Microfluidic analytical system with accessible electrically conductive contact pads

• US 20060065532A1
• Filed: 09/30/2004
• Published: 03/30/2006
• Est. Priority Date: 09/30/2004
• Status: Abandoned Application

• Current Assignee: Lifescan Incorporated (Duv Holding Corporation)
• Original Assignee: Lifescan Incorporated (Duv Holding Corporation)
• Inventors: Stiene, Matthias, McNeilage, Alan, MacLennan, Margaret, Richter, Tanja Alexandra, Rodgers, James Iain, Moffat, James Thomas
• Application Number:
  US10/957,505
• Publication Number:
  US 20060065532A1
• Time in Patent Office: Days
• US Class Current: 204/600
• CPC Class Codes: B01L 2200/0689 Sealing
• CPC Class Codes: B01L 2300/0645 Electrodes
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: G01N 33/48792 Data management, e.g. communication with processing unit for in vivo diagnostics A61B5/0002; transmission systems for measured values G08C

Abstract

A microfluidic analytical system for monitoring an analyte (such as glucose) in a fluid sample (e.g., blood or ISF) includes an analysis module and an electrical device (for example, a meter or power supply). The analysis module includes an insulating substrate and a microchannel(s) within the insulating substrate'"'"'s upper surface. The analysis module also includes a conductive contact pad(s) disposed on the upper surface of the insulating substrate and an electrode(s), with the electrode(s) being disposed over the microchannel. In addition, the analysis module includes an electrically conductive trace(s) that electrically connects the electrode to at least one electrically conductive contact pad. The analysis module also has a laminate layer disposed over the electrode, the electrically conductive trace, the microchannel and a portion of the upper surface of the insulating substrate. The electrically conductive contact pad of the analysis module has an accessible exposed surface for electrical connection to the electrical device.

Claims

1. A microfluidic analytical system for monitoring an analyte in a fluid sample, the microfluidic system comprising:

an analysis module including;

an insulating substrate with an upper surface, the upper surface having at least one microchannel therein;

at least one electrically conductive contact pad disposed on the upper surface of the insulating substrate;

at least one electrode, each of the at least one electrodes disposed over at least one of the microchannels;

at least one electrically conductive trace electrically connected to at least one electrode and at least one electrically conductive contact pad; and

a laminate layer disposed over the at least one electrode, the at least one electrically conductive trace, the at least one microchannel and a portion of the upper surface of the insulating substrate, and

an electrical device,

wherein the at least one electrically conductive contact pad has at least one accessible exposed surface for electrical connection to the electrical device.

2. The microfluidic analytical device of claim 1, wherein the electrical device in includes at least one contact spring with each of the at least one contact springs being adapted for electrically contacting the accessible exposed surface of at least one electrically conductive contact pad.

3. The microfluidic analytical device of claim 1, wherein the upper surface of the insulating substrate includes a recess and the conductive contact pad is disposed within the recess.

4. The microfluidic analytical device of claim 1, wherein the laminate layer is fused with the portion of the upper surface of the insulating substrate such that the at least one microchannel is essentially liquid tight.

5. The microfluidic analytical device of claim 1, wherein the at least one electrode and at least one electrically conductive trace are fused with the upper surface of the insulating substrate such that the at least one microchannel is essentially liquid tight.

6. The microfluidic analytical device of claim 1, wherein the at least one electrically conductive trace and the at least one electrically conductive contact pad are fused together.

7. The microfluidic analytical device of claim 1, wherein the at least one electrically conductive contact pad is disposed at a periphery of the insulating substrate.

8. The microfluidic analytical device of claim 1, wherein the insulating substrate is circular in shape, includes a plurality of microchannels, includes a plurality of electrodes and the electrically conductive contact pads are disposed at the periphery of the insulating substrate.

9. The microfluidic analytical device of claim 1, wherein the laminate layer is a pliable sheet.

10. The microfluidic analytical device of claim 1, wherein at least one of the electrodes, electrically conductive traces and electrically conductive contact pads are formed from a conductive ink.

11. The microfluidic analytical device of claim 10, wherein the conductive ink has a composition that includes:

micronised powder containing platinum and carbon;

poly(bisphenol A-co-epichlorohydrin)-glycidyl end capped polymer; and

a solvent,

and wherein the ratio of micronised powder to poly(bisphenol A-co-epichlorohydrin)-glycidyl end capped polymer is in the range of 3;

1 to 1;

3.