Treatment of neurological deficits in the striatum or substanta nigra pars compacta
First Claim
1. A method of treating neurological deficits resulting from injury or disease to the striatum or substanta nigra pars compacta of a human comprising administering GDF5-HR to said striatum or said substanta nigra pars compacta of said human in amounts effective to induce cell populations comprising the capacity to differentiate towards a dopaminergic phenotype to in fact differentiate towards said dopaminergic phenotype.
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Abstract
The present invention is directed to methods of treating neurological deficits resulting from injury or disease to the striatum or substanta nigra pars compacta of a human by administering human recombinant GDF5 to the striatum or substanta nigra pars compacta of a human in amounts effective to induce cell populations having the capacity to differentiate towards a dopaminergic phenotype to in fact differentiate towards a dopaminergic phenotype, and to neurotrophic compositions and matrices suitable for use in such treatments.
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Citations
20 Claims
- 1. A method of treating neurological deficits resulting from injury or disease to the striatum or substanta nigra pars compacta of a human comprising administering GDF5-HR to said striatum or said substanta nigra pars compacta of said human in amounts effective to induce cell populations comprising the capacity to differentiate towards a dopaminergic phenotype to in fact differentiate towards said dopaminergic phenotype.
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15. A neutrophic composition suitable for treating neurological deficits resulting from injury or disease to the striatum or substanta nigra pars compacta of a human, comprising:
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GDF5-HR in amounts effective to induce cell populations comprising the capacity to differentiate towards a dopaminergic phenotype to in fact differentiate towards said dopaminergic phenotype, Sonic Hedgehog;
FGF8; and
a physiologically acceptable carrier. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification