Systems and methods for making non-invasive physiological assessments by detecting induced acoustic emissions
First Claim
1. A method for assessing a physiological parameter of a target tissue, comprising the steps of:
- (a) applying a pulse of focused ultrasound to a first target tissue site thereby inducing oscillation of said first target tissue site;
(b) measuring a property of an acoustic signal emitted from said oscillating first target tissue site; and
(c) relating the property of the emitted acoustic signal to a physiological tissue property.
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Accused Products
Abstract
Systems and methods for assessing a physiological parameter of a target tissue wherein a pulse of focused ultrasound is applied to a target tissue site thereby inducing oscillation of the target tissue. By these systems and methods, a property of an acoustic signal emitted from the oscillating target tissue is measured and related to a physiological property of the tissue. Specific applications for systems and methods of the present invention include the assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties.
187 Citations
41 Claims
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1. A method for assessing a physiological parameter of a target tissue, comprising the steps of:
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(a) applying a pulse of focused ultrasound to a first target tissue site thereby inducing oscillation of said first target tissue site;
(b) measuring a property of an acoustic signal emitted from said oscillating first target tissue site; and
(c) relating the property of the emitted acoustic signal to a physiological tissue property. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. A method for assessing a physiological property of a target tissue, said method comprising the steps of:
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(a) acquiring data relating to intrinsic tissue oscillations at a target tissue site at multiple time points over the course of at least one cardiac cycle; and
(b) relating said intrinsic tissue oscillation data with a physiological property of said target tissue. - View Dependent Claims (38, 39, 40)
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41. A method for assessing a physiological property of a target tissue, said method comprising the step of combining information from intrinsic tissue displacement and extrinsic induced tissue oscillation or emission.
Specification