Pyridines

• US 20060074237A1
• Filed: 09/29/2005
• Published: 04/06/2006
• Est. Priority Date: 10/04/2004
• Status: Active Grant

• Current Assignee: Hoffmann-La Roche Incorporated (Roche Holding AG)
• Original Assignee: Hoffmann-La Roche Incorporated (Roche Holding AG)
• Inventors: Kuhn, Bernd, Neidhart, Werner, Hunziker, Daniel, Amrein, Kurt, Mayweg, Alexander
• Granted Patent: US 7,482,341 B2
• Time in Patent Office: Days
• US Class Current: 544/60
• CPC Class Codes: A61P 1/14 Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: C07D 213/76 to which a second hetero atom is attached nitro radicals C07D213/61
• CPC Class Codes: C07D 401/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 413/04 directly linked by a ring-member-to-ring-member bond

Abstract

Compounds of formula
as well as pharmaceutically acceptable salts and esters thereof, wherein R¹ to R⁶ have the significance given in claim 1 can be used in the form of pharmaceutical compositions.

Claims

1. A compound of the formula (I):

2. The compound according to claim 1, wherein R⁵ is phenyl, naphtyl, piperidyl or 1,2,3,4-tetrahydro-isoquinolinyl optionally substituted with one to three substituents independently selected from alkyl, halogen, alkoxy, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylcarbonyl, aryl, aryloxy and alkylsulfonyl.

3. The compound according to claim 1, wherein R⁵ is phenyl or naphtyl optionally substituted with one to three substituents independently selected from alkyl, halogen, trifluoromethyl, trifluoromethoxy and aryl.

4. The compound according to claim 1, wherein R⁶ is hydrogen.

5. The compound according to claim 1, wherein R¹ is alkyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, aryl, alkoxyalkylaminocarbonylalkyl, cycloalkylalkoxyalkyl, arylalkyloxyalkyl or trifluoroalkoxyalkyl.

6. The compound according to claim 1, wherein R¹ is hydrogen.

7. The compound according to claim 1, wherein R² is hydrogen, cycloalkylalkoxyalkyl, alkoxyalkyl, piperidyl, pyrrolidyl, morpholinyl, thiomorpholinyl, arylalkyl or aryloxy.

8. The compound according to claim 1, wherein R³ is hydrogen.

9. The compound according to claim 1, wherein R⁴ is hydrogen or halogen.

10. The compound according to claim 1, wherein R⁴ is hydrogen.

11. The compound according to claim 1,selected from

3-Chloro-N-(6-ethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

Biphenyl-4-sulfonic acid (6-ethyl-pyridin-2-yl)-amide;

Biphenyl-4-sulfonic acid (6-propyl-pyridin-2-yl)-amide;

3-Chloro-2-methyl-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;

Naphthalene-2-sulfonic acid (6-propyl-pyridin-2-yl)-amide;

3,4-Dichloro-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;

2,5-Difluoro-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;

2,4-Dichloro-6-methyl-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;

5-Chloro-naphthalene-2-sulfonic acid (6-propyl-pyridin-2-yl)-amide;

3,4-Dimethoxy-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;

4,5-Dichloro-2-fluoro-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;

2,4-Dichloro-5-methyl-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;

Piperidine-1-sulfonic acid (6-propyl-pyridin-2-yl)-amide;

3-Chloro-N-(6-isopropyl-pyridin-2-yl)-4-methyl-benzenesulfonamide;

2,5-Difluoro-N-(6-isopropyl-pyridin-2-yl)-benzenesulfonamide;

N-(6-Isopropyl-pyridin-2-yl)-4-(⁴-trifluoromethyl-phenoxy)-benzenesulfonamide;

2,4-Dichloro-N-(6-isopropyl-pyridin-2-yl)-5-methyl-benzenesulfonamide;

N-(6-Isopropyl-pyridin-2-yl)-4-methanesulfonyl-benzenesulfonamide;

N-(6-Isopropyl-pyridin-2-yl)-4-trifluoromethoxy-benzenesulfonamide;

2-(2,2,2-Trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid (6-isopropyl-pyridin-2-yl)-amide;

