Combination treatment for impaired motor function in parkinson's disease
First Claim
1. A method of treating or improving the clinical status of a patient suffering from undesired motor movement symptoms associated with one or more of Parkinson'"'"'s disease, anti-Parkinson'"'"'s disease drug therapy, and dementia associated with Parkinson'"'"'s disease, by reducing the occurrence, frequency or severity of the one or more motor movement symptoms or by substantially eliminating the occurrence of the one or more motor movement symptoms, the method comprising the steps of:
- a. administering an amount of NMDA-RA to a subject suffering from one or more motor movement symptoms associated with one or more disorders; and
b. administering to the subject an amount of neuroactive agent selected from the group consisting of a selective serotonin reuptake inhibitor, a serotonin norepinephrine reuptake inhibitor, and an anxiolytic agent;
c. wherein the drugs are administered for a period of time sufficient to reduce the occurrence, frequency or severity of the one or more motor movement symptoms or to substantially eliminate the occurrence of the one or more motor movement symptoms.
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Accused Products
Abstract
The invention provides a method, and dosage form therefor, of treating impaired motor function associated with Parkinson'"'"'s disease, anti-Parkinson'"'"'s drug treatment, e.g. L-Dopa therapy, and/or dementia associated with Parkinson'"'"'s disease. The invention includes the combined administration of an NMDA receptor antagonist and an antidepressant, e.g., the combination of amantadine and citalopram or venlafaxine, or an NMDA receptor antagonist and an anxiolytic agent, e.g., amantadine and buspirone or trazodone, for the amelioration of undesired tremors, akinesia, dyskinesia, or bradykinesia associated with one or more different disorders or diseases. The drugs can be included in a single dosage form. One embodiment includes a combination dosage form containing each drug in controlled release forms. Another embodiment includes a combination dosage form providing a controlled release of an NMDA receptor antagonist and a rapid release of a neuroactive agent after administration to a subject.
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Citations
65 Claims
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1. A method of treating or improving the clinical status of a patient suffering from undesired motor movement symptoms associated with one or more of Parkinson'"'"'s disease, anti-Parkinson'"'"'s disease drug therapy, and dementia associated with Parkinson'"'"'s disease, by reducing the occurrence, frequency or severity of the one or more motor movement symptoms or by substantially eliminating the occurrence of the one or more motor movement symptoms, the method comprising the steps of:
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a. administering an amount of NMDA-RA to a subject suffering from one or more motor movement symptoms associated with one or more disorders; and
b. administering to the subject an amount of neuroactive agent selected from the group consisting of a selective serotonin reuptake inhibitor, a serotonin norepinephrine reuptake inhibitor, and an anxiolytic agent;
c. wherein the drugs are administered for a period of time sufficient to reduce the occurrence, frequency or severity of the one or more motor movement symptoms or to substantially eliminate the occurrence of the one or more motor movement symptoms. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A method of treating or improving the clinical status of a patient suffering from undesired motor movement symptoms associated with one or more of Parkinson'"'"'s disease, anti-Parkinson'"'"'s disease drug therapy, and dementia associated with Parkinson'"'"'s disease, the method comprising the steps of:
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a. orally administering an amount of NMDA-RA to a subject suffering from one or more motor movement symptoms associated with one or more disorders; and
b. orally administering to the subject an amount of neuroactive agent selected from the group consisting of a selective serotonin reuptake inhibitor, a serotonin norepinephrine reuptake inhibitor, and an anxiolytic agent;
whereinc. the NMDA-RA and neuroactive agent are administered in a combined amount effective to and for a period of time sufficient to reduce the occurrence, frequency or severity of the one or more motor movement symptoms or to substantially eliminate the occurrence of the one or more motor movement symptoms;
d. the motor movement disorder is selected from the group consisting of tremor, dyskinesia, akinesia, rigidity and bradykinesia. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
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48. A method of improving the clinical status of a subject suffering from undesired motor movement symptoms associated with one or more of Parkinson'"'"'s disease, anti-Parkinson'"'"'s disease drug therapy, and dementia associated with Parkinson'"'"'s disease, the method comprising the step of:
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a. orally administering to the subject on a once or twice daily basis an oral dosage form comprising a therapeutically effective or sub-therapeutically effective amount of an NMDA-RA;
a therapeutically effective or sub-therapeutically effective amount of a neuroactive agent selected from the group consisting of a selective serotonin reuptake inhibitor, a serotonin norepinephrine reuptake inhibitor, and an anxiolytic agent; and
one or more pharmaceutically acceptable excipients;
b. wherein, when the dosage form is administered to the subject, the NMDA-RA is released according to an immediate, rapid, controlled or sustained release profile, the neuroactive agent is released according to an immediate, rapid, controlled or sustained release profile, and release of one or both the NMDA-RA and the neuroactive agent is optionally delayed a lag period, c. whereby the occurrence, frequency or severity of the one or more motor movement symptoms is reduced or substantially eliminated. - View Dependent Claims (49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65)
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Specification