System and method for sustained baroreflex stimulation
First Claim
1. A medical device, comprising:
- a baroreflex stimulator to generate a stimulation signal, the stimulation signal being adapted to stimulate a baroreflex; and
a controller to communicate with the baroreflex stimulator and implement a baroreflex stimulation protocol to vary an intensity of the baroreflex stimulation provided by the stimulation signal to abate baroreflex adaptation.
1 Assignment
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Accused Products
Abstract
Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a baroreflex stimulator and a controller. The baroreflex stimulator is adapted to generate a stimulation signal to stimulate a baroreflex. The controller is adapted to communicate with the baroreflex stimulator and implement a baroreflex stimulation protocol to vary an intensity of the baroreflex stimulation provided by the stimulation signal to abate baroreflex adaptation. According to various embodiments, the controller is adapted to implement the baroreflex stimulation protocol to periodically modulate the baroreflex stimulation to produce an effect that mimics an effect of pulsatile pressure. Other aspects are provided herein.
363 Citations
47 Claims
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1. A medical device, comprising:
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a baroreflex stimulator to generate a stimulation signal, the stimulation signal being adapted to stimulate a baroreflex; and
a controller to communicate with the baroreflex stimulator and implement a baroreflex stimulation protocol to vary an intensity of the baroreflex stimulation provided by the stimulation signal to abate baroreflex adaptation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 45)
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23. An implantable medical system, comprising:
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means for generating a baroreflex stimulation signal to stimulate a baroreflex; and
means for abating baroreflex adaptation, including means for changing at least one parameter of the baroreflex stimulation signal such that the baroreflex stimulation ranges within a range from a first baroreflex stimulation level and a second baroreflex stimulation level. - View Dependent Claims (24, 25, 26, 27, 28, 29)
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30. A method, comprising:
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generating a baroreflex stimulation signal to stimulate a baroreflex; and
abating baroreflex adaptation, including changing at least one parameter of the baroreflex stimulation signal such that the baroreflex stimulation ranges within a range from a first baroreflex stimulation level and a second baroreflex stimulation level. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 46, 47)
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Specification