Novel pyrimidine compounds, process for their preparation and compositions containing them

• US 20060084645A1
• Filed: 09/23/2005
• Published: 04/20/2006
• Est. Priority Date: 09/23/2004
• Status: Active Grant

• Current Assignee: Dr. Reddy's Laboratories Ltd.
• Original Assignee: Dr. Reddy's Laboratories Ltd.
• Inventors: Pillarisetti, Sivaram, Iqbal, Javed, Khanna, Ish, Alexander, Christopher W., Swamy, Nalivela Kumara, Barange, Deepak, Kalleda, Srinivas, Padakanti, Srinivas, Yeleswarapu, Koteswar Rao, Pal, Manojit
• Granted Patent: US 7,820,654 B2
• Time in Patent Office: Days
• US Class Current: 514/227.800
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 239/30 Halogen atoms or nitro radicals
• CPC Class Codes: C07D 239/40 as doubly bound sulfur atom or as unsubstituted mercapto radical
• CPC Class Codes: C07D 239/42 One nitrogen atom nitro radicals C07D239/30
• CPC Class Codes: C07D 239/46 Two or more oxygen, sulphur or nitrogen atoms
• CPC Class Codes: C07D 239/47 One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
• CPC Class Codes: C07D 239/48 Two nitrogen atoms
• CPC Class Codes: C07D 239/50 Three nitrogen atoms
• CPC Class Codes: C07D 239/54 as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
• CPC Class Codes: C07D 401/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 403/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 405/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 405/14 containing three or more hetero rings

Abstract

The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

Claims

1. A compound having the formula:

2. A compound according to claim 1, having the formula:

3. A compound according to claim 1, having the formula:

4. A compound according to claim 3, wherein:

R⁴ is selected from

wherein X is selected from CH₂, O, NH, NMe, NEt, S, SO₂, or CH(OH); and

R¹¹ and R¹², in each occurrence, are selected independently from OCF₃, OMe, Cl, F, SO₂Me, CF₃, Me, COMe, SMe, CONHMe, NHSO₂Me, SO₂NH₂, SO₂NHMe, SO₂NMe₂, CONH₂, CONMe₂, CO₂Me, CO₂H, —

OCH₂O —

, or OH.

5. A compound according to claim 1, having the formula:

6. A compound having the formula:

7. A compound according to claim 6, having the formula:

8. A compound according to claim 7, wherein:

R⁴ is selected from

wherein X is selected from CH₂, O, NH, NMe, NEt, S, SO₂, or CH(OH); and

R¹¹, in each occurrence, is selected independently from OCF₃, OMe, Cl, F, SO₂Me, CF₃, Me, COMe, CONHMe, NHSO₂Me, SO₂NH₂, SO₂NHMe, SO₂NMe₂, CONH₂, CONMe₂, CO₂Me, CO₂H, —

OCH₂O —

, or OH.

9. A compound according to claim 6, having the formula:

10. A compound according to claim 6, having the formula:

11. A compounds having the formula:

13. A compound having the formula:

12. A compounds according to claim 13, wherein R² is selected from

14. A compound selected from:

1-[2-(3-Chloro-4-methoxy-phenylamino)-6-cycloheptylamino-pyrimidin-4-yl]-piperidin-4-ol;

N²,N⁴-Bis-(3-chloro-4-methoxy-phenyl)-6-phenyl-pyrimidine-2,4-diamine;

N²-(3-Chloro-4-methoxy-phenyl)-N⁴-methyl-6-phenyl-pyrimidine-2,4-diamine;

N²-(3-Chloro-4-methoxy-phenyl)-N⁴-isopropyl-6-phenyl-pyrimidine-2,4-diamine;

N²-(3-Chloro-4-methoxy-phenyl)-N⁴-cycloheptyl-6-phenyl-pyrimidine-2,4-diamine;

N⁴-Benzyl-N²-(3-chloro-4-methoxy-phenyl)-6-phenyl-pyrimidine-2,4-diamine;

(3-Chloro-4-methoxy-phenyl)-[4-ethoxy-6-(4-methoxy-phenyl)-pyrimidin-2-yl]-amine;

(3-Chloro-4-methoxy-phenyl)-[4-isopropoxy-6-(4-methoxy-phenyl)-pyrimidin-2-yl]-amine;

[4-Benzyloxy-6-(4-methoxy-phenyl)-pyrimidin-2-yl]-(3-chloro-4-methoxy-phenyl)-amine;

(3-Chloro-4-methoxy-phenyl)-[4-(4-methoxy-phenyl)-6-(4-methyl-benzyloxy)-pyrimidin-2-yl]-amine;

[2-(3-Chloro-4-methoxy-phenylamino)-6-(4-methoxy-phenyl)-pyrimidin-4-yloxy]-acetic acid ethyl ester;

[2-(3-Chloro-4-methoxy-phenylamino)-6-(4-methoxy-phenyl)-pyrimidin-4-yloxy]-acetic acid;

1-[4-(3-Chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-2-yl]-piperidin-4-ol;

1-[4-(3-Fluoro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-2-yl]-piperidin-4-ol;

1-[4-(Methyl-phenyl-amino)-6-phenyl-pyrimidin-2-yl]-piperidin-4-ol;

1-[4-Phenyl-6-(3-trifluoromethyl-phenylamino)-pyrimidin-2-yl]-piperidin-4-ol;

1-[4-(4-Chloro-3-trifluoromethyl-phenylamino)-6-phenyl-pyrimidin-2-yl]-piperidin-4-ol;

1-[4-(Benzo[1,3]dioxol-5-ylamino)-6-phenyl-pyrimidin-2-yl]-piperidin-4-ol;

