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Fiber-modified adenoviral vectors for enhanced transduction of tumor cells

  • US 20060062764A1
  • Filed: 08/11/2005
  • Published: 03/23/2006
  • Est. Priority Date: 08/25/2004
  • Status: Abandoned Application
First Claim
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1. A method of expressing a heterologous nucleic acid in a primary tumor cell comprising transducing said primary tumor cell with an adenovirus vector comprising a chimeric fiber protein wherein said chimeric fiber protein comprises at least a portion of a Subgroup C adenovirus shaft region and at least a portion of the head region of a Subgroup B adenovirus, wherein the head region binds CD46.

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