Coating compositions for bioactive agents
First Claim
1. A composition for coating the surface of a medical device with a bioactive agent in a manner that permits the coated surface to release the bioactive agent over time when implanted in vivo, the composition comprising a bioactive agent in combination with a plurality of polymers, including a first polymer component and a second polymer component, and further comprising a topcoat in apposition to the composition, the topcoat including the polymer of the second polymer component in the composition and a topcoat bioactive agent.
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Accused Products
Abstract
A coating composition and related method for use in applying a bioactive agent to a surface in a manner that will permit the bioactive agent to be released from the coating in vivo. The composition is particularly well suited for coating the surface of implantable medical device, such as a stent or catheter, in order to permit the device to release bioactive agent to the surrounding tissue over time. The composition includes a plurality of compatible polymers having different properties that can permit them to be combined together to provide an optimal combination of such properties as durability, biocompatibility, and release kinetics.
145 Citations
30 Claims
- 1. A composition for coating the surface of a medical device with a bioactive agent in a manner that permits the coated surface to release the bioactive agent over time when implanted in vivo, the composition comprising a bioactive agent in combination with a plurality of polymers, including a first polymer component and a second polymer component, and further comprising a topcoat in apposition to the composition, the topcoat including the polymer of the second polymer component in the composition and a topcoat bioactive agent.
- 7. A composition for coating the surface of a medical device with a bioactive agent in a manner that permits the coated surface to release the bioactive agent over time when implanted in vivo, the composition comprising a bioactive agent in combination with a plurality of polymers, including a first polymer component comprising at least one polymer selected from the group consisting of ethylene copolymers with other alkylenes, polybutenes, aromatic group-containing copolymers, epichlorohydrin-containing polymers, poly(alkylene-co-alkyl(meth)acrylates), and diolefin-derived, non-aromatic polymers and copolymers and a second polymer component comprising a polymer selected from the group consisting of poly(alkyl(meth)acrylates) and poly(aromatic(meth)acrylates), and further comprising a topcoat in apposition to the composition, the topcoat including the polymer of the second polymer component in the composition and a topcoat bioactive agent.
- 10. A composition for coating the surface of a medical device with a bioactive agent in a manner that permits the coated surface to release the bioactive agent over time when implanted in vivo, the composition comprising a bioactive agent in combination with a plurality of polymers, including a first polymer component and a second polymer component, and further comprising a topcoat in apposition to the composition, the topcoat including a topcoat bioactive agent, the topcoat reducing the elution rate of a bioactive agent from a medical device surface.
- 17. A composition for coating the surface of a medical device with a bioactive agent in a manner that permits the coated surface to release the bioactive agent over time when implanted in vivo, the composition comprising a bioactive agent in combination with a plurality of polymers, including a hydrophobic first polymer component and a hydrophobic second polymer component, and further comprising a hydrophilic topcoat.
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21. A method of controlling the elution rate of one or more bioactive agents from a coated surface of a medical device comprising:
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administering a bioactive agent coating including a composition comprising a bioactive agent in combination with a plurality of polymers, including a first polymer component and a second polymer component to a surface; and
administering a topcoat over the bioactive agent coating, the topcoat including one or more bioactive agents. - View Dependent Claims (22, 23, 24, 25)
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- 26. A combination including a medical device and a composition for coating the surface of the medical device with a bioactive agent in a manner that permits the coated surface to release the bioactive agent over time when implanted in vivo, the composition comprising a bioactive agent in combination with a plurality of polymers, including a first polymer component and a second polymer component, the medical device having a roughened surface to increase the adhesion of the coating composition to the medical device and/or alter the elution rate of the bioactive agent.
Specification