Integrated radiation therapy systems and methods for treating a target in a patient

• US 20060074302A1
• Filed: 07/25/2005
• Published: 04/06/2006
• Est. Priority Date: 07/23/2004
• Status: Active Grant

• Current Assignee: Varian Medical Systems Incorporated (Siemens AG)
• Original Assignee: Varian Medical Systems Incorporated (Siemens AG)
• Inventors: Mate, Timothy P., Wright, J. Nelson, Dimmer, Steven C., Meier, Eric, Purdy, Lynn M.
• Granted Patent: US 8,340,742 B2
• Time in Patent Office: Days
• US Class Current: 600/427
• CPC Class Codes: A61N 2005/1051 using an active marker
• CPC Class Codes: A61N 5/1039 using functional images, e.g. PET or MRI
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/107 in real time, i.e. during treatment

Abstract

An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy type to identify the marker that is different than the first energy type.

Claims

1. A method of developing a treatment plan for a radiation therapy program, comprising:

acquiring objective target data related to a parameter of a target in the patient by periodically locating a marker with a localization modality using a non-ionizing energy, wherein the marker is positioned within the patient; and

developing a treatment plan using the objective target data.

2. The method of claim 1, further comprising obtaining images of the target and of the marker using an imaging modality before acquiring the objective target data, wherein the imaging modality is different than the localization modality used to acquire the objective target data.

3. The method of claim 1 wherein (a) the target comprises a lesion, (b) a plurality of markers are implanted relative to the lesion, and (c) the parameter of the target is at least one of the size, shape, rotation, and motion of the lesion, and wherein the method further comprises identifying a change in the parameter of the lesion by periodically locating the plurality of markers using the localization modality and determining changes in the relative distances between the markers.

4. The method of claim 3, further comprising sending a warning message when the change in the parameter of the lesion exceeds a predetermined value.

5. The method of claim 3, further comprising (a) sending a warning message when the change in the parameter of the lesion exceeds a predetermined value, and (b) adapting the treatment plan for treating the lesion based on the change in the parameter of the lesion.

6. The method of claim 1 wherein the physical parameter is a trajectory of the target caused by movement of the target within the patient, and the method further comprises determining the trajectory using the periodic locations of the marker.

7. The method of claim 6, further comprising sending a warning message when the change in the target trajectory exceeds a predetermined value.

8. The method of claim 6, further comprising (a) sending a warning message when the change in the target trajectory exceeds a predetermined value, and (b) adapting the treatment plan for treating the target based on the change in the target trajectory.

9. The method of claim 1, wherein the non-ionizing energy is a magnetic field.

10. The method of claim 1 wherein a tracking system that effectuates the localization modality is located in an assessment area separate from a radiation vault containing a radiation delivery device.

11. The method of claim 1 wherein the tracking system is located in a radiation treatment vault containing a radiation delivery device.

12. A method of developing a treatment plan for radiation therapy, comprising:

periodically locating a marker in a reference frame external to a patient with a localization modality using a non-ionizing energy, wherein the marker is positioned within the patient at a site relative to a target in the patient; and

simulating treatment using the periodic locations of the marker and a predetermined treatment plan.

13. The method of claim 12 wherein (a) the target comprises a lesion, (b) a plurality of markers are implanted relative to the lesion, and (c) the method further comprises determining target data related to a parameter of the target by periodically locating the markers using the non-ionizing energy.

14. The method of claim 13 wherein the parameter is at least one of the size, shape, rotation, and motion of the lesion, and wherein the method further comprises identifying a change in the parameter of the lesion by determining changes in the relative distances between the markers.

15. The method of claim 13, further comprising sending a warning message when the change in the parameter of the lesion exceeds a predetermined value.

16. The method of claim 13, further comprising (a) sending a warning message when the change in the parameter of the lesion exceeds a predetermined value, and (b) adapting the treatment plan for treating the lesion based on the change in the parameter of the lesion.

17. The method of claim 12, further comprising determining target data related to a parameter of the target by periodically locating the marker using the non-ionizing energy, wherein the parameter is a trajectory of the target caused by movement of the target within the patient.

18. The method of claim 17, further comprising sending a warning message when the change in the target trajectory exceeds a predetermined value.

19. The method of claim 17, further comprising (a) sending a warning message when the change in the target trajectory exceeds a predetermined value, and (b) adapting the treatment plan for treating the target based on the change in the target trajectory.