N-(6-Isopropyl-pyridin-2-yl)-3-(4-trifluoromethyl-phenoxy)-benzenesulfonamide;

Naphthalene-2-sulfonic acid (6-isopropyl-pyridin-2-yl)-amide;

N-(6-Isopropyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;

N-[6-(2-Chloro-phenyl)-pyridin-2-yl)-5-fluoro-2-methyl-benzenesulfonamide;

3-Chloro-N-[6-(2-chloro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;

Biphenyl-4-sulfonic acid [6-(2-chloro-phenyl)-pyridin-2-yl]-amide;

3-Chloro-N-[6-(2,4-difluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;

3-Chloro-N-[6-(3-fluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;

3-Chloro-N-[6-(2,3-difluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;

3-Chloro-N-[6-(2,5-dichloro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;

N-[6-(2,5-Dichloro-phenyl)-pyridin-2-yl]-5-fluoro-2-methyl-benzenesulfonamide;

3-Chloro-N-[6-(3-chloro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;

N-[6-(3-Chloro-phenyl)-pyridin-2-yl]-5-fluoro-2-methyl-benzenesulfonamide;

3-Chloro-N-[6-(2-fluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;

5-Fluoro-N-[6-(2-fluoro-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;

3-Chloro-2-methyl-N-[6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-benzenesulfonamide;

5-Fluoro-2-methyl-N-[6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-benzenesulfonamide;

N-[6-(2-Chloro-phenyl)-pyridin-2-yl]-2,5-difluoro-benzenesulfonamide;

N-[6-(2-Chloro-phenyl)-pyridin-2-yl]-2-trifluoromethyl-benzenesulfonamide;

3-Chloro-N-[6-(2-methoxy-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;

3-Chloro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;

5-Fluoro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;

N-[2,3′

]Bipyridinyl-6-yl-3-chloro-2-methyl-benzenesulfonamide;

2,5-Difluoro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-benzenesulfonamide;

2,4-Dichloro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;

3,4-Dichloro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-benzenesulfonamide;

3-Chloro-N-(6-methoxy-pyridin-2-yl)-2-methyl-benzenesulfonamide;

Biphenyl-4-sulfonic acid (6-methoxy-pyridin-2-yl)-amide;

5-Fluoro-N-(6-methoxy-pyridin-2-yl)-2-methyl-benzenesulfonamide;

Naphthalene-2-sulfonic acid (6-methoxy-pyridin-2-yl)-amide;

3-Chloro-N-(6-ethoxy-pyridin-2-yl)-2-methyl-benzenesulfonamide;

Biphenyl-4-sulfonic acid (6-ethoxy-pyridin-2-yl)-amide;

Naphthalene-2-sulfonic acid (6-ethoxy-pyridin-2-yl)-amide;

3-Chloro-N-(6-ethylsulfanyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

Biphenyl-4-sulfonic acid (6-ethylsulfanyl-pyridin-2-yl)-amide;

Naphthalene-2-sulfonic acid (6-ethylsulfanyl-pyridin-2-yl)-amide;

Naphthalene-2-sulfonic acid (6-ethanesulfonyl-pyridin-2-yl)-amide;

3-Chloro-2-methyl-N-[6-(2-oxo-pentyl)-pyridin-2-yl]-benzenesulfonamide;

2-[6-(Biphenyl-4-sulfonylamino)-pyridin-2-yl]-N,N-diethyl-acetamide;

Biphenyl-4-sulfonic acid [6-(2-morpholin-4-yl-2-oxo-ethyl)-pyridin-2-yl]-amide;

[6-(3-Chloro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-acetic acid methyl ester;

[6-(5-Fluoro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-acetic acid methyl ester;

N,N-Diethyl-2-[6-(4′

-fluoro-biphenyl-4-sulfonylamino)-pyridin-2-yl]-acetamide;

4-Fluoro-biphenyl-4-sulfonic acid [6-(2-morpholin-4-yl-2-oxo-ethyl)-pyridin-2-yl]-amide;

