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Enzymatic activities in chemokine-mediated inflammation

  • US 20060063223A1
  • Filed: 08/04/2005
  • Published: 03/23/2006
  • Est. Priority Date: 08/04/2004
  • Status: Active Grant
First Claim
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1. A method for identifying an inhibitor of CCR1 activity, comprising:

  • (a) contacting protease with a chemokine substrate in the presence of a test compound;

    (b) determining the activity of the protease in the presence of the test compound;

    (c) comparing the activity of the protease in the presence of the test compound with the activity of the protease in the absence of the test compound;

    (d) identifying the test compound as a potential inhibitor of CCR1 activity if the activity of the protease is inhibited in the presence of the test compound.

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