1-[4-Phenyl-6-(4-trifluoromethyl-phenylamino)-pyrimidin-2-yl]-piperidin-4-ol;

(2-Morpholin-4-yl-6-phenyl-pyrimidin-4-yl)-(3-rifluoromethyl-phenyl)-amine;

1-[4-Phenyl-6-(4-trifluoromethoxy-phenylamino)-pyrimidin-2-yl]-piperidin-4-ol;

1-[2-(3-Chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

(4-Morpholin-4-yl-6-phenyl-pyrimidin-2-yl)-(4-trifluoromethoxy-phenyl)-amine;

4-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-N-methyl-benzenesulfonamide;

1-{4-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-phenyl}-ethanone hydro chloride;

1-[2-(3-Chloro-4-hydroxy-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

1-[2-(3-Fluoro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

1-(6-Phenyl-2-phenylamino-pyrimidin-4-yl)-piperidin-4-ol;

(3-Chloro-4-methoxy-phenyl)-(4-phenyl-6-thiomorpholin-4-yl-pyrimidin-2-yl)-amine;

Benzo[1,3]dioxol-5-yl-(4-phenyl-6-thiomorpholin-4-yl-pyrimidin-2-yl)-amine;

(3-Fluoro-4-methoxy-phenyl)-(4-phenyl-6-thiomorpholin-4-yl-pyrimidin-2-yl)-amine;

2-Chloro-4-(4-phenyl-6-thiomorpholin-4-yl-pyrimidin-2-ylamino)-phenol;

(3-Chloro-4-methoxy-phenyl)-(4-morpholin-4-yl-6-phenyl-pyrimidin-2-yl)-amine;

Benzo[1,3]dioxol-5-yl-(4-morpholin-4-yl-6-phenyl-pyrimidin-2-yl)-amine;

(3-Fluoro-4-methoxy-phenyl)-(4-morpholin-4-yl-6-phenyl-pyrimidin-2-yl)-amine;

2-Chloro-4-(4-morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-phenol;

1-[6-Phenyl-2-(3-trifluoromethyl-phenylamino)-pyrimidin-4-yl]-piperidin-4-ol;

Benzo[1,3]dioxol-5-yl-[4-(4-fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-yl]-amine;

1-[2-(Benzo[1,3]dioxol-5-ylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

[4-(4-Fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine;

(4-Fluoro-phenyl)-[4-(4-fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-yl]-amine;

1-[2-(4-Chloro-3-trifluoromethyl-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

(4-Morpholin-4-yl-6-phenyl-pyrimidin-2-yl)-(3-trifluoromethyl-phenyl)-amine;

N-{4-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-phenyl}-methanesulfonamide;

N-[4-(4-Morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-phenyl]-methanesulfonamide hydrochloride;

4-[4-(4-Fluoro-phenyl)-6-(4-hydroxy-piperidin-1-yl)-pyrimidin-2-ylamino]-N,N-dimethyl-benzenesulfonamide;

4-[4-(4-Fluoro-phenyl)-6-(4-hydroxy-piperidin-1-yl)-pyrimidin-2-ylamino]-benzenesulfonamide;

4-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-N,N-dimethyl-benzenesulfonamide;

4-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-benzenesulfonamide;

4-[4-(4-Fluoro-phenyl)-6-(4-hydroxy-piperidin-1-yl)-pyrimidin-2-ylamino]-N-methyl-benzenesulfonamide;

4-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-benzamide;

4-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-N-methyl-benzamide;

N-Methyl-4-(4-morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-benzenesulfonamide;

N-Methyl-4-(4-morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-benzamide;

3-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-benzamide;

1-{3-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-phenyl}-ethanone;

3-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-N-methyl-benzamide;

N-Methyl-3-(4-morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-benzamide;

1-[4-(4-Morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-phenyl]-ethanone;

3-(4-Morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-benzamide;

1-[3-(4-Morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-phenyl]-ethanone;

3-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-benzenesulfonamide;

3-(4-Morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-benzenesulfonamide;

1-{4-[4-(4-Fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-ylamino]-phenyl}-ethanone;

1-{4-[4-(4-Fluoro-phenyl)-6-(4-hydroxy-piperidin-1-yl)-pyrimidin-2-ylamino]-phenyl}-ethanone;

1-[6-Phenyl-2-(4-trifluoromethoxy-phenylamino)-pyrimidin-4-yl]-piperidin-4-ol;

1-(2-Indol-1-yl-6-phenyl-pyrimidin-4-yl)-piperidin-4-ol;

4-(6-Phenyl-2-pyrrol-1-yl-pyrimidin-4-ylamino)-cyclohexanol;

1-(4-Benzo[1,3]dioxol-5-yl-6-phenyl-pyrimidin-2-yl)-piperidin-4-ol;

1-(4,6-Diphenyl-pyrimidin-2-yl)-piperidin-4-ol;

4-(2-Benzo[1,3]dioxol-5-yl-6-phenyl-pyrimidin-4-yl)-morpholine;

1-[2-(4-Fluoro-phenyl)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

1-[6-Phenyl-2-(4-trifluoromethoxy-phenyl)-pyrimidin-4-yl]-piperidin-4-ol;

1-(2-Benzo[1,3]dioxol-5-yl-6-phenyl-pyrimidin-4-yl)-piperidin-4-one;

1-[2-(3-Methanesulfonyl-phenyl)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

1-(6-Benzo[1,3]dioxol-5-yl-2-phenyl-pyrimidin-4-yl)-piperidin-4-ol;

