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Methods and compositions involving sortase B

  • US 20060073530A1
  • Filed: 08/15/2002
  • Published: 04/06/2006
  • Est. Priority Date: 08/15/2001
  • Status: Abandoned Application
First Claim
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1. A method for screening for a sortase-transamidase inhibitor comprising:

  • a) incubating at least a first sortase-transamidase and at least a first polypeptide comprising a sorting signal of NPQ/KTN/G, under conditions to allow the first sortase-transamidase to cleave the first polypeptide within the sorting signal;

    b) incubating the first sortase-transamidase or the first polypeptide with a candidate inhibitor; and

    c) assaying for activity of the first sortase-transamidase, wherein a reduction in activity identifies the compound as a sortase-transamidase inhibitor.

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