Ligand
First Claim
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1. A human antibody polypeptide monomer which binds to CD40L (gp39).
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Abstract
The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity.
64 Citations
94 Claims
- 1. A human antibody polypeptide monomer which binds to CD40L (gp39).
- 13. An antigen-binding polypeptide, said polypeptide comprising a single immunoglobulin variable domain which specifically and monovalently binds CD40L.
- 25. An antibody polypeptide monomer which binds to CD40L, wherein said antibody polypeptide comprises a universal framework.
- 35. A dual specific ligand comprising a first immunoglobulin single variable domain having a binding specificity to a first antigen and a second single variable domain having a binding activity to a second antigen, wherein the first antigen is CD40L and binding of the second single variable domain to the second antigen acts to increase the half-life of the ligand in vivo.
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48. The ligand of cliam 35, wherein said second antigen which acts to increase the half-life of the ligand in vivo, is selected from the group consisting of human serum albumin and a transferin receptor.
- 49. A dual specific ligand comprising an anti-human CD40L dAb and an anti-SA dAb.
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72. A dAb monomer specific for CD40L, which monomer has a dissociation constant (Kd) of 1×
- 10−
8 M or less for human CD40L, and a Koff rate constant of 1×
10−
3 s−
1 or less, as determined by surface plasmon resonance. - View Dependent Claims (76, 81, 83, 84, 85, 86)
- 10−
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73. A dAb monomer specific for CD40L with a dissociation constant (Kd) of 1×
- 10−
7 M or less, as determined by surface plasmon resonance. - View Dependent Claims (74, 75, 77, 78, 79, 80, 82)
- 10−
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87. A dual specific ligand comprising
(i) first and second heavy chain single variable domains, or (ii) first and second light chain single variable domains, wherein the first variable domain is an anti-CD40L dAb monomer.
Specification