Methods for identifying a peptide that binds a geometrical shape
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Abstract
Provided herein are methods, such as phage display assays, for bioengineering peptides that bind to geometrically and/or atomically structured molecular surfaces such as, for example, flat surfaces, smooth curved surfaces, as well as surfaces with periodic, random, or fractal atomic configurations. Surface-binding peptides are provided that are identified using the phage-display methods. Furthermore, scanning probe microscopy (SPM) substrates, biosensors, biochips, and electrodes are provided that include the surface-binding peptides.
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Citations
30 Claims
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1-24. -24. (canceled)
- 25. A scanning probe microscopy (SPM) substrate, comprising a substrate comprising an SPM material, wherein the substrate has a flat surface comprising an isolated peptide or polypeptide bound thereto.
- 29. A graphite or carbide electrode having a flat surface or a smooth, curved surface, wherein a peptide is specifically bound to the surface.
Specification