Antibodies that immunospecifically bind to TRAIL receptors
First Claim
1. An isolated antibody comprising an amino acid sequence selected from the group consisting of:
- (a) an amino acid sequence that is at least 90% identical to a VH domain of any one of SEQ ID NOS;
42, 44, or 46;
(b) an amino acid sequence that is at least 90% identical to a VL domain of any one of SEQ ID NOS;
43, 45, or 47; and
(c) both (a) and (b);
wherein said antibody immunospecifically binds to TR4.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptors. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TRAIL receptor antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor.
217 Citations
20 Claims
-
1. An isolated antibody comprising an amino acid sequence selected from the group consisting of:
-
(a) an amino acid sequence that is at least 90% identical to a VH domain of any one of SEQ ID NOS;
42, 44, or 46;
(b) an amino acid sequence that is at least 90% identical to a VL domain of any one of SEQ ID NOS;
43, 45, or 47; and
(c) both (a) and (b);
wherein said antibody immunospecifically binds to TR4. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
-
-
19. A hybridoma cell line selected from XF2-1A12, XF2-1G3, XF2-1G5, XF2-2D2, XF2-2H1, XF24C2, XF2-4F7, XF24G8, XF24H5, XF2-4H11, XF2-18A10, XF2-19C10, or XF2-23H7, or the hybridoma cell lines contained in ATCC Deposit Nos. PTA-3149, PTA-2687, PTA-3369, PTA-2730, PTA-2729, PTA-2728, PTA-3368, and PTA-2731.
-
20. An antibody that binds TR4 selected from the group consisting of:
-
(a) the antibody expressed by the 7.1.3 cell line contained in ATCC Deposit No. PTA-3149;
(b) the antibody expressed by the 7.3.1 cell line contained in ATCC Deposit No. PTA-2687;
(c) the antibody expressed by the 7.3.2 cell line contained in ATCC Deposit No. PTA-2687;
(d) the antibody expressed by the 7.3.3 cell line contained in ATCC Deposit No. PTA-3369;
(e) the antibody expressed by the 7.8.1 cell line contained in ATCC Deposit No. PTA-2730;
(f) the antibody expressed by the 7.8.2 cell line contained in ATCC Deposit No. PTA-2730;
(g) the antibody expressed by the 7.8.3 cell line contained in ATCC Deposit No. PTA-2730;
(h) the antibody expressed by the 7.10.1 cell line contained in ATCC Deposit No. PTA-2729;
(i) the antibody expressed by the 7.10.2 cell line contained in ATCC Deposit No. PTA-2729;
(j) the antibody expressed by the 7.10.3 cell line contained in ATCC Deposit No. PTA-2729;
(k) the antibody expressed by the 7.12.1 cell line contained in ATCC Deposit No. PTA-2728;
(l) the antibody expressed by the 7.12.3 cell line contained in ATCC Deposit No. PTA-2728;
(m) the antibody expressed by the 8.3.1 cell line contained in ATCC Deposit No. PTA-2731;
(n) the antibody expressed by the 8.3.2 cell line contained in ATCC Deposit No. PTA-2731;
(o) the antibody expressed by primary hybridoma isolate XF2-1A12;
(p) the antibody expressed by primary hybridoma isolate XF2-1G3;
(q) the antibody expressed by primary hybridoma isolate XF2-1G5;
(r) the antibody expressed by primary hybridoma isolate XF2-2D2;
(s) the antibody expressed by primary hybridoma isolate XF2-2H1;
(t) the antibody expressed by primary hybridoma isolate XF2-4C2;
(u) the antibody expressed by primary hybridoma isolate XF2-4F7;
(v) the antibody expressed by primary hybridoma isolate XF24G8;
(w) the antibody expressed by primary hybridoma isolate XF24H5;
(x) the antibody expressed by primary hybridoma isolate XF24H11;
(y) the antibody expressed by primary hybridoma isolate XF2-18A10;
(z) the antibody expressed by primary hybridoma isolate XF2-19C10; and
(aa) the antibody expressed by primary hybridoma isolate XF2-23H7.
-
Specification