

120. The system of claim 119, wherein the configuration system comprises a set of movements for configuration, and the video monitor is configured to display a selected movement.

121. The system of claim 120, wherein the movements displayed are from the patient'"'"'s perspective.

122. The system of claim 116, wherein the configuration system is configured to correlate the selected movement with a cellular signal obtained from tracking the selected movement.

123. The system of claim 116, wherein the configuration system is configured to correlate an integrated parameter relating to the selected movement with a cellular signal obtained from tracking the selected movement.

124. The system of claim 123, wherein the integrated parameter comprises one or more of a position, a velocity, or an acceleration.

125. The system of claim 119, wherein the configuration system comprises a set of movements for configuration, and the video monitor is configured to display a simulation of a selected movement.

126. The system of claim 125, wherein the simulation of the selected movement is displayed from the patient'"'"'s perspective.

127. The system of claim 1, further comprising a patient feedback module.

128. The system of claim 127, wherein the patient feedback module comprises one or more of:

an audio transducer, a tactile transducer, a visual transducer, a video display, and an olfactory transducer.

129. The system of claim 127, wherein the patient feedback module comprises a stimulator, and one or more neurons are stimulated to cause movement or sensation in a part of the patient'"'"'s body.

130. The system of claim 1, further comprising a drug delivery system, wherein the processing unit transmits a signal to the drug delivery system to deliver a therapeutic agent or drug to at least a portion of the patient'"'"'s body.

131. The system of claim 1, further comprising an embedded identification.

132. The system of claim 131, wherein the embedded identification is used to confirm compatibility of one or more discrete components of the system.

133. A method comprising:

providing a biological interface system for collecting multicellular signals emanating from one or more living cells of a patient and for transmitting processed signals to control a device, the biological interface system comprising;

a sensor comprising a plurality of electrodes configured to detect the multicellular signals; and

a processing unit configured to receive the multicellular signals from the sensor and to process the multicellular signals to produce processed signals;

cutting a hole into the skull of the patient;

inserting the sensor through the hole into a portion of the brain;

creating a recess in the skull;

placing the processing unit in the recess;

detecting the multicellular signals using the sensor;

processing the detected multicellular signals to produce processed signals;

transmitting the processed signals via wireless communication through the scalp.

134. The method of claim 133, wherein the wireless communication comprises infrared communication.

135. The method of claim 133, wherein the processing unit comprises a processing unit first portion placed in the recess of the skull and a processing unit second portion placed above the scalp of the patient, and wherein transmitting the processed signals comprises transmitting the processed signals from the processing unit first portion to the processing unit second portion.

136. The method of claim 135, further comprising transmitting the processed signals from the processing unit second portion to the device to be controlled.

137. The method of claim 136, wherein transmitting the processed signals from the processing unit second portion to the device to be controlled is performed via wireless communication.

138. The method of claim 133, wherein the processing unit comprises a processing unit first portion placed in the recess of the skull and a processing unit second portion placed above the scalp of the patient, and wherein the method further comprises transmitting power from the processing unit second portion to the processing unit first portion.

139. The method of claim 138, wherein each of the processing unit first portion and the processing unit second portion comprises a coil assembly, and wherein transmitting power is achieved by inductive coupling between the coil assembly of the processing unit first portion and the coil assembly of the processing unit second portion.

140. The method of claim 139, wherein the transmitting power comprises supplying a driving signal to the coil assembly of the processing unit second portion to generate an electromagnetic field that, through inductive coupling, generates power in the coil assembly of the processing unit first portion.

141. The method of claim 133, wherein the processing unit comprises a processing unit first portion placed in the recess of the skull and a processing unit second portion placed above the scalp of the patient, and wherein the method further comprises transmitting information from the processing unit second portion to the processing unit first portion.

142. The method of claim 141, wherein each of the processing unit first portion and the processing unit second portion comprises a coil assembly, and wherein transmitting information comprises transmitting information between the coil assembly of the processing unit first portion and the coil assembly of the processing unit second portion.

143. The method of claim 142, wherein the transmitting information comprises modulating waveform with circuitry of the coil assembly of the processing unit second portion to transmit information.

144. The method of claim 143, wherein the transmitting information comprises receiving and decoding the transmitted information by the coil assembly of the processing unit first portion.