Microfluidic pump and valve structures and fabrication methods
First Claim
1. A microfluidic device, comprising a first rigid plastic substrate having upper and lower surfaces, and a substantially rigid plastic membrane, contacting and joined with the upper surface of the first substrate, and having a relaxed state wherein the plastic membrane lies substantially against the upper surface of the first substrate and an actuated state wherein the membrane is moved away from the upper surface of the first substrate.
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Abstract
Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.
167 Citations
45 Claims
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1. A microfluidic device, comprising
a first rigid plastic substrate having upper and lower surfaces, and a substantially rigid plastic membrane, contacting and joined with the upper surface of the first substrate, and having a relaxed state wherein the plastic membrane lies substantially against the upper surface of the first substrate and an actuated state wherein the membrane is moved away from the upper surface of the first substrate.
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42. A microfluidic device, comprising
a first polystyrene substrate having upper and lower surfaces and microfeatures formed therein, and a polystyrene membrane solvent bonded to the upper surface of the first substrate, and having a relaxed state wherein the polystyrene membrane lies substantially against the upper surface of the first substrate and an actuated state wherein the polystyrene membrane is moved away from the upper surface of the first substrate.
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44. A microfluidic system, comprising
a reservoir of the type capable of storing at least one of a fluid material, a gaseous material, a solid material substantially dissolved in a liquid material, an emulsion material, a slurry material, and a fluid material with particles suspended therein, a reservoir pump chamber coupled to the reservoir and being connected to at least two other pump chambers, and a controller capable of sequentially activating the reservoir pump chamber and the two other pump chambers, whereby a material is drawn into the reservoir pump chamber and then partially drawn into respective ones of the two pump chambers and the partially drawn material in one of the two pump chambers may be subsequently returned to the reservoir pump chamber.
Specification