Chemical reaction apparatus

• US 20060083667A1
• Filed: 01/28/2005
• Published: 04/20/2006
• Est. Priority Date: 10/18/2004
• Status: Abandoned Application

• Current Assignee: Hitachi Software Engineering Co., Ltd. (Hitachi, Ltd.)
• Original Assignee: Hitachi Software Engineering Co., Ltd. (Hitachi, Ltd.)
• Inventors: Noda, Hideyuki, Kohara, Yoshinobu
• Application Number:
  US11/044,498
• Publication Number:
  US 20060083667A1
• Time in Patent Office: Days
• US Class Current: 422/209
• CPC Class Codes: B01J 19/0046 Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays synthesis methods per se C40B50/00
• CPC Class Codes: B01J 2219/00421 using centrifugation
• CPC Class Codes: B01J 2219/00585 Parallel processes
• CPC Class Codes: B01J 2219/00596 Solid-phase processes
• CPC Class Codes: B01J 2219/00605 the compounds being directly bound or immobilised to solid supports
• CPC Class Codes: B01J 2219/00612 the surface being inorganic
• CPC Class Codes: B01J 2219/00621 by physical means, e.g. trenches, raised areas
• CPC Class Codes: B01J 2219/00648 by the use of solid beads
• CPC Class Codes: B01J 2219/00657 One-dimensional arrays
• CPC Class Codes: B01J 2219/00722 Nucleotides
• CPC Class Codes: B01L 2300/0636 Integrated biosensor, microarrays
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2400/0409 centrifugal forces
• CPC Class Codes: B01L 3/50273 characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043
• CPC Class Codes: C40B 40/06 Libraries containing nucleotides or polynucleotides, or derivatives thereof
• CPC Class Codes: C40B 60/14 for creating libraries
• CPC Class Codes: G01N 2035/00504 combined with carousels
• CPC Class Codes: G01N 2035/00524 Mixing by agitating sample carrier
• CPC Class Codes: G01N 35/025 having a carousel or turntable for reaction cells or cuvettes

Abstract

There will be provided a chemical reaction device and a chemical reaction apparatus capable of performing transverse liquid movement in a simple structure and at low cost without causing contamination and air bubbles. There will be installed a mechanism for supporting the chemical reaction device in any other position than a center of a turntable which can be rotated, for moving liquid by a centrifugal force due to rotation, and for reversing a direction of the flow path independently of the turntable.

Claims

1. A chemical reaction apparatus, comprising:

a turntable;

a turntable driving unit for rotationally driving said turntable;

a device holding unit provided at a position deviated from a rotating shaft on said turntable, for holding a chemical reaction device having a first liquid reservoir, a second liquid reservoir, and a flow path for connecting said first liquid reservoir to said second liquid reservoir; and

a mechanism for changing a direction of said device holding unit.

2. The chemical reaction apparatus according to claim 1, wherein said mechanism is rotational driving means for rotating said device holing unit.

3. The chemical reaction apparatus according to claim 1, wherein said mechanism has a first gear relatively fixed to the outside of said turntable, and a second gear fixed on said turntable, for meshing with said first gear to rotate said device holding unit.

4. The chemical reaction apparatus according to claim 1, further comprising means for making a distance of said device holing unit relative to a rotating shaft of said turntable variable.

5. The chemical reaction apparatus according to claim 1, wherein a distance between the rotating shaft of said turntable and a center of a flow path of the chemical reaction device held by said device holing unit is 150 mm or less.

6. The chemical reaction apparatus according to claim 1, wherein rotary speed of said turntable is 2 revolutions per second or less.

7. The chemical reaction apparatus according to claim 1, further comprising means for changing an angle between a flow path of the chemical reaction device held by said device holding unit and a straight line for connecting the rotating shaft of said turntable to said device holding unit.

8. The chemical reaction apparatus according to claim 1, further comprising a control unit for controlling said turntable driving unit and said mechanism, wherein said control unit controls said mechanism to reverse a direction of said chemical reaction device every time a preset time period elapses.

9. The chemical reaction apparatus according to claim 1, further comprising a control unit for controlling said turntable driving unit and said mechanism, wherein said control unit controls said mechanism to reverse a direction of said chemical reaction device every time said turntable is rotated a predetermined number of times.

10. The chemical reaction apparatus according to claim 1, further comprising a plurality of device holding units on said turntable.

11. A liquid movement method, comprising:

introducing solution into a first liquid reservoir of a chemical reaction device having said first liquid reservoir, a second liquid reservoir, and a flow path for connecting said first liquid reservoir to said second liquid reservoir;

rotating a turntable in which said chemical reaction device is provided, and moving solution within said first liquid reservoir into said second liquid reservoir through said flow path by a centrifugal force due to rotation of said turntable;

rearranging said chemical reaction device so as to actually reverse the direction of said flow path; and

moving the solution within said second liquid reservoir by passing it through said flow path in the reverse direction by a centrifugal force due to the rotation of said turntable.

12. The liquid movement method according to claim 11, wherein said chemical reaction device is bead array in which granular beads have been arranged on a flow path.

13. The liquid movement method according to claim 11, wherein on a surface of said granular beads, there has been fixed a nucleic probe.

14. The liquid movement method according to claim 11, wherein said chemical reaction device has a reaction portion in which a substance which specifically reacts with a specific substance within a flow path has been fixed.

15. The liquid movement method according to claim 11, wherein rotary speed of said turntable is 2 revolutions per second or less.

16. The liquid movement method according to claim 11, wherein a process of rearranging said chemical reaction device is repeated every time a preset time period elapses.

17. The liquid movement method according to claim 11, wherein a process of rearranging said chemical reaction device is repeated every time said turntable is rotated a predetermined number of times.

18. A chemical reactor, comprising:

a turntable;

a chemical reaction device having a first liquid reservoir, a second liquid reservoir, and a flow path for connecting said first liquid reservoir to second liquid reservoir;

a device holding unit for holding said chemical reaction device at a position deviated from a rotating shaft on said turntable; and

a mechanism for changing a direction of said device holding unit.

19. The chemical reactor according to claim 18, wherein said mechanism is rotational driving means for rotating said device holding unit.

20. The chemical reactor according to claim 18, further comprising means for making a distance of said device holing unit relative to a rotating shaft of said turntable variable.