Method of prevention and treatment of Atherosclerosis, Peripheral vascular disease, Coronary artery disease, aging and age-related disorders including osteoporosis, arthritis, type 2 diabetes, dementia and Alzheimer's disease
First Claim
1. A method of prevention and treatment of vascular and age-related disorders by synergistic inhibition or reduction of Interleukin-6 inflammation in a human or other animal subject. Inhibition of Interleukin 6 mediated inflammation may be achieved indirectly through regulation of endogenous cholesterol synthesis and isoprenoid depletion or by direct inhibition of the signal transduction pathway including interleukin-6 inhibitor/antibody, interleukin-6 receptor inhibitor/antibody, gp130 protein inhibitor/antibody, tyrosine kinases inhibitors/antibodies, mitogen-activated protein (MAP) kinase inhibitors/antibodies, STAT transcription factors inhibitors/antibodies, altered IL-6, partial peptides of IL-6 or IL-6 receptor, or SOCS (suppressors of cytokine signaling) protein, or a functional fragment thereof. Said method comprises administering, to said subject, any one of the following combinations of components that are inhibitors of interleukin-6 mediated inflammation:
- I. A and B II. A, B, and C III. A and C IV. B and C Wherein A is an inhibitor of cholesterol synthesis and includes one or several Statins and Bisphosphonates selected from the Statin group including of lovastatin, simvastatin, pravastatin, fluvastatin, atorvastatin, rivastatin, red yeast rice, red yeast grain, red yeast powder and other statins or a pharmaceutically acceptable salt thereof and the Bisphosphonate group including of Pamidronate, Etidronate, Clodronate, Alendronate, phosphonic acid derivatives, an ester thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof B is one or several inhibitors or antibodies of the Interleukin-6 (IL-6) signal transduction pathway including interleukin-6 inhibitor or antibody, interleukin-6 receptor inhibitor or antibody, gp130 protein inhibitor or antibody, Janus kinases inhibitors or antibodies, MAP kinase inhibitors/antibodies, STAT transcription factors inhibitors or antibodies, altered IL-6, partial peptides of IL-6 or IL-6 receptor, or SOCS (suppressors of cytokine signaling) protein, or a functional fragment thereof. C. is a cholesterol lowering agent or technique selected from the group including of (i) low cholesterol or low fat diet (ii) sequestrants (cholestyramine, colestipol and dialkylaminoalkyl derivatives of a cross-linked dextran), (iii) nicotinyl alcohol, nicotinic acid or a salt thereof, (iv) PPAR.alpha. agonists such as fenofibric acid derivatives (gemfibrozil, clofibrate, fenofibrate and benzafibrate), (v) inhibitors of cholesterol absorption for example beta-sitosterol and (acyl CoA;
cholesterol acyltransferase) inhibitors for example melinamide and (vi) probucol, an ester thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof. said components being administered simultaneously or separately, in amounts which have the effect of ameliorating the vascular and age-related disorders.
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Abstract
This invention relates to a method for prevention and treatment of Atherosclerosis, Peripheral Vascular Disease, Coronary Artery Disease, and age-related disorders including Osteoporosis, Arthritis, Type II Diabetes, Dementia and Alzheimer'"'"'s disease in a subject comprising administering to said subject a therapeutically effective dosage of each component or combination of statins, bisphosphonates, cholesterol lowering agents or techniques, interleukin-6 inhibitor/antibody, interleukin-6 receptor inhibitor/antibody, gp130 protein inhibitor/antibody, tyrosine kinases inhibitors/antibodies, STAT transcription factors inhibitors/antibodies, altered IL-6, partial peptides of IL-6 or IL-6 receptor, or SOCS (suppressors of cytokine signaling) protein, or a functional fragment thereof, administered separately, in sequence or simultaneously. Inhibition of the signal transduction pathway for Interleukin 6 mediated inflammation is key to the prevention and treatment of atherosclerosis, peripheral vascular disease, coronary artery disease, aging and age-related disorders including osteoporosis, type 2 diabetes, dementia and some forms of arthritis and tumors. Inhibition of Interleukin 6 mediated inflammation may be achieved indirectly through regulation of endogenous cholesterol synthesis and isoprenoid depletion or by direct inhibition of the signal transduction pathway including interleukin-6 inhibitor/antibody, interleukin-6 receptor inhibitor/antibody, gp130 protein inhibitor/antibody, tyrosine kinases inhibitors/antibodies, STAT transcription factors inhibitors/antibodies, altered IL-6, partial peptides of IL-6 or IL-6 receptor, or SOCS (suppressors of cytokine signaling) protein, or a functional fragment thereof. Said method for prevention and treatment of said disorders is based on inhibition of Interleukin-6 inflammation through regulation of cholesterol metabolism, isoprenoid depletion and inhibition of the signal transduction pathway.
