High affinity TGFbeta nucleic acid ligands and inhibitors
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Abstract
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGFβ2. Included in the invention are specific RNA ligands to TGFβ2 identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of TGFβ2 with its receptor.
57 Citations
14 Claims
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1-8. -8. (canceled)
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9. A complex comprised of a TGFβ
- 2 nucleic acid ligand and a non-immunogenic, high molecular weight compound or lipophilic compound.
- View Dependent Claims (10, 11, 12, 13, 14)
Specification