1-[6-(3-Methanesulfonyl-phenyl)-2-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

4-(4-Fluoro-phenyl)-6-(4-methyl-piperazin-1-yl)-2-phenyl-pyrimidine;

4-(4-Methyl-piperazin-1-yl)-2,6-diphenyl-pyrimidine;

2-[2-(3-Chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-4-ylamino]-ethanol;

(3-Chloro-4-methoxy-phenyl)-(4-phenyl-6-piperazin-1-yl-pyrimidin-2-yl)-amine;

(6-Morpholin-4-yl-2-phenyl-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine;

1-[6-(3-Chloro-4-methoxy-phenylamino)-2-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

Benzo[1,3]dioxol-5-yl-(6-morpholin-4-yl-2-phenyl-pyrimidin-4-yl)-amine;

Benzo[1,3]dioxol-5-yl-[6-(4-methyl-piperazin-1-yl)-2-phenyl-pyrimidin-4-yl]-amine;

(2-Phenyl-6-piperazin-1-yl-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine;

1-{3-[4-Morpholin-4-yl-6-(4-trifluoromethoxy-phenylamino)-pyrimidin-2-yl]-phenyl}-ethanone;

(2,6-Diphenyl-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine;

4-(2,6-Diphenyl-pyrimidin-4-ylamino)-N-methyl-benzenesulfonamide;

4-(4-Ethyl-piperazin-1-yl)-2,6-diphenyl-pyrimidine;

4-(2,6-Diphenyl-pyrimidin-4-yl)-morpholine;

4-(4-Methyl-piperazin-1-yl)-2,6-diphenyl-pyrimidine;

1-[4-(3-Chloro-4-hydroxy-phenylamino)-6-phenyl-pyrimidin-2-yl]-pyrrolidine-2,5-dione;

Succinic acid mono-{1-[2-(3-chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-yl}ester;

4-[4-(3-Chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-2-ylamino]-cyclohexanol;

(3-Chloro-4-methoxy-phenyl)-[4-(4-ethyl-piperazin-1-yl)-6-phenyl-pyrimidin-2-yl]-amine;

(3-Chloro-4-methoxy-phenyl)-[4-(4-methyl-piperazin-1-yl)-6-phenyl-pyrimidin-2-yl]-amine;

[4-(1,1-Dioxo-1-lambda-6-thiomorpholin-4-yl)-6-phenyl-pyrimidin-2-yl]-(3-fluoro-4-methoxy-phenyl)-amine;

1-[2-(4-Methanesulfonyl-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

1-[4-(4-Methanesulfonyl-phenylamino)-6-phenyl-pyrimidin-2-yl]-piperidin-4-ol;

(2,6-Diphenyl-pyrimidin-4-yl)-(4-methanesulfonyl-phenyl)-amine;

1-[6-(4-Methanesulfonyl-phenylamino)-2-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

(4-Methanesulfonyl-phenyl)-(6-morpholin-4-yl-2-phenyl-pyrimidin-4-yl)-amine;

(4-Methanesulfonyl-phenyl)-[2-phenyl-6-(4-trifluoromethoxy-phenyl)-pyrimidin-4-yl]-amine;

Phthalic acid mono-[1-(2,6-diphenyl-pyrimidin-4-yl)-piperidin-4-yl]ester;

[4,6-Bis-(4-fluoro-phenyl)-pyrimidin-2-yl]-(4-trifluoromethoxy-phenyl)-amine;

[4-(3-Methanesulfonyl-phenyl)-6-morpholin-4-yl-pyrimidin-2-yl]-(4-trifluoromethoxy-phenyl)-amine;

[2-(4-Fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-4-yl]-(4-trifluoromethoxy-phenyl)-amine;

1-{4-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-phenyl}-ethanone;

1-[2-(4-methylsulfanyl-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

(2,6-diphenyl-pyrimidin-4-yl)-(4-methylsulfanyl-phenyl)-amine;

or any combination thereof;

or a salt, a prodrug, a diastereomeric mixture, an enantiomer, a tautomer, or a racemic mixture thereof.

15. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound selected from:

16. The composition as claimed in claim 15, further comprising:

optionally, a pharmaceutically acceptable auxiliary;

optionally, a pharmaceutically acceptable preservative;

optionally, a pharmaceutically acceptable excipient;

optionally, a pharmaceutically acceptable diluent; and

optionally, a pharmaceutically acceptable solvate.

17. The composition as claimed in claim 15, further comprising an agent selected from an immunosuppressive agent, a cytotoxic agent, an anti-inflammatory agent, an antirheumatic agent, a cardiovascular agent, or any combination thereof.

18. The composition as claimed in claim 15, wherein the composition is in the form of a tablet, a capsule, a cachet, a powder, a granule, a solution, a suspension, an emulsion, a bolus, a lozenge, a suppository, a pessary, a tampon, a cream, a gel, a paste, a foam, a spray, an aerosol, a microcapsule, a liposome, a transdermal patch, a pastille, a paste, or a mouthwash.

19. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound selected from:

20. The composition as claimed in claim 19, further comprising:

optionally, a pharmaceutically acceptable auxiliary;

optionally, a pharmaceutically acceptable preservative;

optionally, a pharmaceutically acceptable excipient;

optionally, a pharmaceutically acceptable diluent; and

optionally, a pharmaceutically acceptable solvate.

21. The composition as claimed in claim 19, further comprising an agent selected from an immunosuppressive agent, a cytotoxic agent, an anti-inflammatory agent, an antirheumatic agent, a cardiovascular agent, or any combination thereof.

