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Polymer-based tissue-adhesive form medical use

  • US 20060079599A1
  • Filed: 10/05/2005
  • Published: 04/13/2006
  • Est. Priority Date: 10/07/2004
  • Status: Active Grant
First Claim
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1. A kit comprising:

  • a) a first component comprising;

    a first aqueous solution comprising at least one material selected from the group consisting of at least one linear or branched poly(ether) derivatized with acetoacetate groups;

    at least one polysaccharide derivatized with acetoacetate groups wherein said polysaccharide is other than starch, starch derivatives, cellulose, and cellulose derivatives;

    at least one low molecular weight polyol derivatized with acetoacetate groups wherein said polyol has at least two hydroxy groups and has a molecular weight of less than about 300 Daltons;

    at least one hydrolyzed polyvinyl acetate-methyl acrylate copolymer derivatized with acetoacetate groups;

    at least one monosaccharide derivatized with acetoacetate groups;

    at least one reduced monosaccharide derivatized with acetoacetate groups;

    at least one polyether condensation product derivatized with acetoacetate groups wherein said polyether condensation product is produced by reacting at least one core molecule bearing more than one carboxylic acid group thereon with a sufficient amount of at least one polyether terminated with hydroxy groups to produce an esterified polyether with an average of at least two hydroxy end groups;

    at least one first polyamino compound derivatized with acetoacetamide groups; and

    mixtures thereof;

    said material each having a weight-average molecular weight of less than about 200,000 Daltons, and an equivalent weight per acetoacetate group or acetoacetamide group of about 100 to about 2000 Daltons;

    said first aqueous solution containing at least about 5% by weight of said material; and

    b) a second component comprising;

    at least one of (i) a second aqueous solution of at least one second polyamino compound that may be the same or different from said first polyamino compound;

    (ii) at least one 3-aminopropyltrialkoxysilane, 3-aminopropyldialkoxyalkylsilane or 3-aminopropylmonoalkoxydialkylsilane, neat, or in aqueous solution; and

    (iii) an aqueous solution of said at least one second polyamino compound and at least one 3-aminopropyltrialkoxysilane, 3-aminopropyldialkoxyalkylsilane or 3-aminopropylmonoalkoxydialkylsilane;

    wherein said at least one second polyamino compound has an equivalent weight per amino group of about 100 to about 1,000 Daltons, and said second aqueous solution contains from about 5% to about 50% by weight of said at least one second polyamino compound;

    provided that if said second component is (i), then said kit may further comprise a third component comprising at least one 3-aminopropyltrialkoxysilane, 3-aminopropyldialkoxyalkylsilane or 3-aminopropylmonoalkoxydialkylsilane, neat, or in aqueous solution; and

    (c) optionally, a fourth component comprising an aqueous solution comprising an oxidized polysaccharide containing aldehyde groups, having a weight-average molecular weight of about 1,000 to about 1,000,000 Daltons, said oxidized polysaccharide having an equivalent weight per aldehyde group of about 90 to about 1500 Daltons, said solution containing from about 2% to about 40% by weight of the oxidized polysaccharide.

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