Fabrication of multi-sensor arrays
First Claim
1. A method of making an analyte sensor apparatus comprising the steps of:
- providing a substrate layer;
forming a plurality of analyte sensing elements on the substrate layer, wherein the analyte sensor elements are adapted to contact and sense analyte;
forming a lid layer upon at least one of the plurality of analyte sensor elements, forming at least one analyte sensor membrane over the lid layer, wherein the permeability of the analyte sensor membrane disposed over the lid layer can be controlled so that;
(a) analyte cannot contact at least one of the plurality of analyte sensor elements at a first time point in the use of the analyte sensor apparatus; and
(b) analyte can contact at least one of the plurality of analyte sensor elements at a second time point in the use of the analyte sensor apparatus; and
forming at least one structure operatively coupled to the analyte sensing apparatus for relaying information to and away from the analyte sensing apparatus, so that an analyte sensor apparatus is made.
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Accused Products
Abstract
The disclosure provides methods for fabricating a long-term analyte sensor for measuring at least one analyte in the body of a user. The analyte sensors made by these methods include a plurality of analyte contacting sensor elements and at least one structure for relaying information to and from the sensor. The analyte sensor so fabricated further includes at least one sensor protection membrane that is controllable in a manner such that sensor elements may be activated (e.g. exposed to the external environment) at different times so as to extend the useful life of the sensor. In illustrative analyte sensors, the analyte is glucose.
97 Citations
25 Claims
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1. A method of making an analyte sensor apparatus comprising the steps of:
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providing a substrate layer;
forming a plurality of analyte sensing elements on the substrate layer, wherein the analyte sensor elements are adapted to contact and sense analyte;
forming a lid layer upon at least one of the plurality of analyte sensor elements, forming at least one analyte sensor membrane over the lid layer, wherein the permeability of the analyte sensor membrane disposed over the lid layer can be controlled so that;
(a) analyte cannot contact at least one of the plurality of analyte sensor elements at a first time point in the use of the analyte sensor apparatus; and
(b) analyte can contact at least one of the plurality of analyte sensor elements at a second time point in the use of the analyte sensor apparatus; and
forming at least one structure operatively coupled to the analyte sensing apparatus for relaying information to and away from the analyte sensing apparatus, so that an analyte sensor apparatus is made. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. The method of 1, wherein the apparatus is made so that at least one of the at least one of the plurality of analyte sensor elements is not disposed in a reservoir or well.
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15. A method of making an analyte sensor apparatus for implantation within a mammal comprising the steps of:
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providing a substrate layer;
forming a plurality of analyte sensing elements on the substrate layer, wherein the analyte sensor elements are adapted to contact and sense analyte;
forming a lid layer upon at least one of the plurality of analyte sensor elements, forming a sealed aperture on the lid layer;
forming at least one analyte sensor membrane disposed upon at least one of the plurality of analyte sensor elements in a manner that can reversibly prevent an analyte from contacting the at least one of the plurality of analyte sensor elements, wherein the permeability of the analyte sensor membrane can be controlled to allow an analyte to contact at least one of the plurality of analyte sensor elements; and
forming at least one structure operatively coupled to the analyte sensing apparatus for relaying information to and away from the analyte sensing apparatus, so that an analyte sensor apparatus is made. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification