7,8-Disubstituted pyrazolobenzodiazepines
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Abstract
The present invention provides compounds of formula I
wherein R1, R2, R3, R4, and R5 are described herein. The invention also provides syntheses for preparation of such compounds and pharmaceutical compositions containing them. The invention further provides methods for inhibiting kinases, in particular CDK2, for inhibiting angiogenesis, and for treating cancers, in particular breast, colon, prostate, and lung cancer.
81 Citations
63 Claims
- 1. A compound of formula IV
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53. A method of inhibiting angiogenesis in a patient having a tumor comprising administering a therapeutically effective amount of a compound of formula IV
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54. A method of treating breast cancer in a patient comprising administering a therapeutically effective amount of a compound of formula IV
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55. A method of treating prostate cancer in a patient comprising administering a therapeutically effective amount of a compound of formula IV
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56. A method of treating colon cancer in a patient comprising administering a therapeutically effective amount of a compound of formula IV
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57. A method of treating lung cancer in a patient comprising administering a therapeutically effective amount of a compound of formula IV
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58. A process for preparing a compound of formula IV
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59. A process for preparing a compound of formula IV
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60. A process of preparing a compound of formula IV
- 61. A compound of formula XIV
Specification