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Citations
62 Claims
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1. A method of prevention and treatment of vascular and age-related disorders by synergistic inhibition or reduction of Interleukin-6 inflammation in a human or other animal subject. Inhibition of Interleukin 6 mediated inflammation may be achieved indirectly through regulation of endogenous cholesterol synthesis and isoprenoid depletion or by direct inhibition of the signal transduction pathway including interleukin-6 inhibitor/antibody, interleukin-6 receptor inhibitor/antibody, gp130 protein inhibitor/antibody, tyrosine kinases inhibitors/antibodies, mitogen-activated protein (MAP) kinase inhibitors/antibodies, STAT transcription factors inhibitors/antibodies, altered IL-6, partial peptides of IL-6 or IL-6 receptor, or SOCS (suppressors of cytokine signaling) protein, or a functional fragment thereof. Said method comprises administering, to said subject, any one of the following combinations of components that are inhibitors of interleukin-6 mediated inflammation:
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I. A and B II. A, B, and C III. A and C IV. B and C Wherein A is an inhibitor of cholesterol synthesis and includes one or several Statins and Bisphosphonates selected from the Statin group including of lovastatin, simvastatin, pravastatin, fluvastatin, atorvastatin, rivastatin, red yeast rice, red yeast grain, red yeast powder and other statins or a pharmaceutically acceptable salt thereof and the Bisphosphonate group including of Pamidronate, Etidronate, Clodronate, Alendronate, phosphonic acid derivatives, an ester thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof B is one or several inhibitors or antibodies of the Interleukin-6 (IL-6) signal transduction pathway including interleukin-6 inhibitor or antibody, interleukin-6 receptor inhibitor or antibody, gp130 protein inhibitor or antibody, Janus kinases inhibitors or antibodies, MAP kinase inhibitors/antibodies, STAT transcription factors inhibitors or antibodies, altered IL-6, partial peptides of IL-6 or IL-6 receptor, or SOCS (suppressors of cytokine signaling) protein, or a functional fragment thereof. C. is a cholesterol lowering agent or technique selected from the group including of (i) low cholesterol or low fat diet (ii) sequestrants (cholestyramine, colestipol and dialkylaminoalkyl derivatives of a cross-linked dextran), (iii) nicotinyl alcohol, nicotinic acid or a salt thereof, (iv) PPAR.alpha. agonists such as fenofibric acid derivatives (gemfibrozil, clofibrate, fenofibrate and benzafibrate), (v) inhibitors of cholesterol absorption for example beta-sitosterol and (acyl CoA;
cholesterol acyltransferase) inhibitors for example melinamide and (vi) probucol, an ester thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof.said components being administered simultaneously or separately, in amounts which have the effect of ameliorating the vascular and age-related disorders. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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- 15. A method of prevention and treatment of vascular and age-related disorders by inhibition or reduction of Interleukin-6 inflammation through regulation of cholesterol metabolism and isoprenoid depletion, in a human or other animal subject. Said method comprises administering, to said subject, in amounts which have the effect of ameliorating the vascular and age-related disorders, a HMG-CoA reductase inhibitor selected from the group including of lovastatin, simvastatin, pravastatin, fluvastatin, atorvastatin, rivastatin, red yeast rice, red yeast grain, red yeast powder and other statins or a pharmaceutically acceptable salt thereof.
- 27. A method of prevention and treatment of vascular and age-related disorders by inhibition or reduction of Interleukin-6 inflammation through regulation of cholesterol metabolism and isoprenoid depletion, in a human or other animal subject. Said method comprises administering, to said subject, in amounts which have the effect of ameliorating the vascular and age-related disorders, a bisphosphonate selected from the group including of Pamidronate, Etidronate, Clodronate, Alendronate, phosphonic acid derivatives, an ester thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof.
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39. A method of prevention and treatment of vascular and age-related disorders by inhibition or reduction of Interleukin-6 inflammation through regulation of cholesterol metabolism and isoprenoid depletion, in a human or other animal subject. Said method comprises administering, to said subject, in amounts which have the effect of ameliorating the vascular and age-related disorders, a cholesterol lowering agent or technique selected from the group including of (i) low cholesterol or low fat diet (ii) sequestrants (cholestyramine, colestipol and dialkylaminoalkyl derivatives of a cross-linked dextran), (iii) nicotinyl alcohol, nicotinic acid or a salt thereof, (iv) PPAR.alpha. agonists such as fenofibric acid derivatives (gemfibrozil, clofibrate, fenofibrate and benzafibrate), (v) inhibitors of cholesterol absorption for example beta-sitosterol and (acyl CoA:
- cholesterol acyltransferase) inhibitors for example melinamide and (vi) probucol, an ester thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof.
- View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
- 51. A method of prevention and treatment of vascular and age-related disorders by inhibition or reduction of Interleukin-6 inflammation in a human or other animal subject. Said method comprises administering, to said subject, in amounts which have the effect of ameliorating the vascular and age-related disorders, one or several inhibitors or antibodies of the Interleukin-6 (IL-6) signal transduction pathway including interleukin-6 inhibitor or antibody, interleukin-6 receptor inhibitor or antibody, gp130 protein inhibitor or antibody, Janus kinases inhibitors or antibodies, MAP kinase inhibitors/antibodies, STAT transcription factors inhibitors or antibodies, altered IL-6, partial peptides of IL-6 or IL-6 receptor, or SOCS (suppressors of cytokine signaling) protein, or a functional fragment thereof.
Specification
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- Resources
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Current AssigneeOsemwota Sota Omoigui
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Original AssigneeOsemwota Sota Omoigui
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InventorsOmoigui, Osemwota Sota
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Application NumberUS11/122,030Publication NumberTime in Patent OfficeDaysField of SearchUS Class Current424/78.140CPC Class CodesA61K 2300/00 Mixtures or combinations of...A61K 31/22 of acyclic acids, e.g. prav...A61K 31/366 having six-membered rings, ...A61K 31/40 having five-membered rings ...A61K 31/405 Indole-alkanecarboxylic aci...A61K 31/44 Non condensed pyridines; Hy...A61K 31/663 Compounds having two or mor...A61K 36/064 Saccharomycetales, e.g. bak...A61K 39/395 Antibodies agglutinins A61K...A61K 45/06 Mixtures of active ingredie...
