Silicone hydrogel contact lens

• US 20060063852A1
• Filed: 08/26/2005
• Published: 03/23/2006
• Est. Priority Date: 08/27/2004
• Status: Abandoned Application

• Current Assignee: Coopervision International Limited (The Cooper Cos., Inc.)
• Original Assignee: AsahiKasei Aime Co. Ltd. (Asahi Kasei Corporation), CooperVision Incorporated (The Cooper Cos., Inc.)
• Inventors: Back, Arthur, Ikawa, Seiichirou, Iwata, Junichi, Hoki, Tsuneo
• Application Number:
  US11/213,437
• Publication Number:
  US 20060063852A1
• Time in Patent Office: Days
• US Class Current: 523/106
• CPC Class Codes: C08L 51/085 on to polysiloxanes
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

Ophthalmically compatible contact lenses include lens bodies configured for placement on a cornea of an animal or human eye. The lens bodies are made of a hydrophilic silicon-containing polymeric material. The lens bodies have oxygen permeabilities, water content, surface wettabilities, flexibilities, and/or designs to be worn by a lens wearer even during sleep. The present lenses can be worn on a daily basis, including overnight, or can be worn for several days, such as about thirty days, without requiring removal or cleaning.

Claims

1. A silicone hydrogel contact lens, comprising a non-surface treated lens body comprising a hydrophilic, silicon-containing polymeric material, the lens body having at least one of an oxygen permeability, a water content, a surface wettability, a modulus, and a design effective in facilitating ophthalmically compatible wearing of the contact lens by a lens wearer at least for one day.

2. The contact lens of claim 1, wherein the lens body has an oxygen permeability, a water content, a surface wettability, a modulus, and a design effective in facilitating ophthalmically compatible wearing of the contact lens by the lens wearer at least for one day.

3. The contact lens of claim 1, wherein the lens body has an oxygen permeability, a water content, a surface wettability, a modulus, and a design effective in facilitating ophthalmically compatible wearing of the contact lens by the lens wearer for about thirty days.

4. The contact lens of claim 1, wherein the polymeric material comprises units from one silicon-containing macromer.

5. The contact lens of claim 1, wherein the polymeric material comprises units from two different silicon-containing macromers, each macromer having a different molecular weight.

6. The contact lens of claim 1, wherein the lens body has an oxygen permeability of at least about 70 barrers, a water content of at least about 30% by weight, a modulus less than about 1.4 mPa, and a contact angle on a surface of the lens body less than about 60 degrees.

7. The contact lens of claim 6, wherein the lens body has an oxygen permeability greater than about 110 barrers.

8. The contact lens of claim 6, wherein the lens body has a water content greater than about 45% by weight.

9. The contact lens of claim 6, wherein the lens body has a modulus less than about 0.9 mPa.

10. The contact lens of claim 6, wherein the lens body has an oxygen permeability of at least about 115 barrers, a water content of about 48% by weight, and a modulus of about 0.84 mPa.

11. The contact lens of claim 6, wherein the lens body has an oxygen permeability from about 70 barrers to about 100 barrers, a water content of at least about 50% by weight, and a modulus from about 0.3 mPa to about 0.5 mPa.

13. The contact lens of claim 1 wherein the lens body has a Dk of at least about 150 barrers.

12. A contact lens comprising a lens body comprising a hydrophilic, silicon-containing polymeric material, the lens body having a Dk of greater than about 110 barrers and an equilibrium water content of greater than about 30% by weight, the contact lens being ophthalmically compatible.

14. The contact lens of claim 12, wherein the lens body has an equilibrium water content of at least about 35% by weight.

15. The contact lens of claim 12, wherein the lens body has an anterior surface and a posterior surface, and at least one of the anterior and posterior surfaces is not modified.

16. The contact lens of claim 15, wherein both the anterior and posterior surfaces are not modified.

17. The contact lens of claim 12, wherein the lens body has a modulus of about 1.4 mPa or less.

18. The contact lens of claim 12, wherein the lens body has an elongation of at least about 90%.

19. The contact lens of claim 12, wherein the lens body has an ionoflux of no greater than about 5 10⁻

3 mm²/min.

20. The contact lens of claim 12, wherein the polymeric material comprises units from one silicon-containing macromer.

21. The contact lens of claim 12, wherein the polymeric material comprises units from two silicon-containing macromers having different molecular weights.

