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Modulation of XBP-1 activity for treatment of metabolic disorders

  • US 20060063187A1
  • Filed: 09/15/2005
  • Published: 03/23/2006
  • Est. Priority Date: 09/15/2004
  • Status: Abandoned Application
First Claim
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1. A method of identifying a compound useful in treating at least one symptom of a metabolic disorder comprising:

  • a) providing an indicator composition comprising mammalian XBP-1;

    b) contacting the indicator composition with each member of a library of test compounds;

    c) selecting from the library of test compounds a compound of interest that increases the expression, activity, and/or stability of spliced XBP-1 to thereby identify a compound useful in treating at least one symptom of a metabolic disorder.

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