Methods and products for producing lattices of EMR-treated islets in tissues, and uses therefor

• US 20060058712A1
• Filed: 04/01/2005
• Published: 03/16/2006
• Est. Priority Date: 12/28/2000
• Status: Abandoned Application

• Current Assignee: Palomar Medical Technologies Incorporated (Hologic Incorporated)
• Original Assignee: Palomar Medical Technologies Incorporated (Hologic Incorporated)
• Inventors: Altshuler, Gregory B., Yaroslavsky, Ilya, Childs, James J., Erofeev, Andrei V., Tabatadze, David, Smirnov, Mikhail Z.
• Application Number:
  US11/098,000
• Publication Number:
  US 20060058712A1
• Time in Patent Office: Days
• US Class Current: 601/15
• CPC Class Codes: A61B 18/203 applying laser energy to the outside of the body
• CPC Class Codes: A61B 2017/00765 Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
• CPC Class Codes: A61B 2018/00005 Cooling or heating of the probe or tissue immediately surrounding the probe
• CPC Class Codes: A61B 2018/00452 Skin
• CPC Class Codes: A61B 2018/0047 Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
• CPC Class Codes: A61B 2018/00476 Hair follicles
• CPC Class Codes: A61B 2018/2023 Self-contained devices, i.e. with power supply in the hand-piece
• CPC Class Codes: A61B 2018/20355 Special scanning path or conditions, e.g. spiral, raster or providing spot overlap
• CPC Class Codes: A61H 2201/10 with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infrared or ultraviolet therapy
• CPC Class Codes: A61H 39/002 Using electric currents electrotherapy A61N1/32
• CPC Class Codes: A61N 1/00 Electrotherapy; Circuits therefor A61N2/00 takes precedence; irradiation apparatus A61N5/00
• CPC Class Codes: A61N 2/00 Magnetotherapy

Abstract

Methods of treatment of tissue with electromagnetic radiation (EMR) to produce lattices of EMR-treated islets in the tissue are disclosed. Also disclosed are devices and systems for producing lattices of EMR-treated islets in tissue, and cosmetic and medical applications of such devices and systems.

Claims

1-132. -132. (canceled)

133. A composition for use in performing a treatment on a target area of a patient'"'"'s skin, comprising a material applicable selectively over portions of the target area of a patient'"'"'s skin, the material including an absorbing exogenous chromophore, wherein application of optical energy on the material selectively heats the portions of the target area.

134. The composition of claim 133, wherein the composition includes a high concentration of the chromophore.

135. The composition of claim 134, wherein the composition creates treatment islets over the entire treatment area due to the high concentration.

136. The composition of claim 133, wherein the chromophore is dispersed within the composition so that only portions of the composition having the chromophore heat up upon the application of the optical energy.

137. The composition of claim 136, wherein the optical energy can be applied to the entire composition, resulting in only the portions of the composition with the chromophore heating up.

138. The composition of claim 133, wherein the optical energy is created by a source selected from a group consisting of a LED, a laser, a diode laser bar, a radiant lamp, a halogen lamp, an incandescent lamp, an arc lamp, and a fluorescent lamp.

139. A composition of claim 133, wherein the chromophore is carbon, a metal, an organic dye, a non-organic pigment, or a fullerene.

140. A composition of claim 133, wherein the composition is printable using a printing head on the patient'"'"'s skin.

141. A composition of claim 143, wherein the printing head is within a hand held device including an optical energy source.

142. A composition of claim 133, wherein the composition is arranged in one or more of dots, lines, or irregular shapes.

143. A composition of claim 133, wherein the composition is a mesh of fibers or threads.

144. A substance for use in performing a treatment on a target area of a patient'"'"'s skin, comprising:

a) a film applicable over the target area of a patient'"'"'s skin; and

b) a composition containing an absorbing exogenous chromophore, the composition being selectively affixed to portions of the film, wherein application of optical energy on the composition selectively heats the portions of the target area adjacent the composition.

145. A substance of claim 144, wherein the optical energy is created by a source selected from a group consisting of a LED, a laser, a diode laser bar, a radiant lamp, a halogen lamp, an incandescent lamp, an arc lamp, and a fluorescent lamp.

146. A substance of claim 144, wherein the chromophore is carbon, a metal, an organic dye, a non-organic pigment, or a fullerene.

147. A substance of claim 144, wherein the film is an optically clear polymer.

148. A substance of claim 144, wherein light exposure causes exothermic reaction between at least two different components of the composition.

149. A kit for use in performing a treatment on a target area of a patient'"'"'s skin, comprising:

a material applicable selectively over portions of the target area of a patient'"'"'s skin, the material including an absorbing exogenous chromophore; and

a light emitting assembly for applying optical energy to the target area of the patient'"'"'s skin,

wherein application of optical energy from the light emitting assembly on the material heats the exogenous chromophores to selectively heat portions of the target area of the patient'"'"'s skin.

150. The kit of claim 149, wherein the optical energy has one or more wavelength bands that match the absorption spectrum of the absorbing exogenous chromophore.

151. The kit of claim 149, wherein the material is a patch for application to the patient'"'"'s skin.

152. The kit of claim 149, wherein the material is a lotion for application to the patient'"'"'s skin.

153. A dermatological device, comprising:

a housing capable of being manually manipulated to position a head portion of the housing in proximity to a person'"'"'s skin, the head portion defining a target treatment area on the person'"'"'s skin when in contact with the person'"'"'s skin; and

a substrate having a plurality of absorbing elements, wherein incident radiation from an energy source heats up the absorbing elements so that the absorbing elements create treatment islets in the stratum corneum of the person'"'"'s skin.

154. The dermatological device of claim 153, wherein the substrate is a mask that blocks incident radiation in areas of the mask without the absorbing elements.

155. The dermatological device of claim 153, wherein the mask is formed on a contact plate.

156. The dermatological device of claim 155, wherein the contact plate is a cooling plate.

157. The dermatological device of claim 155, wherein the contact plate forms the head portion of the housing.

158. The dermatological device of claim 153, wherein the absorbing elements are carbon.

159. The dermatological device of claim 153, wherein the energy source is in the housing.

160. The dermatological device of claim 153, wherein the energy source is a base unit that is separate from the housing.

161. A dermatological delivery device, comprising:

a substrate having a plurality of absorbing elements, wherein incident radiation from an energy source heats up the absorbing elements so that the absorbing elements create treatment islets in the stratum corneum of a person'"'"'s skin; and

a composition contained on at least one side of the substrate, wherein, after removal of the substrate, at least a substantial portion of the composition remains on the person'"'"'s skin.

162. The dermatological delivery device of claim 161, wherein a portion of the composition penetrates the stratum corneum of the person'"'"'s skin upon the creation of the treatment islets.

163-285. -285. (canceled)