22. The composition as claimed in claim 19, wherein the composition is in the form of a tablet, a capsule, a cachet, a powder, a granule, a solution, a suspension, an emulsion, a bolus, a lozenge, a suppository, a pessary, a tampon, a cream, a gel, a paste, a foam, a spray, an aerosol, a microcapsule, a liposome, a transdermal patch, a pastille, a paste, or a mouthwash.

23. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound selected from:

24. The composition as claimed in claim 23, further comprising:

optionally, a pharmaceutically acceptable auxiliary;

optionally, a pharmaceutically acceptable preservative;

optionally, a pharmaceutically acceptable excipient;

optionally, a pharmaceutically acceptable diluent; and

optionally, a pharmaceutically acceptable solvate.

25. The composition as claimed in claim 23, further comprising an agent selected from an immunosuppressive agent, a cytotoxic agent, an anti-inflammatory agent, an antirheumatic agent, a cardiovascular agent, or any combination thereof.

26. The composition as claimed in claim 23, wherein the composition is in the form of a tablet, a capsule, a cachet, a powder, a granule, a solution, a suspension, an emulsion, a bolus, a lozenge, a suppository, a pessary, a tampon, a cream, a gel, a paste, a foam, a spray, an aerosol, a microcapsule, a liposome, a transdermal patch, a pastille, a paste, or a mouthwash.

27. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound selected from:

28. The composition as claimed in claim 27, further comprising:

optionally, a pharmaceutically acceptable auxiliary;

optionally, a pharmaceutically acceptable preservative;

optionally, a pharmaceutically acceptable excipient;

optionally, a pharmaceutically acceptable diluent; and

optionally, a pharmaceutically acceptable solvate.

29. The composition as claimed in claim 27, further comprising an agent selected from an immunosuppressive agent, a cytotoxic agent, an anti-inflammatory agent, an antirheumatic agent, a cardiovascular agent, or any combination thereof.

30. The composition as claimed in claim 27, wherein the composition is in the form of a tablet, a capsule, a cachet, a powder, a granule, a solution, a suspension, an emulsion, a bolus, a lozenge, a suppository, a pessary, a tampon, a cream, a gel, a paste, a foam, a spray, an aerosol, a microcapsule, a liposome, a transdermal patch, a pastille, a paste, or a mouthwash.

31. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound selected from:

N⁴-(3-Chloro-4-methoxy-phenyl)-6-(4-methoxy-phenyl)-pyrimidine-2,4-diamine;

N⁴-(3-Chloro-4-methoxy-phenyl)-6-phenyl-pyrimidine-2,4-diamine;

N⁴-(3-Chloro-4-methoxy-phenyl)-6-(4-fluoro-phenyl)-pyrimidine-2,4-diamine;

N⁴-(3-Chloro-4-methoxy-phenyl)-6-(4-ethoxy-phenyl)-pyrimidine-2,4-diamine;

N⁴-(3-Chloro-4-methoxy-phenyl)-6-p-tolyl-pyrimidine-2,4-diamine;

N⁴-(3-Chloro-4-methoxy-phenyl)-6-(4-methylsulfanyl-phenyl)-pyrimidine-2,4-diamine;

N⁴-(3-Fluoro-4-methoxy-phenyl)-6-(4-methoxy-phenyl)-pyrimidine-2,4-diamine;

4-[2-Amino-6-(4-methoxy-phenyl)-pyrimidin-4-ylamino]-2-chloro-phenol;

N⁴-Benzo[1,3]dioxo-5yl-6-phenyl-pyrimidin-2,4-diamine;

N⁴-(4-Chloro-3-methoxy-phenyl)-6-phenyl-pyrimidine-2,4-diamine;

4-(2-Amino-6-phenyl-pyrimidin-4-ylamino)-2-chloro-phenol;

2-(2-Amino-6-phenyl-pyrimidin-4-ylamino)-benzoic acid ethyl ester;

N⁴-(3-Chloro-4-methoxy-phenyl)-6-methyl-pyrimidine-2,4-diamine;

5-[2-Amino-6-(4-methylsulfanylphenyl)pyrimidin-4-ylamino]-1-methyl-3-propyl-1H-pyrazole-4-carboxylic acid amide;

6-Chloro-N²-(3-chloro-4-methoxy-phenyl)-N⁴-cycloheptyl-pyrimidine-2,4-diamine;

1-[2-(3-Chloro-4-methoxy-phenylamino)-6-cycloheptylamino-pyrimidin-4-yl]-piperidin-4-ol;

N²,N⁴-Bis-(3-chloro-4-methoxy-phenyl)-6-phenyl-pyrimidine-2,4-diamine;

N-[4-(3-Chloro-4-methoxy-phenylamino)-6-(4-ethoxy-phenyl)-pyrimidin-2-yl]-acetamide;

N-[4-(3-Chloro-4-methoxy-phenylamino)-6-(4-methoxy-phenyl)-pyrimidin-2-yl]-acetamide;

N-[4-(3-Chloro-4-methoxy-phenylamino)-6-(4-methoxy-phenyl)-pyrimidin-2-yl]-propionamide;

[4-(3-Chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-2-ylamino]-acetic acid ethyl ester;

N-[4-(3-Chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-2-yl]-2,2,2-trifluoro-acetamide;

2,2,2-Trifluoro-N-(4-hydroxy-6-phenyl-pyrimidin-2-yl)-acetamide;

4-(4-Fluoro-phenylsulfanyl)-6-phenyl-pyrimidin-2-ylamine;

(3-Chloro-4-methoxy-phenyl)-(2-ethylsulfanyl-6-phenyl-pyrimidin-4-yl)-amine;