2-[6-(4-Fluoro-biphenyl-4-sulfonylamino)-pyridin-2-yl]-N-(2-methoxy-ethyl)-acetamide;

2-[6-(3-Chloro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-N,N-diethyl-acetamide;

2-[6-(3,4-Dichloro-benzenesulfonylamino)-pyridin-2-yl]-N,N-diethyl-acetamide

2-[6-(3-Chloro-2-methyl-benzenesulfonylamino)-3-methyl-pyridin-2-yl]-N,N-diethyl-acetamide;

2-[6-(3,4-Dichloro-benzenesulfonylamino)-3-methyl-pyridin-2-yl]-N,N-diethyl-acetamide;

3-Chloro-N-(6-hydroxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

3-Chloro-N-(6-methoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

2,5-Difluoro-N-(6-methoxymethyl-pyridin-2-yl)-benzenesulfonamide;

3-Chloro-N-(6-methoxymethyl-pyridin-2-yl)-4-methyl-benzenesulfonamide;

N-(6-Cyclopropylmethoxymethyl-pyridin-2-yl)-2,5-difluoro-benzenesulfonamide;

5-Fluoro-N-(6-methoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

2,5-Difluoro-N-(6-hydroxymethyl-pyridin-2-yl)-benzenesulfonamide;

Acetic acid 6-(2,5-difluoro-benzenesulfonylamino)-pyridin-2-ylmethyl ester;

Naphthalene-2-sulfonic acid (6-hydroxymethyl-pyridin-2-yl)-amide;

3-Chloro-N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-4-methyl-benzenesulfonamide;

N-(6-Cyclopropylmethoxymethyl-pyridin-2-yl)-5-fluoro-2-methyl-benzenesulfonamide;

3-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-4-methyl-benzenesulfonamide;

3-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;

2,5-Difluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;

5-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-2-methyl-benzenesulfonamide;

Piperidine-1-sulfonic acid (6-methoxymethyl-pyridin-2-yl)-amide;

Piperidine-1-sulfonic acid (6-cyclopropylmethoxymethyl-pyridin-2-yl)-amide

3-Chloro-4-methyl-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-benzenesulfonamide;

3-Chloro-2-methyl-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-benzenesulfonamide;

2,5-Difluoro-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-benzenesulfonamide;

5-Fluoro-2-methyl-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-benzenesulfonamide;

3-Chloro-N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

3,4-Dichloro-N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-benzenesulfonamide;

4-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;

N-[6-(4-Fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;

3-Chloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

N-(5-Cyclopropyl-methoxymethyl-pyridin-2-yl)-2,5-difluoro-benzenesulfonamide

4-Chloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-3-methyl-benzenesulfonamide;

N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-5-fluoro-2-methyl-benzenesulfonamide;

Piperidine-1-sulfonic acid (5-cyclopropyl-methoxymethyl-pyridin-2-yl)-amide;

3-Chloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2,5-difluoro-benzenesulfonamide;

N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-5-fluoro-2-methyl-benzenesulfonamide;

N-(5-Methoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;

3-Chloro-N-(5-methoxymethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

N-[5-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl]-3-trifluoromethylbenzenesulfonamide;

3-Chloro-N-[5-(4-fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl]-2-methylbenzenesulfonamide;

N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethylbenzenesulfonamide;

3-Chloro-2-methyl-N-{6-(methyl-propyl-amino)-methyl]-pyridin2-yl}-benzenesulfonamide;

5-Fluoro-2-methyl-N-{6-[(methyl-propyl-amino)-methyl]-pyridin-2-yl}-benzenesulfonamide;

3-Chloro-N-(5-ethoxymethyl-6-methyl-pyridin-72-yl)-2-methyl-benzenesulfonamide;

3-Chloro-N-(6-cyclopropyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

Naphthalene-1-sulfonic acid (6-cyclopropyl-pyridin-2-yl)-amide;

4-Chloro-N-(6-cyclopropyl-pyridin-2-yl)-2,5-dimethyl-benzenesulfonamide;

4-Chloro-N-(6-cyclopropyl-pyridin-2-yl)-3-methyl-benzenesulfonamide;

