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Intranasal opioid compositions, delivery devices and methods of using same

  • US 20060083691A1
  • Filed: 10/05/2005
  • Published: 04/20/2006
  • Est. Priority Date: 05/10/2000
  • Status: Abandoned Application
First Claim
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1. A method for providing analgesia to a subject in need thereof, the method comprising intranasally administering to the subject, using an intranasal unit dose delivery device, a pharmaceutical composition comprising:

  • an effective amount of butorphanol or a pharmaceutically acceptable salt thereof, and a liquid nasal carrier, wherein upon intranasal administration of the composition to a subject, the subject exhibits one or more of;

    a Tmax butorphanol plasma concentration of at most about 0.75 hr;

    a Cmax butorphanol plasma concentration of about 1000 pg/ml to about 10,000 pg/ml; and

    /or an AUC butorphanol plasma concentration of about 5000 pg*hr/ml to about 18,000 pg*hr/ml.

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