Sensors for detecting substances indicative of stroke, ischemia, or myocardial infarction
First Claim
1. A sensor for insertion within a blood vessel comprising:
- a support structure;
a sensor housing carried by the support structure; and
a sensing surface exposed to the exterior of the housing;
wherein the sensor is configured to detect a concentration of a substance indicative of stroke or the onset of stroke and wherein the sensor housing has a streamlined configuration.
0 Assignments
0 Petitions
Accused Products
Abstract
A sensor is disclosed, for implantation within a blood vessel to monitor a substance in or property of blood. In one embodiment, the sensor detects nitric oxide or a nitric oxide metabolite. In another embodiment, other substances such as glutamate, aspartate, arginine, citrulline, acetylcholine, calcium, potassium, or dopamine are monitored. The sensor may be attached to a support structure such as a stent, guidewire, or catheter. In a further embodiment, a catheter is disclosed that extracts patient fluid to a sensor outside the body for monitoring a substance or property of the patient fluid. Methods are also disclosed.
572 Citations
25 Claims
-
1. A sensor for insertion within a blood vessel comprising:
-
a support structure;
a sensor housing carried by the support structure; and
a sensing surface exposed to the exterior of the housing;
wherein the sensor is configured to detect a concentration of a substance indicative of stroke or the onset of stroke and wherein the sensor housing has a streamlined configuration. - View Dependent Claims (2, 3)
-
-
4. A system for monitoring a substance within bodily fluid, comprising:
-
a catheter, a membrane on the surface of the catheter that allows a substance to diffuse across the membrane, wherein the membrane has a streamlined configuration;
a lumen within the catheter, wherein the lumen is in fluid communication with the membrane;
a sensor in fluid communication with the lumen, wherein the sensor determines the concentration of the substance. - View Dependent Claims (5, 6, 7)
-
-
8. A retrievable sensor, comprising:
-
a support, having a first side for contacting the wall of the vessel and a second side for facing radically inwardly toward the center of the vessel;
a sensor carried by the support and having a sensing surface thereon;
a retrieval means connected to the sensor or the support, wherein the retrieval means is configured to move from a first position to a second position. - View Dependent Claims (9)
-
-
10. A method of assessing cerebral vasculature status in a patient, comprising the steps of:
-
positioning a sensor in communication with a body fluid;
determining a baseline concentration of an indicator of the presence of NO or an NO metabolite;
monitoring changes from the baseline; and
activating a signal in response to a change from the baseline by more than a predetermined limit. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
-
-
21. A sensor for insertion within a blood vessel comprising:
-
a guidewire;
a sensor housing attached to the guidewire; and
a sensing surface exposed to the exterior of the housing;
wherein the sensor is configured to detect a concentration of a substance indicative of stroke or the onset of stroke and wherein the sensing surface has a streamlined configuration. - View Dependent Claims (22, 23, 24, 25)
-
Specification