Treatment of the autonomic nervous system
First Claim
1. An implantable non-cardiac neuromuscular electrostimulator comprising a pulse generator to provide electrostimulation;
- one or more leads with electrodes; and
a controller which, based upon sensed heart rate parameters, stimulates or withholds electrostimulation from the pulse generation through the one or more leads.
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Accused Products
Abstract
Systems and methods are provided for modulating the autonomic nervous system by the electrical stimulation of the neuro-muscular system of a patient, and include an implantable electrical system for gastrointestinal stimulation which incorporates a heart rate sensor to indicate the neurovegetative patient condition, to initiate and terminate stimulation at specific locations, and an algorithm to automatically control electrical stimulation frequency, interval, amplitude, or a combination of such parameters for adaptive treatment of obesity, anorexia, other eating disorders, diseases related with the so called “metabolic syndrome” (e.g., impaired glucose tolerance and diabetes type 2, GERD, systemic hypertension, early arterovascular degeneration, early senility, and the like), and disorders related to a pathologic inbalance of the autonomic nervous system.
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Citations
27 Claims
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1. An implantable non-cardiac neuromuscular electrostimulator comprising a pulse generator to provide electrostimulation;
- one or more leads with electrodes; and
a controller which, based upon sensed heart rate parameters, stimulates or withholds electrostimulation from the pulse generation through the one or more leads. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- one or more leads with electrodes; and
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10. A implantable gastrointestinal neuromuscular pulse generator system comprising:
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a pulse generator to provide electrostimulation;
one or more leads with electrodes for attachment to gastrointestinal tissue; and
a controller which stimulates or withholds electrostimulation, based upon sensed heart rate parameters, to the gastrointestinal tissue through the one or more leads. - View Dependent Claims (11, 12, 13)
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- 14. A method of treating disorders of the body by gastro-intestinal electrical stimulation based upon regulation of the autonomic nervous system.
- 17. A method of treating disorders by gastrointestinal electrical stimulation based upon regulation of the autonomic nervous system using sensed variability of gastric or intestinal electrograms.
- 20. A method of treating an autonomic nervous system related disorder using electrical stimulation of nerve tissue or muscle tissue by altering parasympathetic activity.
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25. A method of treating obesity by gastro intestinal electrical stimulation based upon the relationship between sensed heart rate variability and sensed gastric rate variability.
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26. A method of electrically stimulating the gastrointestinal tract during a body'"'"'s sleep mode based upon sensed variability of heart rate or gastric rate.
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27. (canceled)
Specification