Preparations for topical application and methods of delivering an active agent to a substrate
First Claim
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1. A multi-layer dressing for topical application to a substrate, said dressing comprising:
- (A) a controlled-release layer formed from a controlled-release composition comprising;
(i) an oil-in-water or water-in-oil emulsion, and (ii) an active agent incorporated into said emulsion and comprising a protein;
(B) an adhesive layer disposed adjacent said controlled-release layer; and
(C) an additional layer selected from the group of a backing layer, a cushioning layer, an absorbent layer, a second adhesive layer, and combinations thereof, wherein the adhesive layer comprises a silicone adhesive, a non-silicone adhesive, or combinations thereof.
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Abstract
A multi-layer dressing and controlled-release composition for topical application to a substrate include an emulsion and an active agent incorporated into the emulsion. The active agent includes a protein. A method of delivering the active agent to the substrate provides the emulsion and incorporates the active agent into the emulsion for delivery of the active agent to the substrate. Multi-layer dressings and methods particularly suited for management of wound exudate and effective debridement of wound eschar.
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Citations
38 Claims
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1. A multi-layer dressing for topical application to a substrate, said dressing comprising:
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(A) a controlled-release layer formed from a controlled-release composition comprising;
(i) an oil-in-water or water-in-oil emulsion, and (ii) an active agent incorporated into said emulsion and comprising a protein;
(B) an adhesive layer disposed adjacent said controlled-release layer; and
(C) an additional layer selected from the group of a backing layer, a cushioning layer, an absorbent layer, a second adhesive layer, and combinations thereof, wherein the adhesive layer comprises a silicone adhesive, a non-silicone adhesive, or combinations thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A multi-layer dressing for topical application to a substrate, said dressing comprising:
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(A) a controlled-release layer formed from a controlled-release composition comprising;
(i) an oil-in-water or water-in-oil emulsion, and (ii) an active agent incorporated into said emulsion and comprising a protein; and
(B) an adhesive layer disposed adjacent said controlled-release layer;
(C) an occlusive layer disposed adjacent said adhesive layer and away from said controlled release layer;
(E) an absorbent layer disposed opposite the occlusive layer from the controlled release layer; and
,(F) optionally, at least one additional layer selected from the group of a backing layer, a cushioning layer, a second absorbent layer, a second adhesive layer, a porous adhesive layer, and combinations thereof. - View Dependent Claims (12, 13, 14, 15, 16, 17)
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18. A method of managing wound exudates, the method comprising:
- adhering a multilayer dressing to a substrate for an effective amount of time, the multilayer dressing comprising;
(A) a controlled-release layer formed from a controlled-release composition comprising;
(i) an oil-in-water or water-in-oil emulsion, and (ii) an active agent incorporated into said emulsion and comprising a protein; and
(B) an adhesive layer disposed adjacent said controlled-release layer;
(C) an occlusive layer disposed adjacent said adhesive layer and away from said controlled release layer;
(E) an absorbent layer disposed opposite the occlusive layer from the controlled release layer; and
,(F) optionally, at least one additional layer selected from the group of a backing layer, a cushioning layer, a second absorbent layer, a second adhesive layer, a porous adhesive layer, and combinations thereof. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27)
- adhering a multilayer dressing to a substrate for an effective amount of time, the multilayer dressing comprising;
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28. A method of achieving noninvasive debridement of wound eschar, the method comprising:
- adhering a multilayer dressing to a substrate, wherein the multilayer dressing comprises;
(A) a controlled-release layer formed from a controlled-release composition comprising;
(i) an oil-in-water or water-in-oil emulsion, and (ii) an active agent incorporated into said emulsion and comprising a protein; and
(B) an adhesive layer disposed adjacent said controlled-release layer;
(C) an occlusive layer disposed adjacent said adhesive layer and away from said controlled release layer;
(E) an absorbent layer disposed opposite the occlusive layer from the controlled release layer; and
,(F) optionally, at least one additional layer selected from the group of a backing layer, a cushioning layer, a second absorbent layer, a second adhesive layer, a porous adhesive layer, and combinations thereof. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
- adhering a multilayer dressing to a substrate, wherein the multilayer dressing comprises;
Specification