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Natriuretic compounds, conjugates, and uses thereof

  • US 20060074009A1
  • Filed: 05/26/2005
  • Published: 04/06/2006
  • Est. Priority Date: 05/26/2004
  • Status: Abandoned Application
First Claim
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1. A natriuretic compound conjugate comprising:

  • a biologically active natriuretic compound comprising;

    a natriuretic molecule NPR-A binding site; and

    at least one modifying moiety conjugation site; and

    at least one modifying moiety attached to said modifying moiety conjugation site;

    wherein said natriuretic compound conjugate exhibits one or more advantages selected from the group consisting of increased resistance to enzymatic degradation relative to a corresponding unconjugated natriuretic compound, increased circulating half life, increased bioavailability, and prolonged duration of effect.

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