4-(3-Chloro-4-hydroxy-phenylamino)-6-phenyl-pyrimidin-2-ol;

N²-(3-Chloro-4-methoxy-phenyl)-N⁴-methyl-6-phenyl-pyrimidine-2,4-diamine;

N²-(3-Chloro-4-methoxy-phenyl)-N⁴-isopropyl-6-phenyl-pyrimidine-2,4-diamine;

N²-(3-Chloro-4-methoxy-phenyl)-N⁴-cycloheptyl-6-phenyl-pyrimidine-2,4-diamine;

N⁴-Benzyl-N²-(3-chloro-4-methoxy-phenyl)-6-phenyl-pyrimidine-2,4-diamine;

2-(3-Chloro-4-methoxy-phenylamino)-6-(4-methoxy-phenyl)-pyrimidin-4-ol;

2-(3-Chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-4-ol;

(3-Chloro-4-methoxy-phenyl)-[4-ethoxy-6-(4-methoxy-phenyl)-pyrimidin-2-yl]-amine;

(3-Chloro-4-methoxy-phenyl)-[4-isopropoxy-6-(4-methoxy-phenyl)-pyrimidin-2-yl]-amine;

[4-Benzyloxy-6-(4-methoxy-phenyl)-pyrimidin-2-yl]-(3-chloro-4-methoxy-phenyl)-amine;

(3-Chloro-4-methoxy-phenyl)-[4-(4-methoxy-phenyl)-6-(4-methyl-benzyloxy)-pyrimidin-2-yl]-amine;

[2-(3-Chloro-4-methoxy-phenylamino)-6-(4-methoxy-phenyl)-pyrimidin-4-yloxy]-acetic acid ethyl ester;

[2-(3-Chloro-4-methoxy-phenylamino)-6-(4-methoxy-phenyl)-pyrimidin-4-yloxy]-acetic acid;

4-(3-Chloro-4-methoxy-phenyl)-6-phenyl-pyrimidin-2-ylamine;

1-[4-(3-Chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-2-yl]-piperidin-4-ol;

1-[4-(3-Fluoro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-2-yl]-piperidin-4-ol;

1-[4-(Methyl-phenyl-amino)-6-phenyl-pyrimidin-2-yl]-piperidin-4-ol;

1-[4-Phenyl-6-(3-trifluoromethyl-phenylamino)-pyrimidin-2-yl]-piperidin-4-ol;

1-[4-(4-Chloro-3-trifluoromethyl-phenylamino)-6-phenyl-pyrimidin-2-yl]-piperidin-4-ol;

1-[4-(Benzo[1,3]dioxol-5-ylamino)-6-phenyl-pyrimidin-2-yl]-piperidin-4-ol;

1-[4-Phenyl-6-(4-trifluoromethyl-phenylamino)-pyrimidin-2-yl]-piperidin-4-ol;

(2-Morpholin-4-yl-6-phenyl-pyrimidin-4-yl)-(3-rifluoromethyl-phenyl)-amine;

1-[4-Phenyl-6-(4-trifluoromethoxy-phenylamino)-pyrimidin-2-yl]-piperidin-4-ol;

1-[2-(3-Chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

(4-Morpholin-4-yl-6-phenyl-pyrimidin-2-yl)-(4-trifluoromethoxy-phenyl)-amine;

4-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-N-methyl-benzenesulfonamide;

1-{4-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-phenyl}-ethanone hydro chloride;

1-[2-(3-Chloro-4-hydroxy-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

1-[2-(3-Fluoro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

1-(6-Phenyl-2-phenylamino-pyrimidin-4-yl)-piperidin-4-ol;

(3-Chloro-4-methoxy-phenyl)-(4-phenyl-6-thiomorpholin-4-yl-pyrimidin-2-yl)-amine;

Benzo[1,3]dioxol-5-yl-(4-phenyl-6-thiomorpholin-4-yl-pyrimidin-2-yl)-amine;

(3-Fluoro-4-methoxy-phenyl)-(4-phenyl-6-thiomorpholin-4-yl-pyrimidin-2-yl)-amine;

2-Chloro-4-(4-phenyl-6-thiomorpholin-4-yl-pyrimidin-2-ylamino)-phenol;

(3-Chloro-4-methoxy-phenyl)-(4-morpholin-4-yl-6-phenyl-pyrimidin-2-yl)-amine;

Benzo[1,3]dioxol-5-yl-(4-morpholin-4-yl-6-phenyl-pyrimidin-2-yl)-amine;

(3-Fluoro-4-methoxy-phenyl)-(4-morpholin-4-yl-6-phenyl-pyrimidin-2-yl)-amine;

2-Chloro-4-(4-morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-phenol;

1-[6-Phenyl-2-(3-trifluoromethyl-phenylamino)-pyrimidin-4-yl]-piperidin-4-ol;

Benzo[1,3]dioxol-5-yl-[4-(4-fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-yl]-amine;

1-[2-(Benzo[1,3]dioxol-5-ylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

[4-(4-Fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine;

(4-Fluoro-phenyl)-[4-(4-fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-yl]-amine;

1-[2-(4-Chloro-3-trifluoromethyl-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

(4-Morpholin-4-yl-6-phenyl-pyrimidin-2-yl)-(3-trifluoromethyl-phenyl)-amine;

N-{4-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-phenyl}-methanesulfonamide;

N-[4-(4-Morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-phenyl]-methanesulfonamide hydrochloride;

4-[4-(4-Fluoro-phenyl)-6-(4-hydroxy-piperidin-1-yl)-pyrimidin-2-ylamino]-N,N-dimethyl-benzenesulfonamide;

