Metallic structures incorporating bioactive materials and methods for creating the same
First Claim
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1. A method comprising:
- creating a template on the surface of a substrate;
providing a solution comprising metal ions;
contacting said substrate with said solution;
forming a composite structure on portions of said substrate not covered by said template using an electrochemical process;
removing said template from said substrate after said formation of said composite structure thus leaving pores in said structure; and
loading at least one bioactive material into said pores thus forming a bioactive composite structure over said substrate.
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Abstract
Disclosed herein are methods to create medical devices and medical devices including bioactive composite structures. The methods include using template-assisted electro- or electroless deposition or codeposition methods for providing implantable medical devices coated with bioactive composite structures and also include layering deposited or codeposited metal layers with layers of bioactive materials. In one use, the implantable medical devices of the present invention include stents with bioactive composite structure coatings.
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Citations
20 Claims
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1. A method comprising:
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creating a template on the surface of a substrate;
providing a solution comprising metal ions;
contacting said substrate with said solution;
forming a composite structure on portions of said substrate not covered by said template using an electrochemical process;
removing said template from said substrate after said formation of said composite structure thus leaving pores in said structure; and
loading at least one bioactive material into said pores thus forming a bioactive composite structure over said substrate. - View Dependent Claims (2, 3, 4, 5)
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6. A medical device comprising a bioactive composite structure wherein said bioactive composite structure is formed by:
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creating a template on the surface of a substrate;
providing a solution comprising metal ions;
contacting said substrate and said solution;
forming a composite structure on portions of said substrate not covered by said template using an electrochemical process;
removing said template from said substrate after said formation of said composite structure thus leaving pores in said structure; and
loading at least one bioactive material into said pores thus forming a bioactive composite structure over said substrate. - View Dependent Claims (7, 8, 9)
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10. A stent comprising a bioactive composite structure wherein said bioactive composite structure comprises pores, metal material around said pores and at least one bioactive material within said pores and said metal material.
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11. A method comprising:
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providing a first solution comprising metal ions;
contacting a substrate with said first solution;
forming a first metal layer on said substrate using an electrochemical process;
applying at least one bioactive material to said first metal layer;
contacting said substrate with said first solution or a second solution;
forming a second layer metal layer on said substrate using an electrochemical process. - View Dependent Claims (12, 13, 14, 15)
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16. A medical device comprising a bioactive composite structure wherein said bioactive composite structure is formed by:
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providing a first solution comprising metal ions;
contacting a substrate with said first solution;
forming a first metal layer on said substrate using an electrochemical process;
applying at least one bioactive material to said first metal layer;
contacting said substrate with said first solution or a second solution;
forming a second layer metal layer on said substrate using an electrochemical process. - View Dependent Claims (17, 18, 19)
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20. A stent comprising a bioactive composite structure wherein said bioactive composite structure comprises alternating layers of metal and bioactive materials and wherein said alternating layers are formed by:
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providing a first solution comprising metal ions;
contacting a substrate with said first solution;
forming a first metal layer on said substrate using an electrochemical process;
drying said substrate after said contacting with said solution;
applying at least one bioactive material to said first metal layer;
drying said substrate after said applying;
contacting said substrate with a second solution;
forming a second layer metal layer on said substrate using an electrochemical process.
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Specification