Surface enhanced raman spectroscopy (SERS) substrates exhibiting uniform high enhancement and stability
First Claim
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1. A method of preparing a substrate for surface enhanced Raman spectroscopy, the method comprising:
- preparing an alloy film, the alloy film including a first metal and a second metal; and
removing most of the second metal, so as to obtain a porous film of the first metal, the porous film of the first metal being the substrate for surface enhanced Raman spectroscopy.
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Abstract
An improved substrate for Raman spectroscopy of an analyte comprises a porous metal film. Enhancement factors and uniformity of the substrate can be enhanced by electrochemical roughening of the film. Improved sensors and spectrometers using such substrates are also described.
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Citations
26 Claims
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1. A method of preparing a substrate for surface enhanced Raman spectroscopy, the method comprising:
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preparing an alloy film, the alloy film including a first metal and a second metal; and
removing most of the second metal, so as to obtain a porous film of the first metal, the porous film of the first metal being the substrate for surface enhanced Raman spectroscopy. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for enhanced detection of an analyte, the method comprising:
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preparing a patterned metal substrate;
electrochemically roughening the patterned metal substrate to form a roughened patterned metal substrate; and
exposing the roughened patterned metal substrate to the analyte, wherein an interaction between the roughened patterned metal substrate and the analyte allows the enhanced detection of the analyte. - View Dependent Claims (11, 12, 13, 14, 15)
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16. A substrate useful for surface enhanced Raman spectroscopy (SERS), the substrate comprising a porous metal film,
the porous metal film having a film thickness between approximately 150 nm and approximately 500 nm, and the substrate having a SERS enhancement factor of at least 107.
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19. An apparatus for detecting an analyte, comprising:
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a substrate;
a radiation source, the radiation source operable to provide incident radiation on the substrate; and
a detector, the detector positioned to receive scattered radiation from the analyte when the analyte is adsorbed on the substrate, the scattered radiation being used to detect the analyte, wherein the substrate comprises a porous metal film, the porous metal film including a metal selected from a group of metals consisting of gold, platinum, and silver. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26)
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Specification