20. A method of developing a treatment plan for radiation therapy, comprising:

periodically locating a plurality of markers in a reference frame external to a patient with a localization modality using a non-ionizing energy, wherein the markers are positioned within the patient relative to a target in the patient;

characterizing a parameter of the target by comparing relative positions between the markers; and

inputting the parameter of the markers in a treatment plan for irradiating the patient with an ionizing radiation beam.

21. The method of claim 20 wherein (a) the target comprises a lesion, (b) a plurality of markers are implanted relative to the lesion, and (c) the parameter of the target is at least one of the size, shape, rotation, and motion of the lesion, and wherein the method further comprises identifying a change in the parameter of the lesion by periodically locating the plurality of markers using the localization modality and determining changes in the relative distances between the markers.

22. The method of claim 21, further comprising sending a warning message when the change in the parameter of the lesion exceeds a predetermined value.

23. The method of claim 21, further comprising (a) sending a warning message when the change in the parameter of the lesion exceeds a predetermined value, and (b) adapting the treatment plan for treating the lesion based on the change in the parameter of the lesion.

24. A method for developing a treatment plan for treating a target within a patient using radiation therapy, comprising:

periodically localizing a marker positioned within the patient with a localization system using non-ionizing energy to determine locations of the marker in a reference frame external to the patient;

determining a parameter of the target within the patient based on the location of the marker in the reference frame; and

inputting the parameter of the target into a treatment plan for irradiating the patient with an ionizing radiation beam.

25. The method of claim 24 wherein (a) the target comprises a lesion, (b) a plurality of markers are implanted relative to the lesion, and (c) the parameter of the target is at least one of the size, shape, rotation, and motion of the lesion, and wherein the method further comprises identifying a change in the parameter of the lesion by periodically locating the plurality of markers using the localization modality and determining changes in the relative distances between the markers.

26. The method of claim 25, further comprising sending a warning message when the change in the parameter of the lesion exceeds a predetermined value.

27. The method of claim 25, further comprising (a) sending a warning message when the change in the parameter of the lesion exceeds a predetermined value, and (b) adapting the treatment plan for treating the lesion based on the change in the parameter of the lesion.

28. The method of claim 24 wherein the physical parameter is a trajectory of the target caused by movement of the target within the patient, and the method further comprises determining the trajectory using the periodic locations of the marker.

29. The method of claim 28, further comprising sending a warning message when the change in the target trajectory exceeds a predetermined value.

30. The method of claim 28, further comprising (a) sending a warning message when the change in the target trajectory exceeds a predetermined value, and (b) adapting the treatment plan for treating the target based on the change in the target trajectory.

31. A method of developing a treatment plan for radiation therapy, comprising:

obtaining images of a target in a patient and of a marker positioned within the patient using an imaging modality;

periodically locating the marker in a reference frame external to the patient using a localization modality different than the imaging modality;

defining a parameter of the target based on the locations of the marker in the reference frame; and

inputting the parameter of the target into a plan for controlling a radiation delivery device.

32. The method of claim 31 wherein the imaging modality uses an ionizing radiation and the localization modality uses a non-ionizing radiation.

33. The method of claim 31 wherein the localization modality comprises a magnetic field.

34. A method for developing a treatment plan for radiation therapy, comprising:

obtaining images of a target in a patient and of a marker positioned within the patient using an imaging modality;

periodically locating the marker in a reference frame external to the patient using a localization modality different than the imaging modality; and

instructing the patient to control a body function based on the locations of the marker.

35. A method for developing a treatment plan for radiation therapy, comprising:

periodically locating a marker positioned within a patient with respect to a reference frame external to the patient using a localization modality; and

training the patient to control a body function based on the periodic locations of the marker in the reference frame.

36. A method of integrating planning and setup procedures in radiation therapy, comprising:

developing a treatment plan for treating a target within the patient by (a) periodically locating a marker positioned within the patient with respect to a reference frame external to the patient using a localization modality and (b) determining target data based on the marker locations;

subsequently determining whether the target is in accordance with the target data by periodically locating the marker on a day that the patient is scheduled to be irradiated using the localization modality; and

positioning the patient in an external reference frame of a radiation delivery device by periodically locating the marker in the external reference frame of the radiation delivery device.