N-(6-Cyclopropyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;

2,4-Dichloro-N-(6-cyclopropyl-pyridin-2-yl)-5-methylbenzenesulfonamide;

Naphthalene-2-sulfonic acid (6-cyclopropyl-pyridin2-yl)-amide;

N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;

N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-3,5-bis-trifluoromethyl-benzenesulfonamide;

4-Chloro-N-(5-ethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;

4-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;

4-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-2,5-dimethyl-benzenesulfonamide;

3-Trifluoromethyl-N-[6-(4-trifluoromethyl-phenoxymethyl)-pyridin-2-yl]-benzenesulfonamide;

N-[5-(2-Fluoro-ethoxymethyl)-6-methyl-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;

3-Chloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-benzenesulfonamide;

2,4-Dichloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-6-methyl-benzenesulfonamide;

N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-4-fluoro-3-trifluoromethyl-benzenesulfonamide;

3-Chloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-benzenesulfonamide;

2,4-Dichloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-6-methyl-benzenesulfonamide;

N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;

2,4-Difluoro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;

3-Chloro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;

2,4-Dichloro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;

2,4-Difluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;

3-Chloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;

2,4-Dichloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;

N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-4-fluoro-3-trifluoromethyl-benzenesulfonamide;

4-Fluoro-N-[6-(3-fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;

4-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;

N-[6-(4-Fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethoxy-benzenesulfonamide;

N-(6-Methoxymethyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;

2,4-Dichloro-N-(6-methoxymethyl-pyridin-2-yl)-6-methyl-benzenesulfonamide;

3-Chloro-N-(6-methoxymethyl-pyridin-2-yl)-benzenesulfonamide;

3-Trifluoromethyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesulfonamide;

2,4-Dichloro-6-methyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesulfonamide;

N-[6-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;

2,4-Dichloro-6-methyl-N-[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide;

3-Chloro-N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide;

N-[6-(2-Cyclopropyl-ethoxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;

N-[6-(2-Cyclopropyl-ethoxymethyl)-pyridin-2-yl]-4-fluoro-3-trifluoromethyl-benzenesulfonamide;

2,4-Dichloro-N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;

2,4-Dichloro-5-methyl-N-[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide;

2-Chloro-N-[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-5-trifluoromethyl-benzenesulfonamide;

2,4-Dichloro-N-[6-(3-chloro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;

N-[6-(3-Chloro-benzyloxymethyl)-pyridin-2-yl]-4-fluoro-3-trifluoromethyl-benzenesulfonamide;

N-[6-(4-Chloro-benzyloxymethyl)-pyridin-2-yl]-4-fluoro-3-trifluoromethyl-benzenesulfonamide;

2,4-Dichloro-N-[6-(4-chloro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;

N-[5-(2,2,2-Trifluoro-ethoxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;

2,4-Dichloro-5-methyl-N-[5-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide;

3-Chloro-2-methyl-N-(3,4,5,6-tetrahydro-2H-[1,3′

]bipyridinyl-6′

-yl)-benzenesulfonamide;

3-Chloro-2-methyl-N-(5-pyrrolidin-1-yl-pyridin-2-yl)-benzenesulfonamide;

3-Chloro-2-methyl-N-(5-morpholin-4-yl-pyridin-2-yl)-benzenesulfonamide;

N-(5-Benzyl-pyridin-2-yl)-3-chloro-2-methyl-benzenesulfonamide;

3-Chloro-2-methyl-N-(5-phenethyl-pyridin-2-yl)-benzenesulfonamide;

3-Chloro-2-methyl-N-(6-methyl-5-phenethyl-pyridin-2-yl)-benzenesulfonamide;

3-Chloro-2-methyl-N-(5-thiomorpholin-4-yl-pyridin-2-yl)-benzenesulfonamide;

2,4-Dichloro-N-{5-[2-(4-chloro-phenyl)-ethyl]-pyridin-2-yl}-6-methyl-benzenesulfonamide;

3-Chloro-N-{5-[2-(4-methoxy-phenyl)-ethyl]-pyridin-2-yl}-2-methyl-benzenesulfonamide;

3-Chloro-N-{5-[2-(3-fluoro-phenyl)-ethyl]-pyridin-2-yl}-2-methyl-benzenesulfonamide;

3-Chloro-2-methyl-N-{5-[2-(2-trifluoromethyl-phenyl)-ethyl]-pyridin-2-yl}-benzenesulfonamide

3-Chloro-N-{5-[2-(4-fluoro-phenyl)-ethyl]-pyridin-2-yl}-2-methyl-benzenesulfonamide;

3-Chloro-2-methyl-N-(5-phenoxy-pyridin-2-yl)-benzenesulfonamide;

3-Chloro-N-[5-(2-chloro-phenoxy)-pyridin-2-yl]-2-methyl-benzenesulfonamide;

3-Chloro-N-[5-(4-fluoro-phenoxy)-pyridin-2-yl]-2-methyl-benzenesulfonamide;

2,4-Dichloro-6-methyl-N-(5-phenoxy-pyridin-2-yl)-benzenesulfonamide;

2,4-Dichloro-N-[5-(2-chloro-phenoxy)-pyridin-2-yl]-6-methyl-benzenesulfonamide;

2,4-Dichloro-N-[5-(4-fluoro-phenoxy)-pyridin-2-yl]-6-methyl-benzenesulfonamide;

3-Chloro-2-methyl-N-[5-(2-quinolin-2-yl-ethyl)-pyridin-2-yl]-benzenesulfonamide;

2,4-Dichloro-6-methyl-N-[5-(2-quinolin-2-yl-ethyl)-pyridin-2-yl]-benzenesulfonamide; and

3-Chloro-2-methyl-N-[5-(2-pyridin-2-yl-ethyl)-pyridin-2-yl]-benzenesulfonamide.

12. The compound according to claim 1, selected from:

3-Chloro-N-(6-ethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

Biphenyl-4-sulfonic acid (6-propyl-pyridin-2-yl)-amide;

3-Chloro-2-methyl-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;

2,4-Dichloro-6-methyl-N-(6-propyl-pyridin-2-yl)-benzenesulfonamide;

5-Chloro-naphthalene-2-sulfonic acid (6-propyl-pyridin-2-yl)-amide;

3-Chloro-N-(6-isopropyl-pyridin-2-yl)-4-methyl-benzenesulfonamide;

N-(6-Isopropyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;

3-Chloro-2-methyl-N-[6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-benzenesulfonamide;

2,5-Difluoro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-benzenesulfonamide;

2,4-Dichloro-N-[6-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;

2-[6-(3-Chloro-2-methyl-benzenesulfonylamino)-pyridin-2-yl]-N,N-diethyl-acetamide;

3-Chloro-N-(6-hydroxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

3-Chloro-N-(6-methoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

3-Chloro-N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

3,4-Dichloro-N-(6-cyclopropylmethoxymethyl-pyridin-2-yl)-benzenesulfonamide;

4-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-benzenesulfonamide;

N-[6-(4-Fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;

3-Chloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

3-Chloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

3-Chloro-N-(5-methoxymethyl-6-methyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

N-(5-Ethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethylbenzenesulfonamide;

3-Chloro-N-(6-cyclopropyl-pyridin-2-yl)-2-methyl-benzenesulfonamide;

Naphthalene-1-sulfonic acid (6-cyclopropyl-pyridin-2-yl)-amide;

4-Chloro-N-(6-cyclopropyl-pyridin-2-yl)-2,5-dimethyl-benzenesulfonamide;

N-(6-Cyclopropyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;

N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;

4-Chloro-N-(5-ethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;

2,4-Dichloro-N-(5-cyclopropylmethoxymethyl-pyridin-2-yl)-6-methyl-benzenesulfonamide;

N-(5-Cyclopropylmethoxymethyl-pyridin-2-yl)-4-fluoro-3-trifluoromethyl-benzenesulfonamide;

2,4-Dichloro-N-(5-cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-6-methyl-benzenesulfonamide;

N-(5-Cyclopropylmethoxymethyl-6-methyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;

