Methods and compositions for enhancing degradation of nuclear receptor transcription factors and uses thereof
First Claim
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1. A method of inhibiting a nuclear receptor activation pathway, comprising:
- a) providing a cell comprising a nuclear receptor activation pathway; and
b) introducing a compound capable of enhancing degradation of a nuclear receptor in said nuclear receptor activation pathway.
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Abstract
The present invention includes methods, compositions, cosmetics and pharmaceutical compositions for enhancing the degradation of a nuclear receptor (NR) or a STAT transcription factor protein. The methods, compositions, cosmetics and pharmaceuticals may be used to prevent or treat disorders or medical conditions that are at least in part affected by a nuclear receptor activation pathway or STAT activation pathway.
62 Citations
30 Claims
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1. A method of inhibiting a nuclear receptor activation pathway, comprising:
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a) providing a cell comprising a nuclear receptor activation pathway; and
b) introducing a compound capable of enhancing degradation of a nuclear receptor in said nuclear receptor activation pathway. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of inhibiting a STAT activation pathway comprising:
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a) providing a cell comprising a STAT activation pathway; and
b) introducing a compound capable of enhancing degradation of a STAT transcription factor protein in said nuclear receptor activation pathway. - View Dependent Claims (12, 13)
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14. A cosmetic composition comprising:
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a) a compound capable of inducing degradation of a nuclear receptor; and
a) a cosmetically acceptable carrier. - View Dependent Claims (17, 18)
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- 15. The cosmetic composition according to claim 15, wherein said compound is a curcumin analogue or curcumin derivative.
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19. A cosmetic composition comprising:
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a) a compound capable of inducing degradation of a STAT transcription factor protein; and
b) a cosmetically acceptable carrier. - View Dependent Claims (20)
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21. A pharmaceutical composition comprising:
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a) a compound or a pharmaceutically acceptable salt thereof capable of enhancing degradation of a nuclear receptor; and
b) a pharmaceutically acceptable carrier. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification