Microchannel chip system and detection chip

• US 20060078472A1
• Filed: 09/09/2005
• Published: 04/13/2006
• Est. Priority Date: 09/28/2004
• Status: Abandoned Application

• Current Assignee: Aisin Seiki Co., Ltd. (Aisin Corp.)
• Original Assignee: Aisin Seiki Co., Ltd. (Aisin Corp.)
• Inventors: Momiyama, Masayoshi, Kawano, Takashi, Iwata, Yuji
• Application Number:
  US11/221,944
• Publication Number:
  US 20060078472A1
• Time in Patent Office: Days
• US Class Current: 422/100
• CPC Class Codes: B01F 29/31 the containers being supported by driving means, e.g. by rotating rollers
• CPC Class Codes: B01F 31/10 with a mixing receptacle rotating alternately in opposite directions
• CPC Class Codes: B01F 33/30 Micromixers
• CPC Class Codes: B01L 2200/0668 Trapping microscopic beads
• CPC Class Codes: B01L 2300/0636 Integrated biosensor, microarrays
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2300/0877 Flow chambers
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: B01L 3/502761 specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules investigating characteristics of particles G01N15/00
• CPC Class Codes: G01N 21/6458 Fluorescence microscopy fluorescence microscopes per se G02B21/0076 and G02B21/16

Abstract

A microchannel chip system and a detection chip capable of improving detection precision are provided. The detection chip 1 of the microchannel chip system comprises a carrier retention section 13 capable of retaining a carrier supporting a second chemical substance which generates a signal by reacting with a first chemical substance and a microchannel flow channel 10 provided with a supply flow channel 14 which supplies a liquid material containing the first chemical substance to the carrier retention section 13. A carrier mobilization means (a protrusion 2) is provided for enhancing of the reactivity of the second chemical substance supported in the carrier 9 with the first chemical substance contained in the liquid material by moving the carrier retained in the detection chip 1.

Claims

1. A microchannel chip system comprising a detection chip having a microchannel flow channel which is provided with a carrier retention section capable of retaining a carrier supporting a second chemical substance which generates a signal by reacting with a first chemical substance and a supply flow channel which supplies a liquid material containing the first chemical substance to the carrier retention section, and a carrier mobilization means which enhances the reactivity of the second chemical substance supported on the carrier with the first chemical substance contained in the liquid material by move the carrier retained in the carrier retention section.

2. The microchannel chip system according to claim 1, wherein a signal detection means is provided for detection of the signal generated from the carrier retained in the detection chip based on the above-described reaction.

3. The microchannel chip system according to claim 2, wherein the signal detection means detects an optical signal generated from the carrier retained in the detection chip.

4. The microchannel chip system according to claim 3, wherein the optical signal is a fluorescence signal.

5. The microchannel chip system according to claim 3, wherein a light collection means is provided for light collection of the optical signal.

6. The microchannel chip system according to claim 5, wherein the light collection means is a Fresnel lens provided integrally in the detection chip.

7. The microchannel chip system according to claim 2, wherein the signal detection means detects at least one signal selected from a group consisting of a magnetic signal, an electrical signal, and a thermal signal generated from the carrier retained in the detection chip.

8. The microchannel chip system according to claim 1, wherein the carrier mobilization means is composed of a protrusion provided at the detection chip or a holder holding the detection chip.

9. The microchannel chip system according to claim 1, wherein the carrier mobilization means is provided with an actuator which moves the detection chip or the holder holding the detection chip.

10. The microchannel chip system according to claim 9, wherein the actuator is a motor mechanism.

11. The microchannel chip system according to claim 1, wherein the carrier mobilization means is composed of a liquid means which moves the carrier retained in the carrier retention section of the detection chip with kinetic energy of a liquid.

12. The microchannel chip system according to claim 11, wherein the liquid means is composed of a release flow channel which moves the carrier retained in the carrier retention section by releasing the liquid material into the carrier retention section, capable of retaining the carrier, of the detection chip.

13. The microchannel chip system according to claim 12, wherein the microchannel flow channel comprises an upstream section which is located at the upstream side of the carrier retention section and formed at the lower side from the carrier retention section and a downstream section which is located at the downstream side of the carrier retention section and formed at the upper side from the carrier retention section.

14. The microchannel chip system according to claim 1, wherein a washing treatment means is provided for removal of an unreacted substance after a reaction between the first chemical substance and the second chemical substance is completed.

15. The microchannel chip system according to claim 14, wherein the washing treatment means is to flow the liquid material into the microchannel flow channel.

16. The microchannel chip system according to claim 15, wherein the carrier mobilization means moves the carrier while the washing treatment means is operated.

17. The microchannel chip system according to claim 16, wherein the velocity of the detection chip during operation of the washing treatment means is faster than the velocity of the detection chip during the reaction between the first chemical substance and the second chemical substance.

18. The microchannel chip system according to claim 1, wherein the carrier mobilization means is composed of a magnetic field generating means which moves the carrier retained in the carrier retention section of the detection chip with magnetic energy.

19. The microchannel chip system according to claim 1, wherein the carrier is at least one selected from a group consisting of resin, ceramics, charcoal, clay, cellulose, silica gel, glass, and collagen.

20. A detection chip having a microchannel flow channel which is provided with a carrier retention section capable of retaining a carrier supporting a second chemical substance which generates a signal by reacting with a first chemical substance and a supply flow channel which supplies a liquid material containing the first chemical substance into the carrier retention section, wherein the detection chip is provided with a carrier mobilization means which enhances the reactivity of the second chemical substance supported in the carrier with the first chemical substance contained in the liquid material by moving the carrier retained in the carrier retention section.