2,4-Dichloro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;

4-Fluoro-N-[6-(4-fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide;

N-[6-(4-Fluoro-benzyloxymethyl)-pyridin-2-yl]-3-trifluoromethoxy-benzenesulfonamide;

N-(6-Methoxymethyl-pyridin-2-yl)-3-trifluoromethyl-benzenesulfonamide;

3-Trifluoromethyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesulfonamide;

2,4-Dichloro-6-methyl-N-[6-(3,3,3-trifluoro-propoxymethyl)-pyridin-2-yl]-benzenesulfonamide;

2,4-Dichloro-6-methyl-N-[6-(2,2,2-trifluoro-ethoxymethyl)-pyridin-2-yl]-benzenesulfonamide;

2,4-Dichloro-N-[6-(2-cyclopropyl-ethoxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;

2,4-Dichloro-N-[6-(3-chloro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;

N-[6-(4-Chloro-benzyloxymethyl)-pyridin-2-yl]-4-fluoro-3-trifluoromethyl-benzenesulfonamide;

2,4-Dichloro-N-[6-(4-chloro-benzyloxymethyl)-pyridin-2-yl]-6-methyl-benzenesulfonamide;

3-Chloro-2-methyl-N-(3,4,5,6-tetrahydro-2H-[1,3′

]bipyridinyl-6′

-yl)-benzenesulfonamide;

3-Chloro-2-methyl-N-(5-pyrrolidin-1-yl-pyridin-2-yl)-benzenesulfonamide;

3-Chloro-2-methyl-N-(5-morpholin-4-yl-pyridin-2-yl)-benzenesulfonamide;

N-(5-Benzyl-pyridin-2-yl)-3-chloro-2-methyl-benzenesulfonamide;

3-Chloro-2-methyl-N-(6-methyl-5-phenethyl-pyridin-2-yl)-benzenesulfonamide;

3-Chloro-2-methyl-N-(5-thiomorpholin-4-yl-pyridin-2-yl)-benzenesulfonamide;

2,4-Dichloro-N-{5-[2-(4-chloro-phenyl)-ethyl]-pyridin-2-yl}-6-methyl-benzenesulfonamide;

3-Chloro-N-{5-[2-(3-fluoro-phenyl)-ethyl]-pyridin-2-yl}-2-methyl-benzenesulfonamide;

3-Chloro-N-{5-[2-(4-fluoro-phenyl)-ethyl]-pyridin-2-yl}-2-methyl-benzenesulfonamide;

3-Chloro-2-methyl-N-(5-phenoxy-pyridin-2-yl)-benzenesulfonamide;

3-Chloro-N-[5-(2-chloro-phenoxy)-pyridin-2-yl-2-methyl-benzenesulfonamide;

3-Chloro-N-[5-(4-fluoro-phenoxy)-pyridin-2-yl]-2-methyl-benzenesulfonamide;

2,4-Dichloro-6-methyl-N-(5-phenoxy-pyridin-2-yl)-benzenesulfonamide;

2,4-Dichloro-N-[5-(2-chloro-phenoxy)-pyridin-2-yl]-6-methyl-benzenesulfonamide; and

2,4-Dichloro-N-[5-(4-fluoro-phenoxy)-pyridin-2-yl]-6-methyl-benzenesulfonamide.

13. A process for the preparation of a compound according to claim 1, comprising the steps of:

a) reaction of a compound according to formula (II);

in the presence of a compound according to formula

in order to obtain a compound of the formula

and optionally

b) further reaction in the presence of a compound of the formula R⁶—

X in order to obtain a compound of the formula

wherein R¹to R⁶ are defined as in claim 1 and X is Cl, Br or I.

14. A pharmaceutical composition, comprising a therapeutically effective amount of a compound according to claim 1 and a therapeutically inert carrier.

15. A method for the treatment and prophylaxis of diabetes, obesity, eating disorders, dyslipidemiae and hypertension, comprising the step of administering a therapeutically effective amount of a compound according to claim 1 to a patient in need thereof.

16. The method according to claim 15, wherein said diabetes is Type II diabetes.