Method and apparatus for non-invasive measurement of blood analytes with dynamic spectral calibration

• US 20060063991A1
• Filed: 08/09/2004
• Published: 03/23/2006
• Est. Priority Date: 08/09/2004
• Status: Abandoned Application

• Current Assignee: Dejin Yu, Yang Wei
• Original Assignee: Dejin Yu, Yang Wei
• Inventors: Yang, Wei, Yu, Dejin
• Application Number:
  US10/914,761
• Publication Number:
  US 20060063991A1
• Time in Patent Office: Days
• US Class Current: 600/322
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips
• CPC Class Codes: A61B 5/702 Posture restraints
• CPC Class Codes: G01N 21/65 Raman scattering

Abstract

The present invention discloses a method and apparatus and method for achieving non-invasive measurement of analytes from human and animal blood through the skin using Raman lightwave technology. The apparatus includes a confocal signal collection system that effectively reduces the interferences from out-of-focus signals. The apparatus further includes a tissue permeation unit, which controls the amount of blood in the laser tissue interaction region. The change of aggregate spectra with time is used to construct a new series of differenced spectra, from which the spectral effects from surrounding static substances are calibrated out dynamically using the data processing method described.

Claims

1-18. -18. (canceled)

19. An apparatus for non-invasively evaluating the constituents in the blood of a patient comprising:

a light source for generating a probe beam;

illumination optics for focusing the probe beam onto the target tissue;

a detector for measuring the optical response of the target tissue;

collection optics for collecting the optical response from the target and directing the collected optical response to the detector, said collection optics being arranged in a confocal manner.

20. An apparatus as recited in the claim 19, wherein the collection optics includes focusing elements for creating an image of the target tissue in a plane, and further including a confocal hole located in the image plane, said collection optics minimizing the amount of out-of-focus light reaching the detector.

21. An apparatus as recited in claim 20, wherein said light source is a narrowband laser and the collect optical response corresponds to Raman Spectroscopy.

22. An apparatus as recited in claim 21, further including a means for varying the level of blood in the region of the target tissue so that measurements can be made at different blood levels.

23. An apparatus as recited in claim 19, further including a processor for evaluating the constituents in the blood based on the optical response measured by the detector.