4-[4-(4-Fluoro-phenyl)-6-(4-hydroxy-piperidin-1-yl)-pyrimidin-2-ylamino]-benzenesulfonamide;

4-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-N,N-dimethyl-benzenesulfonamide;

4-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-benzenesulfonamide;

4-[4-(4-Fluoro-phenyl)-6-(4-hydroxy-piperidin-1-yl)-pyrimidin-2-ylamino]-N-methyl-benzenesulfonamide;

4-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-benzamide;

4-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-N-methyl-benzamide;

N-Methyl-4-(4-morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-benzenesulfonamide;

N-Methyl-4-(4-morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-benzamide;

3-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-benzamide;

1-{3-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-phenyl}-ethanone;

3-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-N-methyl-benzamide;

N-Methyl-3-(4-morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-benzamide;

1-[4-(4-Morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-phenyl]-ethanone;

3-(4-Morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-benzamide;

1-[3-(4-Morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-phenyl]-ethanone;

3-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-benzenesulfonamide;

3-(4-Morpholin-4-yl-6-phenyl-pyrimidin-2-ylamino)-benzenesulfonamide;

1-{4-[4-(4-Fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-2-ylamino]-phenyl}-ethanone;

1-{4-[4-(4-Fluoro-phenyl)-6-(4-hydroxy-piperidin-1-yl)-pyrimidin-2-ylamino]-phenyl}-ethanone;

1-[6-Phenyl-2-(4-trifluoromethoxy-phenylamino)-pyrimidin-4-yl]-piperidin-4-ol;

1-(2-Indol-1-yl-6-phenyl-pyrimidin-4-yl)-piperidin-4-ol;

4-(6-Phenyl-2-pyrrol-1-yl-pyrimidin-4-ylamino)-cyclohexanol;

1-(4-Benzo[1,3]dioxol-5-yl-6-phenyl-pyrimidin-2-yl)-piperidin-4-ol;

1-(4,6-Diphenyl-pyrimidin-2-yl)-piperidin-4-ol;

1-(2,6-Diphenyl-pyrimidin-4-yl)-piperidin-4-ol;

1-(2-Benzo[1,3]dioxol-5-yl-6-phenyl-pyrimidin-4-yl)-piperidin-4-ol;

4-(2-Benzo[1,3]dioxol-5-yl-6-phenyl-pyrimidin-4-yl)-morpholine;

1-[2-(4-Fluoro-phenyl)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

1-[6-Phenyl-2-(4-trifluoromethoxy-phenyl)-pyrimidin-4-yl]-piperidin-4-ol;

1-(2-Benzo[1,3]dioxol-5-yl-6-phenyl-pyrimidin-4-yl)-piperidin-4-one;

1-[2-(3-Methanesulfonyl-phenyl)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

1-(6-Benzo[1,3]dioxol-5-yl-2-phenyl-pyrimidin-4-yl)-piperidin-4-ol;

1-[6-(3-Methanesulfonyl-phenyl)-2-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

4-(4-Fluoro-phenyl)-6-(4-methyl-piperazin-1-yl)-2-phenyl-pyrimidine;

4-(4-Methyl-piperazin-1-yl)-2,6-diphenyl-pyrimidine;

4,6-Bis-(4-fluoro-phenyl)-pyrimidin-2-ylamine;

(3-Chloro-4-methoxy-phenyl)-(4-phenyl-6-phenylethynyl-pyrimidin-2-yl)-amine;

2-[2-(3-Chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-4-ylamino]-ethanol;

4-Phenyl-6-phenylethynyl-pyrimidin-2-ylamine;

(3-Chloro-4-methoxy-phenyl)-(4-phenyl-6-piperazin-1-yl-pyrimidin-2-yl)-amine;

(6-Morpholin-4-yl-2-phenyl-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine;

1-[6-(3-Chloro-4-methoxy-phenylamino)-2-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

Benzo[1,3]dioxol-5-yl-(6-morpholin-4-yl-2-phenyl-pyrimidin-4-yl)-amine;

Benzo[1,3]dioxol-5-yl-[6-(4-methyl-piperazin-1-yl)-2-phenyl-pyrimidin-4-yl]-amine;

(2-Phenyl-6-piperazin-1-yl-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine;

(6-Phenyl-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine;

1-{3-[2-Morpholin-4-yl-6-(4-trifluoromethoxy-phenylamino)-pyrimidin-4-yl]-phenyl}-ethanone;

1-{3-[4-Morpholin-4-yl-6-(4-trifluoromethoxy-phenylamino)-pyrimidin-2-yl]-phenyl}-ethanone;

(2,6-Diphenyl-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine;

4-(2,6-Diphenyl-pyrimidin-4-ylamino)-N-methyl-benzenesulfonamide;

4-(4-Ethyl-piperazin-1-yl)-2,6-diphenyl-pyrimidine;

4-(2,6-Diphenyl-pyrimidin-4-yl)-morpholine;

4-(4-Methyl-piperazin-1-yl)-2,6-diphenyl-pyrimidine;

N⁴-(3-Chloro-4-methoxy-phenyl)-6-(phenyl-pyrimidin-2-yl]-pyrrolidine-diamine;

1-[4-(3-Chloro-4-hydroxy-phenylamino)-6-phenyl-pyrimidin-2-yl]-pyrrolidine-2,5-dione;

2-(2-Amino-6-phenyl-pyrimidin-4-ylamino)-benzoic acid;

Succinic acid mono-{1-[2-(3-chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-yl}ester;

[4-(3-Chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-2-ylsulfanyl]-acetic acid ethyl ester;

4-(3-Chloro-4-methoxy-phenyl)-6-pyridin-3-yl-pyrimidin-2-ylamine;

4-[2-(3-Chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-4-ylamino]-cyclohexanol;

4-[4-(3-Chloro-4-methoxy-phenylamino)-6-phenyl-pyrimidin-2-ylamino]-cyclohexanol;

(3-Chloro-4-methoxy-phenyl)-[4-(4-ethyl-piperazin-1-yl)-6-phenyl-pyrimidin-2-yl]-amine;

(3-Chloro-4-methoxy-phenyl)-[4-(4-methyl-piperazin-1-yl)-6-phenyl-pyrimidin-2-yl]-amine;

[4-(1,1-Dioxo-1-lambda-6-thiomorpholin-4-yl)-6-phenyl-pyrimidin-2-yl]-(3-fluoro-4-methoxy-phenyl)-amine;

1-[2-(4-Methanesulfonyl-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

1-[4-(4-Methanesulfonyl-phenylamino)-6-phenyl-pyrimidin-2-yl]-piperidin-4-ol;

(2,6-Diphenyl-pyrimidin-4-yl)-(4-methanesulfonyl-phenyl)-amine;

1-[6-(4-Methanesulfonyl-phenylamino)-2-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

(4-Methanesulfonyl-phenyl)-(6-morpholin-4-yl-2-phenyl-pyrimidin-4-yl)-amine;

(4-Methanesulfonyl-phenyl)-[2-phenyl-6-(4-trifluoromethoxy-phenyl)-pyrimidin-4-yl]-amine;

Phthalic acid mono-[1-(2,6-diphenyl-pyrimidin-4-yl)-piperidin-4-yl] ester;

[4,6-Bis-(4-fluoro-phenyl)-pyrimidin-2-yl]-(4-trifluoromethoxy-phenyl)-amine;

[4-(3-Methanesulfonyl-phenyl)-6-morpholin-4-yl-pyrimidin-2-yl]-(4-trifluoromethoxy-phenyl)-amine;

[2-(4-Fluoro-phenyl)-6-morpholin-4-yl-pyrimidin-4-yl]-(4-trifluoromethoxy-phenyl)-amine;

1-{4-[4-(4-Hydroxy-piperidin-1-yl)-6-phenyl-pyrimidin-2-ylamino]-phenyl}-ethanone;

2-amino-6-(4-methoxy-phenyl)-pyrimidin-4-ol;

2-Amino-6-phenyl-pyrimidin-4-ol;

2-Amino-6-(4-fluoro-phenyl)-pyrimidin-4-ol;

2-Amino-6-(4-ethoxy-phenyl)-pyrimidin-4-ol;

2-Amino-6-p-tolyl-pyrimidin-4-ol;

2-Amino-6-(4-methylsulfanyl-phenyl)-pyrimidin-4-ol;

4-chloro-6-(4-methoxy-phenyl)-pyrimidin-2-ylamine

4-Chloro-6-phenyl-pyrimidin-2-ylamine;

4-Chloro-6-(4-fluoro-phenyl)-pyrimidin-2-ylamine;

4-chloro-6-(4-ethoxy-phenyl)-pyrimidin-2-ylamine;

4-Chloro-6-p-tolyl-pyrimidin-2-ylamine;

4-chloro-6-(4-methylsulfanylphenyl)pyrimidin-2-ylamine;

(3-chloro-4-methoxy-phenyl)-(4,6-dichloro-pyrimidin-2-yl)-amine;

2,4-Dichloro-6-(4-methoxy-phenyl)-pyrimidine;

2,4-Dichloro-6-phenyl-pyrimidine;

4,6-dichloro-2-phenyl-pyrimidine;

2,4-Dichloro-6-(4-ethoxy-phenyl)-pyrimidine;

2,4-Dichloro-6-p-tolyl-pyrimidine;

2,4-Dichloro-6-(4-methylsulfanyl-phenyl)-pyrimidine;

N-[4-chloro-6-(4-ethoxy-phenyl)-pyrimidin-2-yl]-formamide;

N-[4-Chloro-6-(4-methoxy-phenyl)-pyrimidin-2-yl]-acetamide;

N-[4-Chloro-6-(4-methoxy-phenyl)-pyrimidin-2-yl]-propionamide;

(4-Chloro-6-phenyl-pyrimidin-2-ylamino)-acetic acid ethyl ester;

2-mercapto-6-phenyl-pyrimidin-4-ol;

2-ethylsulfanyl-6-arylpyrimidin-4-ol;

4-chloro-2-ethylsulfanyl-6-phenylpyrimidine;

(2-ethylsulfanyl-6-phenylpyrimidin-4-yl) methylamine;

(2-Ethylsulfanyl-6-phenyl-pyrimidin-4-yl)-isopropyl-amine;

Cycloheptyl-(2-ethylsulfanyl-6-phenyl-pyrimidin-4-yl)-amine;

Benzyl-(2-ethylsulfanyl-6-phenyl-pyrimidin-4-yl)-amine;

4-methylamino-6-phenylpyrimidin-2-ol;

4-Isopropylamino-6-phenyl-pyrimidin-2-ol;

4-Cycloheptylamino-6-phenyl-pyrimidin-2-ol;

4-Benzylamino-6-phenyl-pyrimidin-2-ol;

(2-chloro-6-phenylpyrimidin-4-yl) alkylamine;

(2-Chloro-6-phenyl-pyrimidin-4-yl)-isopropyl-amine;