22. The contact lens of claim 21, wherein units from a high molecular weight silicon-containing macromer are present in a greater amount by weight in the polymeric material than units from a low molecular weight silicon-containing macromer.

23. The contact lens of claim 21, wherein the polymeric material comprises units from a silicon-containing macromer having a number average molecular weight of at least about 10,000.

24. The contact lens of claim 21 wherein the two silicon-containing macromers have number average molecular weights which differ by at least about 5,000.

25. The contact lens of claim 22, wherein units from the high molecular weight silicon-containing macromer are at least about 40% by weight of the polymeric material.

26. The contact lens of claim 22, wherein units from the high molecular weight silicon-containing macromer and from the low molecular weight silicon-containing macromer total at least about 50% by weight of the polymeric material.

27. The contact lens of claim 21, wherein one of the silicon-containing macromers is mono-functional.

28. The contact lens of claim 21, wherein the polymeric material comprise units from a plurality of hydrophilic monomers.

29. A contact lens comprising a lens body comprising a hydrophilic, silicon-containing polymeric material, the lens body having a Dk of greater than about 70 barrers and an equilibrium water content of greater than about 30% by weight, the lens body being produced without surface treatment, the contact lens being ophthalmically compatible.

30. The contact lens of claim 29, wherein the lens body has a Dk of at least about 90 barrers.

31. The contact lens of claim 29, wherein the lens body has an equilibrium water content of at least about 35% by weight.

32. The contact lens of claim 29, wherein the lens body has a modulus of about 1.4 mPa or less.

33. The contact lens of claim 29, wherein the lens body has an elongation of at least about 90%.

34. The contact lens of claim 29, wherein the lens body has an ionoflux of no greater than about 5 10⁻

3 mm²/min.

35. The contact lens of claim 29, wherein the polymeric material comprises units from one silicon-containing macromer.

36. The contact lens of claim 29, wherein the polymeric material comprise units from two silicon-containing macromers having different molecular weights.

37. The contact lens of claim 36, wherein the polymeric material comprises units from a plurality of hydrophilic monomers.

38. A contact lens comprising a lens body comprising a hydrophilic, silicon-containing polymeric material, the lens body having a Dk of greater than 100 barrers, an equilibrium water content of greater than about 30% by weight, and an ionoflux no greater than about 5 10⁻

3 mm²/min, the contact lens being ophthalmically compatible.

39. The contact lens of claim 38, wherein the lens body has a Dk of at least about 130 barrers.

40. The contact lens of claim 38, wherein the lens body has an equilibrium water content of at least about 35% by weight.

41. The contact lens of claim 38, wherein the lens body has an anterior surface and a posterior surface, and at least one of the anterior and posterior surfaces is not treated.

42. The contact lens of claim 41, wherein both the anterior and posterior surfaces are not treated.

43. The contact lens of claim 38, wherein the lens body has a modulus of about 1.4 mPa or less.

44. The contact lens of claim 38, wherein the polymeric material comprise units from two silicon-containing macromers having different molecular weights.

45. The contact lens of claim 38, wherein the polymeric material comprises units from a plurality of hydrophilic monomers.

46. A contact lens comprising a lens body comprising a hydrophilic, silicon-containing polymeric material, the lens body having an equilibrium water content of greater than about 15% by weight, the polymeric material comprises units from two silicon-containing macromers having different molecular weights, the lens body being ophthalmically compatible.

47. The contact lens of claim 46, wherein one of the macromers has a number average molecular weight greater than about 10,000.

48. The contact lens of claim 46, wherein the polymeric material comprises units from a plurality of hydrophilic monomers.

49. The contact lens of claim 46, wherein the lens body has a Dk of at least about 70 barrers.

50. The contact lens of claim 46, wherein the lens body has an equilibrium water content of at least about 30% by weight.

51. The contact lens of claim 46, wherein the lens body has an anterior surface and a posterior surface, and at least one of the anterior and posterior surfaces is not treated.

52. The contact lens of claim 46, wherein the lens body comprises no surface treatment.

53. The contact lens of claim 46, wherein the lens body has a modulus of about 1.4 mPa or less.

54. The contact lens of claim 46, wherein the lens body has an ionoflux of no greater than about 5 10⁻

3 mm²/min.

55. The contact lens of claim 46, wherein the lens body has an elongation of at least about 90%.