(2-Chloro-6-phenyl-pyrimidin-4-yl)-cycloheptyl-amine;

Benzyl-(2-chloro-6-phenyl-pyrimidin-4-yl)-amine;

2-ethylsulfanyl-6-(4-methoxy-phenyl)-pyrimidin-4-ol;

6-phenyl-pyrimidine-2,4-diol;

2-phenyl-pyrimidine-4,6-diol;

1-(4-chloro-6-phenyl-pyrimidin-2-yl)-piperidin-4-ol;

4-(4-Chloro-6-phenyl-pyrimidin-2-yl)-morpholine;

4-(4-Chloro-6-phenyl-pyrimidin-2-yl)-thiomorpholine;

1-(2-chloro-6-phenyl-pyrimidin-4-yl)-piperidin-4-ol;

4-(2-chloro-6-phenyl-pyrimidin-4-yl)-morpholine;

4-(2-chloro-6-phenyl-pyrimidin-4-yl)-thiomorpholine;

1-(2-Chloro-6-phenyl-pyrimidin-4-yl)-piperidin-4-one;

2-Chloro-4-(4-methyl-piperazin-1-yl)-6-phenyl-pyrimidine;

6-(4-Fluoro-phenyl)-pyrimidine-2,4-diol;

2,4-Dichloro-6-(4-fluoro-phenyl)-pyrimidine;

1-[4-Chloro-6-(4-fluoro-phenyl)-pyrimidin-2-yl]-piperidin-4-ol;

4-[4-Chloro-6-(4-fluoro-phenyl)-pyrimidin-2-yl]-morpholine;

1-[2-Chloro-6-(4-fluoro-phenyl)-pyrimidin-4-yl]-piperidin-4-ol;

4-[2-Chloro-6-(4-fluoro-phenyl)-pyrimidin-4-yl]-morpholine;

(3-chloro-4-methoxy-phenyl)-(4-chloro-6-phenyl-pyrimidin-2-yl)-amine;

(6-chloro-2-phenyl-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine;

(3-Chloro-4-methoxy-phenyl)-(6-chloro-2-phenyl-pyrimidin-4-yl)-amine;

Benzo[1,3]dioxol-5-yl-(6-chloro-2-phenyl-pyrimidin-4-yl)-amine;

(6-Chloro-2-phenyl-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine;

6-phenyl-pyrimidin-4-ol;

4-chloro-6-phenyl-pyrimidine;

(2,6-dichloro-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine;

(6-chloro-2-morpholin-4-yl-pyrimidin-4-yl)-(4-trifluoromethoxy-phenyl)-amine;

1-{3-[4-chloro-6-(4-trifluoromethoxy-phenylamino)-pyrimidin-2-yl]-phenyl}-ethanone;

2,6-Diphenyl-pyrimidin-4-ol;

4-Chloro-2,6-diphenyl-pyrimidine;

4-hydroxy-6-phenyl-pyrimidin-2-ylsulfanyl)-acetic acid ethyl ester;

4-chloro-6-phenyl-pyrimidin-2-ylsulfanyl)-acetic acid ethyl ester;

4-(2-chloro-6-phenyl-pyrimidin-4-ylamino)-cyclohexanol;

4-(4-chloro-6-phenyl-pyrimidin-2-ylamino)-cyclohexanol;

1-[2-(4-methylsulfanyl-phenylamino)-6-phenyl-pyrimidin-4-yl]-piperidin-4-ol;

1-[4-(4-methylsulfanyl-phenylamino)-6-phenyl-pyrimidin-2-yl]-piperidin-4-ol;

(2,6-diphenyl-pyrimidin-4-yl)-(4-methylsulfanyl-phenyl)-amine;

(6-chloro-2-phenyl-pyrimidin-4-yl)-(4-methylsulfanyl-phenyl)-amine;

(6-chloro-2-phenyl-pyrimidin-4-yl)-(4-methanesulfonyl-phenyl)-amine;

(4,6-dichloro-pyrimidin-2-yl)-(4-trifluoromethoxy-phenyl)-amine;

[4-chloro-6-(3-methanesulfonyl-phenyl)-pyrimidin-2-yl]-(4-trifluoromethoxy-phenyl)-amine;

2-(4-fluoro-phenyl)-pyrimidine-4,6-diol;

4,6-dichloro-2-(4-fluoro-phenyl)-pyrimidine;

[6-chloro-2-(4-fluoro-phenyl)-pyrimidin-4-yl]-(4-trifluoromethoxy-phenyl)-amine;

or any combination thereof;

or a pharmaceutically acceptable salt, a prodrug, a diastereomeric mixture, an enantiomer, a tautomer, or a racemic mixture thereof.

32. The composition as claimed in claim 31, further comprising:

optionally, a pharmaceutically acceptable auxiliary;

optionally, a pharmaceutically acceptable preservative;

optionally, a pharmaceutically acceptable excipient;

optionally, a pharmaceutically acceptable diluent; and

optionally, a pharmaceutically acceptable solvate.

33. The composition as claimed in claim 31, further comprising an agent selected from an immunosuppressive agent, a cytotoxic agent, an anti-inflammatory agent, an antirheumatic agent, a cardiovascular agent, or any combination thereof.

34. The composition as claimed in claim 31, wherein the composition is in the form of a tablet, a capsule, a cachet, a powder, a granule, a solution, a suspension, an emulsion, a bolus, a lozenge, a suppository, a pessary, a tampon, a cream, a gel, a paste, a foam, a spray, an aerosol, a microcapsule, a liposome, a transdermal patch, a pastille, a paste, or a mouthwash.